U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CDC24 Rho family guanine nucleotide exchange factor CDC24 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851190, updated on 9-Jun-2024

    Summary

    Gene symbol
    CDC24
    Gene description
    Rho family guanine nucleotide exchange factor CDC24
    Primary source
    FungiDB:YAL041W
    Locus tag
    YAL041W
    See related
    SGD:S000000039; AllianceGenome:SGD:S000000039; VEuPathDB:YAL041W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CLS4
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including cellular bud site selection; chemotropism; and regulation of exit from mitosis. Acts upstream of or within pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in several cellular components, including cellular bud neck; cellular bud tip; and mating projection tip. Part of Cdc24p-Far1p-Gbetagamma complex and incipient cellular bud site. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 8. Orthologous to several human genes including ARHGEF9 (Cdc42 guanine nucleotide exchange factor 9); ARHGEF4 (Rho guanine nucleotide exchange factor 4); and PLEKHG1 (pleckstrin homology and RhoGEF domain containing G1). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CDC24 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (62840..65404)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene RNA-processing protein PTA1 Neighboring gene Erv46p Neighboring gene cyclin CLN3 Neighboring gene holocytochrome c synthase CYC3

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Cdc24p-Far1p-Gbetagamma complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Cdc24p-Far1p-Gbetagamma complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in division septum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mating projection tip IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Rho family guanine nucleotide exchange factor CDC24
    NP_009359.1
    • Guanine nucleotide exchange factor (GEF) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress; thermosensitivity of the cdc24-4 mutant in the presence of sorbitol is functionally complemented by human CDC42

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      62840..65404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178186.1NP_009359.1  TPA: Rho family guanine nucleotide exchange factor CDC24 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009359.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPH5, P11433
      UniProtKB/TrEMBL
      A0A8H4BZY6, B3LUX7, C7GPJ6, C8Z3E8, G2W8I9, N1P7H4
      Conserved Domains (4) summary
      smart00325
      Location:282453
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      smart00666
      Location:779853
      PB1; PB1 domain
      cd13246
      Location:455667
      PH_Scd1; Shape and Conjugation Deficiency 1 Pleckstrin homology (PH) domain
      pfam06395
      Location:156242
      CDC24; CDC24 Calponin