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    CDC42BPA CDC42 binding protein kinase alpha [ Homo sapiens (human) ]

    Gene ID: 8476, updated on 8-Dec-2018

    Summary

    Official Symbol
    CDC42BPAprovided by HGNC
    Official Full Name
    CDC42 binding protein kinase alphaprovided by HGNC
    Primary source
    HGNC:HGNC:1737
    See related
    Ensembl:ENSG00000143776 MIM:603412
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRCK; MRCKA; PK428
    Summary
    The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]
    Expression
    Ubiquitous expression in testis (RPKM 11.8), kidney (RPKM 9.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See CDC42BPA in Genome Data Viewer
    Location:
    1q42.13
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (226989865..227318502, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (227177566..227506193, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985354 Neighboring gene glucose-dependent insulinotropic receptor-like Neighboring gene coenzyme Q8A Neighboring gene cathepsin B pseudogene Neighboring gene ubiquitin like modifier activating enzyme 5 pseudogene Neighboring gene phosphatidylinositol 4-kinase type 2 beta pseudogene Neighboring gene long intergenic non-protein coding RNA 1641 Neighboring gene nuclear casein kinase and cyclin dependent kinase substrate 1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ23347, KIAA0451, DKFZp686L1738, DKFZp686P1738

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton reorganization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actomyosin structure organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    actomyosin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell leading edge ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 
    lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase MRCK alpha
    Names
    CDC42 binding protein kinase alpha (DMPK-like)
    CDC42 binding protein kinase beta
    myotonic dystrophy kinase-related CDC42-binding protein kinase alpha
    myotonic dystrophy protein kinase-like alpha
    ser-thr protein kinase PK428
    ser-thr protein kinase related to the myotonic dystrophy protein kinase
    NP_003598.2
    NP_055641.3
    XP_005273374.1
    XP_005273375.1
    XP_005273377.1
    XP_005273378.1
    XP_005273379.1
    XP_005273381.1
    XP_006711897.1
    XP_006711898.1
    XP_011542608.1
    XP_011542609.1
    XP_011542610.1
    XP_011542611.1
    XP_016858067.1
    XP_016858068.1
    XP_016858069.1
    XP_016858070.1
    XP_016858071.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001366010.1NP_001352939.1  serine/threonine-protein kinase MRCK alpha isoform D

      Status: REVIEWED

      Source sequence(s)
      AB208968, AL353689, AL627308, BC136333
      Conserved Domains (7) summary
      smart00285
      Location:15301564
      PBD; P21-Rho-binding domain
      COG0419
      Location:442979
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00029
      Location:9721021
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:10311165
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:11911455
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    2. NM_001366011.1NP_001352940.1  serine/threonine-protein kinase MRCK alpha isoform E

      Status: REVIEWED

      Source sequence(s)
      AL353689, AL627308, BC136333
      Conserved Domains (7) summary
      smart00285
      Location:15381572
      PBD; P21-Rho-binding domain
      COG0419
      Location:442944
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00029
      Location:9801029
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:10391173
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:11991463
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    3. NM_001366019.1NP_001352948.1  serine/threonine-protein kinase MRCK alpha isoform C

      Status: REVIEWED

      Source sequence(s)
      AL353689, AL451047, AL627308
      Conserved Domains (6) summary
      COG0419
      Location:432941
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00029
      Location:10131062
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:10721206
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12321496
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    4. NM_003607.3NP_003598.2  serine/threonine-protein kinase MRCK alpha isoform B

      See identical proteins and their annotated locations for NP_003598.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) encodes the longer isoform (B).
      Source sequence(s)
      AJ518975, AL353689, AL627308, BC050335, BF765241, BQ232716, BX648219
      Consensus CDS
      CCDS1558.1
      UniProtKB/Swiss-Prot
      Q5VT25
      Related
      ENSP00000355731.3, ENST00000366769.7
      Conserved Domains (8) summary
      pfam08826
      Location:881941
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:77343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:481791
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00029
      Location:10001049
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:10591193
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12191483
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    5. NM_014826.4NP_055641.3  serine/threonine-protein kinase MRCK alpha isoform A

      See identical proteins and their annotated locations for NP_055641.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A) lacks a coding segment compared to variant B, resulting in an isoform (A) that lacks an internal region, as compared to isoform B.
      Source sequence(s)
      AJ518976, AL353689, AL627308, BC050335, BF765241, BQ232716, BX648219
      Consensus CDS
      CCDS1559.1
      UniProtKB/Swiss-Prot
      Q5VT25
      Related
      ENSP00000355729.3, ENST00000366767.7
      Conserved Domains (7) summary
      pfam08826
      Location:800860
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:77343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:919968
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:9781112
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:11381402
      CNH; CNH domain
      pfam15619
      Location:447614
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      226989865..227318502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002580.2XP_016858069.1  serine/threonine-protein kinase MRCK alpha isoform X13

    2. XM_011544306.3XP_011542608.1  serine/threonine-protein kinase MRCK alpha isoform X1

      Conserved Domains (8) summary
      pfam08826
      Location:881941
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:77343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:481791
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00029
      Location:10641113
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:11231257
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12831547
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    3. XM_017002581.2XP_016858070.1  serine/threonine-protein kinase MRCK alpha isoform X15

    4. XM_017002579.2XP_016858068.1  serine/threonine-protein kinase MRCK alpha isoform X13

    5. XM_005273324.3XP_005273381.1  serine/threonine-protein kinase MRCK alpha isoform X14

      UniProtKB/Swiss-Prot
      Q5VT25
      Related
      ENSP00000335341.6, ENST00000334218.9
      Conserved Domains (6) summary
      COG0419
      Location:432941
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00029
      Location:10131062
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:10721206
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12321496
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    6. XM_005273320.4XP_005273377.1  serine/threonine-protein kinase MRCK alpha isoform X7

      Conserved Domains (8) summary
      pfam08826
      Location:881941
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:77343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:481791
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00029
      Location:10131062
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:10721206
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12321496
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    7. XM_011544309.3XP_011542611.1  serine/threonine-protein kinase MRCK alpha isoform X11

      Conserved Domains (7) summary
      pfam08826
      Location:800860
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:77343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:9831032
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:10421176
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12021466
      CNH; CNH domain
      pfam15619
      Location:447614
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    8. XM_005273321.4XP_005273378.1  serine/threonine-protein kinase MRCK alpha isoform X9

      UniProtKB/Swiss-Prot
      Q5VT25
      Conserved Domains (8) summary
      pfam08826
      Location:881941
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:77343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:481791
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00029
      Location:10001049
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:10591193
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12191483
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    9. XM_005273322.4XP_005273379.1  serine/threonine-protein kinase MRCK alpha isoform X12

      UniProtKB/Swiss-Prot
      Q5VT25
      Conserved Domains (8) summary
      pfam08826
      Location:881941
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:77343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:481791
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00029
      Location:10351084
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:10941228
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12541518
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    10. XM_006711834.4XP_006711897.1  serine/threonine-protein kinase MRCK alpha isoform X4

      Conserved Domains (8) summary
      pfam08826
      Location:881941
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:77343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:481791
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00029
      Location:10351084
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:10941228
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12541518
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    11. XM_017002578.2XP_016858067.1  serine/threonine-protein kinase MRCK alpha isoform X10

    12. XM_005273318.4XP_005273375.1  serine/threonine-protein kinase MRCK alpha isoform X3

      Conserved Domains (8) summary
      pfam08826
      Location:881941
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:77343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:481791
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00029
      Location:10481097
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:11071241
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12671531
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    13. XM_006711835.4XP_006711898.1  serine/threonine-protein kinase MRCK alpha isoform X6

      Conserved Domains (8) summary
      pfam08826
      Location:881941
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:77343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:481791
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00029
      Location:10161065
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:10751209
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12351499
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    14. XM_005273317.4XP_005273374.1  serine/threonine-protein kinase MRCK alpha isoform X2

      Conserved Domains (8) summary
      pfam08826
      Location:881941
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:77343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:481791
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00029
      Location:10511100
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:11101244
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12701534
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    15. XM_011544307.3XP_011542609.1  serine/threonine-protein kinase MRCK alpha isoform X5

      Conserved Domains (8) summary
      pfam08826
      Location:881941
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:77343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:481791
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00029
      Location:10291078
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:10881222
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12481512
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    16. XM_011544308.3XP_011542610.1  serine/threonine-protein kinase MRCK alpha isoform X8

      Conserved Domains (8) summary
      pfam08826
      Location:881941
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:77343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:481791
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd01243
      Location:11231257
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00130
      Location:10641114
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:12831547
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    17. XM_017002582.2XP_016858071.1  serine/threonine-protein kinase MRCK alpha isoform X16

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