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    SORBS2 sorbin and SH3 domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 8470, updated on 19-Aug-2018

    Summary

    Official Symbol
    SORBS2provided by HGNC
    Official Full Name
    sorbin and SH3 domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:24098
    See related
    Ensembl:ENSG00000154556 MIM:616349; Vega:OTTHUMG00000157215
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARGBP2; PRO0618
    Summary
    Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in heart (RPKM 46.6), adrenal (RPKM 26.3) and 19 other tissues See more
    Orthologs

    Genomic context

    See SORBS2 in Genome Data Viewer
    Location:
    4q35.1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (185585444..185956716, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (186506598..186877870, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377590 Neighboring gene coiled-coil domain containing 110 Neighboring gene PDZ and LIM domain 3 Neighboring gene uncharacterized LOC101928929 Neighboring gene RNA, U4 small nuclear 64, pseudogene Neighboring gene toll like receptor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates SORBS2 in HeLa cells within 12 hours of exposure PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ93447, KIAA0777

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    cytoskeletal adaptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    structural constituent of muscle TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    biological_process ND
    No biological Data available
    more info
     
    cell growth involved in cardiac muscle cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    Z disc NAS
    Non-traceable Author Statement
    more info
    PubMed 
    actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    sorbin and SH3 domain-containing protein 2
    Names
    Arg binding protein 2
    Arg/Abl-interacting protein 2
    arg-binding protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029709.1 RefSeqGene

      Range
      5001..376273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145670.1NP_001139142.1  sorbin and SH3 domain-containing protein 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) originates from an alternate promoter and has a different 5'UTR and first coding exon compared to variant 1. The resulting protein isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797, AK225327, AL134289, BC011883, DA105517
      Consensus CDS
      CCDS47173.1
      UniProtKB/Swiss-Prot
      O94875
      Related
      ENSP00000397262.2, OTTHUMP00000211725, ENST00000449407.6, OTTHUMT00000347950
      Conserved Domains (3) summary
      smart00459
      Location:153198
      Sorb; Sorbin homologous domain
      cd11923
      Location:485541
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:584644
      SH3; Src Homology 3 domain superfamily
    2. NM_001145671.2NP_001139143.1  sorbin and SH3 domain-containing protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001139143.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) originates from an alternate promoter and has a different 5'UTR and first coding exon and includes alternate in-frame exons compared to variant 1. The resulting protein isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797, BC011883, DA119376
      Consensus CDS
      CCDS47174.1
      UniProtKB/Swiss-Prot
      O94875
      Related
      ENSP00000322182.9, OTTHUMP00000211726, ENST00000319471.13, OTTHUMT00000347951
      Conserved Domains (3) summary
      smart00459
      Location:153203
      Sorb; Sorbin homologous domain
      cd11923
      Location:572628
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:671731
      SH3; Src Homology 3 domain superfamily
    3. NM_001145672.1NP_001139144.1  sorbin and SH3 domain-containing protein 2 isoform 5

      See identical proteins and their annotated locations for NP_001139144.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) originates from an alternate promoter and has a different 5'UTR and first coding exon and includes alternate in-frame exons compared to variant 1. The resulting protein isoform (5) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797, AC104805, AK293400, AV658263, BC011883, CN340607, DA139168
      Consensus CDS
      CCDS54825.1
      UniProtKB/Swiss-Prot
      O94875
      Related
      ENSP00000409158.2, ENST00000448662.6
      Conserved Domains (3) summary
      smart00459
      Location:136186
      Sorb; Sorbin homologous domain
      cd11923
      Location:502558
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:601661
      SH3; Src Homology 3 domain superfamily
    4. NM_001145673.1NP_001139145.1  sorbin and SH3 domain-containing protein 2 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) originates from an alternate promoter and has a different 5'UTR and first coding exon and includes alternate in-frame exons compared to variant 1. The resulting protein isoform (6) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797, AK225812, AL134289, BC011883
      Consensus CDS
      CCDS47175.1
      UniProtKB/Swiss-Prot
      O94875
      Related
      ENSP00000396008.2, OTTHUMP00000211727, ENST00000437304.6, OTTHUMT00000347952
      Conserved Domains (3) summary
      smart00459
      Location:246296
      Sorb; Sorbin homologous domain
      cd11923
      Location:665721
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:764824
      SH3; Src Homology 3 domain superfamily
    5. NM_001145674.1NP_001139146.1  sorbin and SH3 domain-containing protein 2 isoform 7

      See identical proteins and their annotated locations for NP_001139146.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) originates from an alternate promoter and has a different 5'UTR and first coding exon compared to variant 1. The resulting protein isoform (7) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797, AK056628, AK296461, AV658263, CN340607, DA139168, DA836871
      Consensus CDS
      CCDS47176.1
      UniProtKB/Swiss-Prot
      O94875
      Related
      ENSP00000397482.1, ENST00000418609.5
      Conserved Domains (4) summary
      cd11917
      Location:9441004
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:845901
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl02617
      Location:829
      Sorb; Sorbin homologous domain
      cl17036
      Location:770824
      SH3; Src Homology 3 domain superfamily
    6. NM_001145675.1NP_001139147.1  sorbin and SH3 domain-containing protein 2 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) originates from an alternate promoter and has a different 5' UTR and first coding exon compared to variant 1. The resulting protein isoform (8) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797, AK304653, AV658263, CN340607, DA139168, DA836871, DC421607
      UniProtKB/TrEMBL
      B7Z997
      Conserved Domains (3) summary
      cd11923
      Location:333389
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl02617
      Location:436
      Sorb; Sorbin homologous domain
      cl17036
      Location:432492
      SH3; Src Homology 3 domain superfamily
    7. NM_001270771.1NP_001257700.1  sorbin and SH3 domain-containing protein 2 isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) originates from an alternate promoter, has a different 5' UTR, and several in-frame differences in the coding region compared to variant 1, which results in a longer isoform (7) compared to isoform 1.
      Source sequence(s)
      AB018320, AC093797, AK056628, BC035329, DA398113
      Consensus CDS
      CCDS59482.1
      UniProtKB/Swiss-Prot
      O94875
      Related
      ENSP00000347852.5, OTTHUMP00000211723, ENST00000355634.9, OTTHUMT00000347946
      Conserved Domains (4) summary
      smart00459
      Location:167217
      Sorb; Sorbin homologous domain
      cd11917
      Location:11401200
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:9661020
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10411097
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    8. NM_003603.6NP_003594.3  sorbin and SH3 domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_003594.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs at the 5' end, and contains a small in-frame insertion and a large in-frame deletion compared to transcript variant 2. It encodes a shorter isoform (1) with a different amino-terminal, but the same carboxy-terminal sequence containing three SH3 domains, as isoform 2.
      Source sequence(s)
      AC093797, AF049884, AK295742, BC011883, DA105517
      Consensus CDS
      CCDS43289.2
      UniProtKB/Swiss-Prot
      O94875
      UniProtKB/TrEMBL
      B7Z3D7
      Related
      ENSP00000377162.3, OTTHUMP00000211724, ENST00000393528.7, OTTHUMT00000347949
      Conserved Domains (3) summary
      smart00459
      Location:113163
      Sorb; Sorbin homologous domain
      cd11923
      Location:507563
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:606666
      SH3; Src Homology 3 domain superfamily
    9. NM_021069.4NP_066547.1  sorbin and SH3 domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_066547.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs at the 5' end, and contains a large in-frame insertion and a small in-frame deletion compared to transcript variant 1. It encodes a longer isoform (2) with a different amino-terminal, but the same carboxy-terminal sequence containing three SH3 domains, as isoform 1.
      Source sequence(s)
      AB018320, AC093797, AC096659
      Consensus CDS
      CCDS3845.1
      UniProtKB/Swiss-Prot
      O94875
      Related
      ENSP00000284776.7, OTTHUMP00000211722, ENST00000284776.11, OTTHUMT00000347944
      Conserved Domains (4) summary
      smart00459
      Location:67117
      Sorb; Sorbin homologous domain
      cd11917
      Location:10401100
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:941997
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:866920
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

      Range
      185585444..185956716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008756.2XP_016864245.1  sorbin and SH3 domain-containing protein 2 isoform X16

    2. XM_017008755.2XP_016864244.1  sorbin and SH3 domain-containing protein 2 isoform X15

      Conserved Domains (3) summary
      smart00459
      Location:113163
      Sorb; Sorbin homologous domain
      cd11923
      Location:460516
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:814874
      SH3; Src Homology 3 domain superfamily
    3. XM_024454258.1XP_024310026.1  sorbin and SH3 domain-containing protein 2 isoform X13

      Conserved Domains (3) summary
      smart00459
      Location:113163
      Sorb; Sorbin homologous domain
      cd11923
      Location:532588
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:886946
      SH3; Src Homology 3 domain superfamily
    4. XM_024454259.1XP_024310027.1  sorbin and SH3 domain-containing protein 2 isoform X14

      Conserved Domains (3) summary
      smart00459
      Location:67117
      Sorb; Sorbin homologous domain
      cd11923
      Location:461517
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:815875
      SH3; Src Homology 3 domain superfamily
    5. XM_017008771.2XP_016864260.1  sorbin and SH3 domain-containing protein 2 isoform X36

      UniProtKB/Swiss-Prot
      O94875
      Conserved Domains (3) summary
      smart00459
      Location:67117
      Sorb; Sorbin homologous domain
      cd11923
      Location:486542
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:585645
      SH3; Src Homology 3 domain superfamily
    6. XM_017008759.2XP_016864248.1  sorbin and SH3 domain-containing protein 2 isoform X20

    7. XM_017008768.2XP_016864257.1  sorbin and SH3 domain-containing protein 2 isoform X33

    8. XM_017008763.2XP_016864252.1  sorbin and SH3 domain-containing protein 2 isoform X29

    9. XM_017008758.2XP_016864247.1  sorbin and SH3 domain-containing protein 2 isoform X18

    10. XM_017008772.2XP_016864261.1  sorbin and SH3 domain-containing protein 2 isoform X37

    11. XM_024454260.1XP_024310028.1  sorbin and SH3 domain-containing protein 2 isoform X15

      Conserved Domains (3) summary
      smart00459
      Location:113163
      Sorb; Sorbin homologous domain
      cd11923
      Location:460516
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:814874
      SH3; Src Homology 3 domain superfamily
    12. XM_005263312.2XP_005263369.1  sorbin and SH3 domain-containing protein 2 isoform X26

      UniProtKB/Swiss-Prot
      O94875
      Related
      ENSP00000321983.6, OTTHUMP00000211728, ENST00000319454.10
      Conserved Domains (3) summary
      smart00459
      Location:113163
      Sorb; Sorbin homologous domain
      cd11923
      Location:532588
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:631691
      SH3; Src Homology 3 domain superfamily
    13. XM_017008770.2XP_016864259.1  sorbin and SH3 domain-containing protein 2 isoform X35

    14. XM_017008766.2XP_016864255.1  sorbin and SH3 domain-containing protein 2 isoform X32

      Conserved Domains (3) summary
      smart00459
      Location:136186
      Sorb; Sorbin homologous domain
      cd11923
      Location:483539
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:582642
      SH3; Src Homology 3 domain superfamily
    15. XM_006714390.2XP_006714453.1  sorbin and SH3 domain-containing protein 2 isoform X28

      See identical proteins and their annotated locations for XP_006714453.1

      UniProtKB/Swiss-Prot
      O94875
      Conserved Domains (3) summary
      smart00459
      Location:136186
      Sorb; Sorbin homologous domain
      cd11923
      Location:502558
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:601661
      SH3; Src Homology 3 domain superfamily
    16. XM_017008760.2XP_016864249.1  sorbin and SH3 domain-containing protein 2 isoform X22

    17. XM_017008769.2XP_016864258.1  sorbin and SH3 domain-containing protein 2 isoform X34

    18. XM_017008764.2XP_016864253.1  sorbin and SH3 domain-containing protein 2 isoform X31

    19. XM_005263310.2XP_005263367.1  sorbin and SH3 domain-containing protein 2 isoform X24

      Conserved Domains (3) summary
      smart00459
      Location:144194
      Sorb; Sorbin homologous domain
      cd11923
      Location:538594
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:637697
      SH3; Src Homology 3 domain superfamily
    20. XM_006714388.2XP_006714451.1  sorbin and SH3 domain-containing protein 2 isoform X21

      Conserved Domains (3) summary
      smart00459
      Location:144194
      Sorb; Sorbin homologous domain
      cd11923
      Location:563619
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:662722
      SH3; Src Homology 3 domain superfamily
    21. XM_005263313.2XP_005263370.1  sorbin and SH3 domain-containing protein 2 isoform X30

      Conserved Domains (3) summary
      smart00459
      Location:167212
      Sorb; Sorbin homologous domain
      cd11923
      Location:499555
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:598658
      SH3; Src Homology 3 domain superfamily
    22. XM_017008762.2XP_016864251.1  sorbin and SH3 domain-containing protein 2 isoform X27

    23. XM_005263311.2XP_005263368.1  sorbin and SH3 domain-containing protein 2 isoform X25

      Conserved Domains (3) summary
      smart00459
      Location:167217
      Sorb; Sorbin homologous domain
      cd11923
      Location:533589
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:632692
      SH3; Src Homology 3 domain superfamily
    24. XM_005263308.2XP_005263365.1  sorbin and SH3 domain-containing protein 2 isoform X19

      Conserved Domains (3) summary
      smart00459
      Location:167217
      Sorb; Sorbin homologous domain
      cd11923
      Location:586642
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:685745
      SH3; Src Homology 3 domain superfamily
    25. XM_005263307.2XP_005263364.1  sorbin and SH3 domain-containing protein 2 isoform X12

      Conserved Domains (4) summary
      smart00459
      Location:381431
      Sorb; Sorbin homologous domain
      cd11917
      Location:899959
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:800856
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:725779
      SH3; Src Homology 3 domain superfamily
    26. XM_017008754.2XP_016864243.1  sorbin and SH3 domain-containing protein 2 isoform X11

    27. XM_017008775.2XP_016864264.1  sorbin and SH3 domain-containing protein 2 isoform X39

    28. XM_017008753.2XP_016864242.1  sorbin and SH3 domain-containing protein 2 isoform X10

    29. XM_017008748.2XP_016864237.1  sorbin and SH3 domain-containing protein 2 isoform X5

    30. XM_024454257.1XP_024310025.1  sorbin and SH3 domain-containing protein 2 isoform X9

      Conserved Domains (5) summary
      smart00459
      Location:539589
      Sorb; Sorbin homologous domain
      cd11917
      Location:10041064
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:830884
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:905961
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl28144
      Location:622814
      Herpes_TK; Thymidine kinase from herpesvirus
    31. XM_017008752.2XP_016864241.1  sorbin and SH3 domain-containing protein 2 isoform X8

    32. XM_017008751.2XP_016864240.1  sorbin and SH3 domain-containing protein 2 isoform X7

    33. XM_017008750.2XP_016864239.1  sorbin and SH3 domain-containing protein 2 isoform X6

    34. XM_017008741.2XP_016864230.1  sorbin and SH3 domain-containing protein 2 isoform X2

    35. XM_017008767.2XP_016864256.1  sorbin and SH3 domain-containing protein 2 isoform X32

      Conserved Domains (3) summary
      smart00459
      Location:136186
      Sorb; Sorbin homologous domain
      cd11923
      Location:483539
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:582642
      SH3; Src Homology 3 domain superfamily
    36. XM_017008765.2XP_016864254.1  sorbin and SH3 domain-containing protein 2 isoform X31

    37. XM_017008757.1XP_016864246.1  sorbin and SH3 domain-containing protein 2 isoform X17

    38. XM_017008774.2XP_016864263.1  sorbin and SH3 domain-containing protein 2 isoform X38

    39. XM_017008773.2XP_016864262.1  sorbin and SH3 domain-containing protein 2 isoform X37

    40. XM_017008740.2XP_016864229.1  sorbin and SH3 domain-containing protein 2 isoform X1

    41. XM_017008743.2XP_016864232.1  sorbin and SH3 domain-containing protein 2 isoform X3

    42. XM_017008744.2XP_016864233.1  sorbin and SH3 domain-containing protein 2 isoform X4

    43. XM_017008739.2XP_016864228.1  sorbin and SH3 domain-containing protein 2 isoform X1

    44. XM_017008738.2XP_016864227.1  sorbin and SH3 domain-containing protein 2 isoform X1

    45. XM_017008761.2XP_016864250.1  sorbin and SH3 domain-containing protein 2 isoform X23

    RNA

    1. XR_002959769.1 RNA Sequence

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