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    KBTBD7 kelch repeat and BTB domain containing 7 [ Homo sapiens (human) ]

    Gene ID: 84078, updated on 8-Jul-2021

    Summary

    Official Symbol
    KBTBD7provided by HGNC
    Official Full Name
    kelch repeat and BTB domain containing 7provided by HGNC
    Primary source
    HGNC:HGNC:25266
    See related
    Ensembl:ENSG00000120696 MIM:617739
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a transcriptional activator, having been shown to increase the transcription of activator protein-1 and serum response element. The encoded protein can also form a complex with KBTBD6 and CUL3, which regulates the ubiquitylation and degradation of TIAM1, which is a regulator of RAC1. [provided by RefSeq, Jul 2016]
    Orthologs
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    Genomic context

    See KBTBD7 in Genome Data Viewer
    Location:
    13q14.11
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (41189834..41194569, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (41763970..41768705, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929140 Neighboring gene kelch repeat and BTB domain containing 6 Neighboring gene calmodulin 2 pseudogene 3 Neighboring gene mortality factor 4 like 1 pseudogene 4 Neighboring gene mitochondrial translation release factor 1 Neighboring gene Rac family small GTPase 1 pseudogene 3

    Genomic regions, transcripts, and products

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of kelch repeat and BTB (POZ) domain containing 7 (KBTBD7) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp434E2318

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    kelch repeat and BTB domain-containing protein 7
    Names
    kelch repeat and BTB (POZ) domain containing 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053142.1 RefSeqGene

      Range
      5016..9751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_032138.7NP_115514.2  kelch repeat and BTB domain-containing protein 7

      See identical proteins and their annotated locations for NP_115514.2

      Status: REVIEWED

      Source sequence(s)
      AI631319, AL354696, BC022033, BF436101, BU069965, BU070208, HY094395
      Consensus CDS
      CCDS9377.1
      UniProtKB/Swiss-Prot
      Q8WVZ9
      Related
      ENSP00000368797.3, ENST00000379483.4
      Conserved Domains (4) summary
      PHA03098
      Location:55544
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:384421
      Kelch; KELCH repeat [structural motif]
      cd18273
      Location:37178
      BTB_POZ_KBTBD6_7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7
      cd18482
      Location:168270
      BACK_KBTBD6_7; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      41189834..41194569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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