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    PTP1 tyrosine protein phosphatase PTP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851368, updated on 17-May-2024

    Summary

    Gene symbol
    PTP1
    Gene description
    tyrosine protein phosphatase PTP1
    Primary source
    FungiDB:YDL230W
    Locus tag
    YDL230W
    See related
    SGD:S000002389; AllianceGenome:SGD:S000002389; VEuPathDB:YDL230W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein tyrosine phosphatase activity. Involved in invasive growth in response to glucose limitation; protein dephosphorylation; and pseudohyphal growth. Located in mitochondrion. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); hepatitis C; multiple sclerosis; and severe combined immunodeficiency (multiple). Orthologous to several human genes including PTPRS (protein tyrosine phosphatase receptor type S). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See PTP1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (42700..43707)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene olichyl-diphosphooligosaccharide--protein glycotransferase OST4 Neighboring gene Bre4p Neighboring gene Hsp70 family ATPase SSB1 Neighboring gene Hop

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    tyrosine protein phosphatase PTP1
    NP_010051.1
    • Phosphotyrosine-specific protein phosphatase; dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      42700..43707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180290.1NP_010051.1  TPA: tyrosine protein phosphatase PTP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010051.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRC6, P25044
      UniProtKB/TrEMBL
      A0A8H8UM74, A6ZXA4, B5VF49, C7GJP9, C8Z6N9, G2WBT9, N1P606
      Conserved Domains (1) summary
      COG5599
      Location:1335
      COG5599; Protein tyrosine phosphatase [Signal transduction mechanisms]