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    STE7 mitogen-activated protein kinase kinase STE7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851396, updated on 17-May-2024

    Summary

    Gene symbol
    STE7
    Gene description
    mitogen-activated protein kinase kinase STE7
    Primary source
    FungiDB:YDL159W
    Locus tag
    YDL159W
    See related
    SGD:S000002318; AllianceGenome:SGD:S000002318; VEuPathDB:YDL159W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables MAP kinase kinase activity. Involved in several processes, including MAPK cascade; invasive growth in response to glucose limitation; and pseudohyphal growth. Located in cytoplasm and mating projection tip. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; cardiofaciocutaneous syndrome 4; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1) and MAP2K2 (mitogen-activated protein kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See STE7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (172481..174028)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene DExD/H-box ATP-dependent RNA helicase DHH1 Neighboring gene uncharacterized protein Neighboring gene Dmo2p Neighboring gene Cmr1p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MAP kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase STE7
    NP_010122.1
    • Signal transducing MAP kinase kinase; involved in pheromone response where it phosphorylates Fus3p; involved in the pseudohyphal/invasive growth pathway where it phosphorylates of Kss1p; phosphorylated by Ste11p; degraded by ubiquitin pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      172481..174028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180219.1NP_010122.1  TPA: mitogen-activated protein kinase kinase STE7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010122.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRJ2, P06784
      UniProtKB/TrEMBL
      A0A6A5Q0Q1, A6ZXH1, B3LH45, G2WC05, N1P953
      Conserved Domains (1) summary
      cd06620
      Location:185482
      PKc_Byr1_like; Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases