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    ADGRA1 adhesion G protein-coupled receptor A1 [ Homo sapiens (human) ]

    Gene ID: 84435, updated on 18-Sep-2018

    Summary

    Official Symbol
    ADGRA1provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor A1provided by HGNC
    Primary source
    HGNC:HGNC:13838
    See related
    Ensembl:ENSG00000197177 MIM:612302; Vega:OTTHUMG00000019304
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR123
    Summary
    This gene encodes a protein that belongs to the adhesion family of G-protein-coupled receptors. Members of this family function in several sensory systems and regulate blood pressure, immune responses, food intake and development. A similar protein in rodents is thought to play a role in in the regulation of neuronal signaling pathways. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Mar 2014]
    Expression
    Biased expression in brain (RPKM 3.7), adrenal (RPKM 1.0) and 1 other tissue See more
    Orthologs

    Genomic context

    See ADGRA1 in Genome Data Viewer
    Location:
    10q26.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (133070929..133131675)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (134884433..134945179)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984283 Neighboring gene long intergenic non-protein coding RNA 1168 Neighboring gene uncharacterized LOC112268067 Neighboring gene adhesion G protein-coupled receptor A1 antisense RNA 1 Neighboring gene CEB36 minisatellite repeat instability region Neighboring gene ribosomal protein L5 pseudogene 28 Neighboring gene kinase non-catalytic C-lobe domain containing 1 Neighboring gene uncharacterized LOC105378574

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ25875, FLJ37356

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    adhesion G protein-coupled receptor A1
    Names
    G-protein coupled receptor 123
    probable G-protein coupled receptor 123

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034069.1 RefSeqGene

      Range
      5001..48672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083909.2NP_001077378.1  adhesion G protein-coupled receptor A1 isoform 1

      See identical proteins and their annotated locations for NP_001077378.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL445199, BC044247, DA208698, EF536972
      Consensus CDS
      CCDS41580.1
      UniProtKB/Swiss-Prot
      Q86SQ6
      Related
      ENSP00000376384.3, OTTHUMP00000196657, ENST00000392607.7, OTTHUMT00000051113
      Conserved Domains (1) summary
      cl21561
      Location:26294
      7tm_4; Olfactory receptor
    2. NM_001291085.1NP_001278014.1  adhesion G protein-coupled receptor A1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the use of an alternate promoter, contains a different 5' structure and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AB058731, AL445199, BC044247
      Consensus CDS
      CCDS76362.1
      UniProtKB/Swiss-Prot
      Q86SQ6
      Related
      ENSP00000376383.2, OTTHUMP00000196656, ENST00000392606.2, OTTHUMT00000051112
      Conserved Domains (2) summary
      cd14964
      Location:3753
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:1226
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

      Range
      133070929..133131675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005252695.1XP_005252752.1  adhesion G protein-coupled receptor A1 isoform X1

      UniProtKB/Swiss-Prot
      Q86SQ6
      Related
      ENSP00000475778.1, OTTHUMP00000273446, ENST00000607359.5, OTTHUMT00000316904
      Conserved Domains (1) summary
      cl21561
      Location:7461013
      7tm_4; Olfactory receptor
    2. XM_017016779.1XP_016872268.1  adhesion G protein-coupled receptor A1 isoform X3

      Conserved Domains (1) summary
      PHA03247
      Location:117250
      PHA03247; large tegument protein UL36; Provisional
    3. XM_011540273.1XP_011538575.1  adhesion G protein-coupled receptor A1 isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:326
      7tm_GPCRs; TM helix 5 [structural motif]
      cl28897
      Location:1154
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032422.2: Suppressed sequence

      Description
      NM_032422.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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