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    UXT ubiquitously expressed prefoldin like chaperone [ Homo sapiens (human) ]

    Gene ID: 8409, updated on 17-Jun-2019

    Summary

    Official Symbol
    UXTprovided by HGNC
    Official Full Name
    ubiquitously expressed prefoldin like chaperoneprovided by HGNC
    Primary source
    HGNC:HGNC:12641
    See related
    Ensembl:ENSG00000126756 MIM:300234
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STAP1; ART-27
    Summary
    The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Ubiquitous expression in bone marrow (RPKM 37.8), ovary (RPKM 37.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See UXT in Genome Data Viewer
    Location:
    Xp11.23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (47651792..47659180, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47511191..47518579, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene complement factor properdin Neighboring gene ETS transcription factor ELK1 Neighboring gene UXT antisense RNA 1 Neighboring gene CXXC finger protein 1 pseudogene 1 Neighboring gene spermine synthase pseudogene Neighboring gene zinc finger protein 585A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion transport along microtubule TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of G0 to G1 transition TAS
    Traceable Author Statement
    more info
     
    negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with gamma-tubulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with gamma-tubulin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle pole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein UXT
    Names
    SKP2-associated alpha PFD 1
    androgen receptor trapped clone 27 protein
    ubiquitously expressed transcript protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004182.3NP_004173.1  protein UXT isoform 2

      See identical proteins and their annotated locations for NP_004173.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AF092737, BQ681820, DA372561
      Consensus CDS
      CCDS14285.1
      UniProtKB/Swiss-Prot
      Q9UBK9
      Related
      ENSP00000327797.3, ENST00000333119.7
      Conserved Domains (1) summary
      cd00584
      Location:18147
      Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...
    2. NM_153477.3NP_705582.1  protein UXT isoform 1

      See identical proteins and their annotated locations for NP_705582.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF083242, BQ681820, DA372561
      Consensus CDS
      CCDS14284.1
      UniProtKB/Swiss-Prot
      Q9UBK9
      Related
      ENSP00000337393.2, ENST00000335890.3
      Conserved Domains (1) summary
      cd00584
      Location:30159
      Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...

    RNA

    1. NR_045559.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF083242, BM471483, BQ681820, DA372561
      Related
      ENST00000485641.5
    2. NR_045560.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BQ681820, DA372561, EL949569

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      47651792..47659180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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