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    RAB11FIP4 RAB11 family interacting protein 4 [ Homo sapiens (human) ]

    Gene ID: 84440, updated on 18-Nov-2018

    Summary

    Official Symbol
    RAB11FIP4provided by HGNC
    Official Full Name
    RAB11 family interacting protein 4provided by HGNC
    Primary source
    HGNC:HGNC:30267
    See related
    Ensembl:ENSG00000131242 MIM:611999; Vega:OTTHUMG00000132787
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FIP4-Rab11; RAB11-FIP4
    Summary
    The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]
    Expression
    Broad expression in brain (RPKM 25.4), testis (RPKM 6.0) and 17 other tissues See more
    Orthologs

    Genomic context

    See RAB11FIP4 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (31391624..31538217)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (29718642..29865232)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene neurofibromin 1 Neighboring gene NF1 intron 50 Alu-mediated recombination region Neighboring gene adenylate kinase 4 pseudogene 1 Neighboring gene uncharacterized LOC105371725 Neighboring gene RNA, 7SL, cytoplasmic 79, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 45, pseudogene Neighboring gene transfer RNA-Thr (CGT) 4-1 Neighboring gene microRNA 4724 Neighboring gene microRNA 193a

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ00131, KIAA1821, MGC11316, MGC126566

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ADP-ribosylation factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ADP-ribosylation factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Rab GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rab GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neural retina development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of G1 to G0 transition IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space HDA PubMed 
    midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rab11 family-interacting protein 4
    Names
    RAB11 family interacting protein 4 (class II)
    arfophilin-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051977.1 RefSeqGene

      Range
      5001..151594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001303542.2NP_001290471.2  rab11 family-interacting protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001290471.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks three 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB058724, AJ314646, AK097424, AL831830, BC047674, BI461640
      Consensus CDS
      CCDS76985.1
      UniProtKB/Swiss-Prot
      Q86YS3
      Related
      ENSP00000378227.2, OTTHUMP00000261059, ENST00000394744.6, OTTHUMT00000445580
      Conserved Domains (1) summary
      cl25732
      Location:238519
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_001346747.1NP_001333676.1  rab11 family-interacting protein 4 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC003101, KF510421
    3. NM_001346748.1NP_001333677.1  rab11 family-interacting protein 4 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC003101, AJ314646, KF510421
      UniProtKB/Swiss-Prot
      Q86YS3
      Conserved Domains (2) summary
      pfam09457
      Location:455495
      RBD-FIP; FIP domain
      cl25732
      Location:199480
      SMC_N; RecF/RecN/SMC N terminal domain
    4. NM_001346749.1NP_001333678.1  rab11 family-interacting protein 4 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC003101, AJ314646, BI461640, DA956442, KF510421
      UniProtKB/Swiss-Prot
      Q86YS3
      Conserved Domains (2) summary
      pfam09457
      Location:336376
      RBD-FIP; FIP domain
      cl25732
      Location:80361
      SMC_N; RecF/RecN/SMC N terminal domain
    5. NM_032932.5NP_116321.2  rab11 family-interacting protein 4 isoform 1

      See identical proteins and their annotated locations for NP_116321.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AJ314646, AY169244, BC047674, BC093914
      Consensus CDS
      CCDS11267.1
      UniProtKB/Swiss-Prot
      Q86YS3
      Related
      ENSP00000482620.1, OTTHUMP00000276558, ENST00000621161.4, OTTHUMT00000256195
      Conserved Domains (2) summary
      pfam13499
      Location:2076
      EF-hand_7; EF-hand domain pair
      cl25732
      Location:340621
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      31391624..31538217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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