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    OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF [ Homo sapiens (human) ]

    Gene ID: 84033, updated on 12-Aug-2018

    Summary

    Official Symbol
    OBSCNprovided by HGNC
    Official Full Name
    obscurin, cytoskeletal calmodulin and titin-interacting RhoGEFprovided by HGNC
    Primary source
    HGNC:HGNC:15719
    See related
    Ensembl:ENSG00000154358 MIM:608616; Vega:OTTHUMG00000039772
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UNC89; ARHGEF30
    Summary
    The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in heart (RPKM 8.6), prostate (RPKM 2.9) and 15 other tissues See more
    Orthologs

    Genomic context

    See OBSCN in Genome Data Viewer
    Location:
    1q42.13
    Exon count:
    121
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (228201321..228381431)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228395740..228566577)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene IBA57 divergent transcript Neighboring gene IBA57, iron-sulfur cluster assembly Neighboring gene OBSCN antisense RNA 1 Neighboring gene MAGE-like protein 2 Neighboring gene tripartite motif containing 11 Neighboring gene microRNA 6742 Neighboring gene tripartite motif containing 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
      Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
    • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
      NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
    • Regulation of RhoA activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of RhoA activity, organism-specific biosystem
      Regulation of RhoA activity
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
      p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ14124, KIAA1556, KIAA1639, MGC120409, MGC120410, MGC120411, MGC120412, MGC138590, DKFZp666E245

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    Rho guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    ankyrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    structural constituent of muscle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    titin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    protein localization to M-band ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    sarcomere organization TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    M band ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Z disc ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    myofibril NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nuclear body IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    obscurin
    Names
    obscurin, myosin light chain kinase
    obscurin-MLCK
    NP_001092093.2
    NP_001258152.2
    NP_443075.3
    XP_005273344.1
    XP_005273348.1
    XP_005273355.1
    XP_005273364.1
    XP_006711885.1
    XP_006711886.1
    XP_006711890.1
    XP_006711892.1
    XP_011542599.1
    XP_011542601.1
    XP_016857932.1
    XP_016857933.1
    XP_016857934.1
    XP_016857935.1
    XP_016857936.1
    XP_016857937.1
    XP_016857938.1
    XP_016857939.1
    XP_016857940.1
    XP_016857941.1
    XP_016857942.1
    XP_016857943.1
    XP_016857944.1
    XP_016857945.1
    XP_016857946.1
    XP_016857947.1
    XP_016857948.1
    XP_016857949.1
    XP_016857950.1
    XP_016857951.1
    XP_016857952.1
    XP_016857953.1
    XP_016857954.1
    XP_016857955.1
    XP_016857956.1
    XP_016857957.1
    XP_016857958.1
    XP_016857959.1
    XP_016857960.1
    XP_016857961.1
    XP_016857962.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032122.1 RefSeqGene

      Range
      4971..175715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001098623.2NP_001092093.2  obscurin isoform b

      See identical proteins and their annotated locations for NP_001092093.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and the 3' coding region, compared to variant 1. The resulting isoform (b) contains a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AL353593, AL359510, AL670729
      Consensus CDS
      CCDS58065.1
      UniProtKB/Swiss-Prot
      Q5VST9
      Related
      ENSP00000409493.1, ENST00000422127.5
      Conserved Domains (15) summary
      cd00096
      Location:51435213
      Ig; Immunoglobulin domain
      smart00408
      Location:74777543
      IGc2; Immunoglobulin C-2 Type
      cd12025
      Location:56025664
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:75577635
      FN3; Fibronectin type 3 domain
      smart00220
      Location:64686721
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00410
      Location:248328
      IG_like; Immunoglobulin like
      cd00063
      Location:45234608
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1099
      I-set; Immunoglobulin I-set domain
      cd13239
      Location:58826006
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      cd14107
      Location:64656721
      STKc_obscurin_rpt1; Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin
      cd14110
      Location:76687924
      STKc_obscurin_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin
      pfam00047
      Location:811872
      ig; Immunoglobulin domain
      pfam13895
      Location:31013181
      Ig_2; Immunoglobulin domain
      cl02571
      Location:56975873
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:991
      Ig; Immunoglobulin domain
    2. NM_001271223.2NP_001258152.2  obscurin isoform IC

      Status: REVIEWED

      Description
      Transcript Variant: This variant (IC) represents an inferred complete model that includes additional in-frame coding exons with consensus splice sites. The exons included in this inferred variant are supported by a combination of available cDNA data and sequence analysis of repetitive exons. This transcript represents a predicted protein (isoform IC) of 8,923 amino acids.
      Source sequence(s)
      AL353593, AL359510, AL670729
      Consensus CDS
      CCDS59204.1
      UniProtKB/TrEMBL
      A6NGQ3
      Related
      ENSP00000455507.2, ENST00000570156.6
      Conserved Domains (16) summary
      cd00096
      Location:61006170
      Ig; Immunoglobulin domain
      smart00408
      Location:84348500
      IGc2; Immunoglobulin C-2 Type
      cd12025
      Location:65596621
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:85148592
      FN3; Fibronectin type 3 domain
      smart00220
      Location:74257678
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:46794754
      IG; Immunoglobulin
      smart00410
      Location:248328
      IG_like; Immunoglobulin like
      cd00063
      Location:54805565
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1099
      I-set; Immunoglobulin I-set domain
      cd13239
      Location:68396963
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      cd14107
      Location:74227678
      STKc_obscurin_rpt1; Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin
      cd14110
      Location:86258879
      STKc_obscurin_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin
      pfam00047
      Location:811872
      ig; Immunoglobulin domain
      pfam13895
      Location:35303610
      Ig_2; Immunoglobulin domain
      cl02571
      Location:66546830
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:991
      Ig; Immunoglobulin domain
    3. NM_052843.3NP_443075.3  obscurin isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript, and encodes the shorter isoform (a).
      Source sequence(s)
      AL353593, AL359510, AL670729
      Consensus CDS
      CCDS1570.2
      UniProtKB/Swiss-Prot
      Q5VST9
      Related
      ENSP00000284548.11, OTTHUMP00000037764, ENST00000284548.15, OTTHUMT00000095986
      Conserved Domains (14) summary
      cd00096
      Location:51435213
      Ig; Immunoglobulin domain
      smart00015
      Location:48724893
      IQ; Calmodulin-binding motif
      smart00408
      Location:61216189
      IGc2; Immunoglobulin C-2 Type
      cd12025
      Location:56025664
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00409
      Location:28342911
      IG; Immunoglobulin
      smart00410
      Location:248328
      IG_like; Immunoglobulin like
      cd00063
      Location:45234608
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1099
      I-set; Immunoglobulin I-set domain
      cd13239
      Location:58826006
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      pfam00047
      Location:811872
      ig; Immunoglobulin domain
      pfam00169
      Location:58966000
      PH; PH domain
      pfam13895
      Location:31013181
      Ig_2; Immunoglobulin domain
      cl02571
      Location:56975873
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:991
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      228201321..228381431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002470.2XP_016857959.1  obscurin isoform X34

    2. XM_017002443.2XP_016857932.1  obscurin isoform X1

    3. XM_017002445.2XP_016857934.1  obscurin isoform X2

    4. XM_017002446.2XP_016857935.1  obscurin isoform X3

    5. XM_017002447.2XP_016857936.1  obscurin isoform X4

    6. XM_017002461.2XP_016857950.1  obscurin isoform X21

    7. XM_005273287.5XP_005273344.1  obscurin isoform X5

      Conserved Domains (16) summary
      cd00096
      Location:62006270
      Ig; Immunoglobulin domain
      smart00408
      Location:85368602
      IGc2; Immunoglobulin C-2 Type
      cd12025
      Location:66596721
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:86168694
      FN3; Fibronectin type 3 domain
      smart00220
      Location:75277780
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:45874662
      IG; Immunoglobulin
      smart00410
      Location:248328
      IG_like; Immunoglobulin like
      cd00063
      Location:55805665
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1099
      I-set; Immunoglobulin I-set domain
      cd13239
      Location:69407064
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      cd14107
      Location:75247780
      STKc_obscurin_rpt1; Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin
      cd14110
      Location:87278983
      STKc_obscurin_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin
      pfam00047
      Location:811872
      ig; Immunoglobulin domain
      pfam13895
      Location:34383518
      Ig_2; Immunoglobulin domain
      cl02571
      Location:67546931
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:991
      Ig; Immunoglobulin domain
    8. XM_005273291.5XP_005273348.1  obscurin isoform X6

      Conserved Domains (16) summary
      cd00096
      Location:61886258
      Ig; Immunoglobulin domain
      smart00408
      Location:85248590
      IGc2; Immunoglobulin C-2 Type
      cd12025
      Location:66476709
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:86048682
      FN3; Fibronectin type 3 domain
      smart00220
      Location:75157768
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:45874662
      IG; Immunoglobulin
      smart00410
      Location:248328
      IG_like; Immunoglobulin like
      cd00063
      Location:55685653
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1099
      I-set; Immunoglobulin I-set domain
      cd13239
      Location:69287052
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      cd14107
      Location:75127768
      STKc_obscurin_rpt1; Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin
      cd14110
      Location:87158971
      STKc_obscurin_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin
      pfam00047
      Location:811872
      ig; Immunoglobulin domain
      pfam13895
      Location:34383518
      Ig_2; Immunoglobulin domain
      cl02571
      Location:67426919
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:991
      Ig; Immunoglobulin domain
    9. XM_006711822.4XP_006711885.1  obscurin isoform X24

      Conserved Domains (16) summary
      cd00096
      Location:60086078
      Ig; Immunoglobulin domain
      smart00408
      Location:83448410
      IGc2; Immunoglobulin C-2 Type
      cd12025
      Location:64676529
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:84248502
      FN3; Fibronectin type 3 domain
      smart00220
      Location:73357588
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:248328
      IG; Immunoglobulin
      smart00410
      Location:31713248
      IG_like; Immunoglobulin like
      cd00063
      Location:53885473
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1099
      I-set; Immunoglobulin I-set domain
      cd13239
      Location:67486872
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      cd14107
      Location:73327588
      STKc_obscurin_rpt1; Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin
      cd14110
      Location:85358791
      STKc_obscurin_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin
      pfam00047
      Location:811872
      ig; Immunoglobulin domain
      pfam13895
      Location:34383518
      Ig_2; Immunoglobulin domain
      cl02571
      Location:65626739
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:991
      Ig; Immunoglobulin domain
    10. XM_006711823.4XP_006711886.1  obscurin isoform X26

      Conserved Domains (16) summary
      cd00096
      Location:60086078
      Ig; Immunoglobulin domain
      smart00408
      Location:83428408
      IGc2; Immunoglobulin C-2 Type
      cd12025
      Location:64676529
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:84228500
      FN3; Fibronectin type 3 domain
      smart00220
      Location:73337586
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:248328
      IG; Immunoglobulin
      smart00410
      Location:31713248
      IG_like; Immunoglobulin like
      cd00063
      Location:53885473
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1099
      I-set; Immunoglobulin I-set domain
      cd13239
      Location:67476871
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      cd14107
      Location:73307586
      STKc_obscurin_rpt1; Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin
      cd14110
      Location:85338789
      STKc_obscurin_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin
      pfam00047
      Location:811872
      ig; Immunoglobulin domain
      pfam13895
      Location:34383518
      Ig_2; Immunoglobulin domain
      cl02571
      Location:65626738
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:991
      Ig; Immunoglobulin domain
    11. XM_017002464.2XP_016857953.1  obscurin isoform X25

    12. XM_005273298.5XP_005273355.1  obscurin isoform X17

      Conserved Domains (16) summary
      cd00096
      Location:60976167
      Ig; Immunoglobulin domain
      smart00408
      Location:84338499
      IGc2; Immunoglobulin C-2 Type
      cd12025
      Location:65566618
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:85138591
      FN3; Fibronectin type 3 domain
      smart00220
      Location:74247677
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:45874662
      IG; Immunoglobulin
      smart00410
      Location:248328
      IG_like; Immunoglobulin like
      cd00063
      Location:54775562
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1099
      I-set; Immunoglobulin I-set domain
      cd13239
      Location:68376961
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      cd14107
      Location:74217677
      STKc_obscurin_rpt1; Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin
      cd14110
      Location:86248880
      STKc_obscurin_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin
      pfam00047
      Location:811872
      ig; Immunoglobulin domain
      pfam13895
      Location:34383518
      Ig_2; Immunoglobulin domain
      cl02571
      Location:66516828
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:991
      Ig; Immunoglobulin domain
    13. XM_005273307.5XP_005273364.1  obscurin isoform X31

      Conserved Domains (16) summary
      cd00096
      Location:58265896
      Ig; Immunoglobulin domain
      smart00408
      Location:81628228
      IGc2; Immunoglobulin C-2 Type
      cd12025
      Location:62856347
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:82428320
      FN3; Fibronectin type 3 domain
      smart00220
      Location:71537406
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:19171994
      IG; Immunoglobulin
      smart00410
      Location:248328
      IG_like; Immunoglobulin like
      cd00063
      Location:52065291
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1099
      I-set; Immunoglobulin I-set domain
      cd13239
      Location:65666690
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      cd14107
      Location:71507406
      STKc_obscurin_rpt1; Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin
      cd14110
      Location:83538609
      STKc_obscurin_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin
      pfam00047
      Location:811872
      ig; Immunoglobulin domain
      pfam13895
      Location:34383518
      Ig_2; Immunoglobulin domain
      cl02571
      Location:63806557
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:991
      Ig; Immunoglobulin domain
    14. XM_017002459.2XP_016857948.1  obscurin isoform X19

    15. XM_017002449.2XP_016857938.1  obscurin isoform X8

    16. XM_017002450.2XP_016857939.1  obscurin isoform X9

    17. XM_017002458.2XP_016857947.1  obscurin isoform X18

    18. XM_017002465.2XP_016857954.1  obscurin isoform X27

    19. XM_017002469.2XP_016857958.1  obscurin isoform X32

    20. XM_011544297.3XP_011542599.1  obscurin isoform X33

      Conserved Domains (16) summary
      cd00096
      Location:54805550
      Ig; Immunoglobulin domain
      smart00408
      Location:78147880
      IGc2; Immunoglobulin C-2 Type
      cd12025
      Location:59396001
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:78947972
      FN3; Fibronectin type 3 domain
      smart00220
      Location:68057058
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:19171994
      IG; Immunoglobulin
      smart00410
      Location:248328
      IG_like; Immunoglobulin like
      cd00063
      Location:48604945
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1099
      I-set; Immunoglobulin I-set domain
      cd13239
      Location:62196343
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      cd14107
      Location:68027058
      STKc_obscurin_rpt1; Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin
      cd14110
      Location:80058261
      STKc_obscurin_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin
      pfam00047
      Location:811872
      ig; Immunoglobulin domain
      pfam13895
      Location:34383518
      Ig_2; Immunoglobulin domain
      cl02571
      Location:60346210
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:991
      Ig; Immunoglobulin domain
    21. XM_017002466.2XP_016857955.1  obscurin isoform X28

    22. XM_017002468.2XP_016857957.1  obscurin isoform X30

    23. XM_017002452.2XP_016857941.1  obscurin isoform X11

    24. XM_017002467.2XP_016857956.1  obscurin isoform X29

    25. XM_017002451.2XP_016857940.1  obscurin isoform X10

    26. XM_017002460.2XP_016857949.1  obscurin isoform X20

    27. XM_017002453.2XP_016857942.1  obscurin isoform X12

    28. XM_017002463.2XP_016857952.1  obscurin isoform X23

    29. XM_017002455.2XP_016857944.1  obscurin isoform X14

    30. XM_017002457.2XP_016857946.1  obscurin isoform X16

    31. XM_017002454.2XP_016857943.1  obscurin isoform X13

    32. XM_017002456.2XP_016857945.1  obscurin isoform X15

    33. XM_011544299.3XP_011542601.1  obscurin isoform X39

      Conserved Domains (16) summary
      cd00096
      Location:53885458
      Ig; Immunoglobulin domain
      smart00408
      Location:77227788
      IGc2; Immunoglobulin C-2 Type
      cd12025
      Location:58475909
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:78027880
      FN3; Fibronectin type 3 domain
      smart00220
      Location:67136966
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:18251902
      IG; Immunoglobulin
      smart00410
      Location:248328
      IG_like; Immunoglobulin like
      cd00063
      Location:47684853
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1099
      I-set; Immunoglobulin I-set domain
      cd13239
      Location:61276251
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      cd14107
      Location:67106966
      STKc_obscurin_rpt1; Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin
      cd14110
      Location:79138169
      STKc_obscurin_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin
      pfam00047
      Location:811872
      ig; Immunoglobulin domain
      pfam13895
      Location:33463426
      Ig_2; Immunoglobulin domain
      cl02571
      Location:59426118
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:991
      Ig; Immunoglobulin domain
    34. XM_017002462.2XP_016857951.1  obscurin isoform X22

    35. XM_017002448.2XP_016857937.1  obscurin isoform X7

    36. XM_017002444.2XP_016857933.1  obscurin isoform X1

    37. XM_017002473.2XP_016857962.1  obscurin isoform X37

    38. XM_017002471.2XP_016857960.1  obscurin isoform X35

    39. XM_017002472.2XP_016857961.1  obscurin isoform X36

    40. XM_006711827.4XP_006711890.1  obscurin isoform X38

      Conserved Domains (14) summary
      cd00096
      Location:54805550
      Ig; Immunoglobulin domain
      smart00015
      Location:52095230
      IQ; Calmodulin-binding motif
      smart00408
      Location:64586526
      IGc2; Immunoglobulin C-2 Type
      cd12025
      Location:59396001
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00409
      Location:31713248
      IG; Immunoglobulin
      smart00410
      Location:248328
      IG_like; Immunoglobulin like
      cd00063
      Location:48604945
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1099
      I-set; Immunoglobulin I-set domain
      cd13239
      Location:62196343
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      pfam00047
      Location:811872
      ig; Immunoglobulin domain
      pfam00169
      Location:62336337
      PH; PH domain
      pfam13895
      Location:34383518
      Ig_2; Immunoglobulin domain
      cl02571
      Location:60346210
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:991
      Ig; Immunoglobulin domain
    41. XM_006711829.4XP_006711892.1  obscurin isoform X40

      Conserved Domains (14) summary
      cd00096
      Location:53885458
      Ig; Immunoglobulin domain
      smart00015
      Location:51175138
      IQ; Calmodulin-binding motif
      smart00408
      Location:63666434
      IGc2; Immunoglobulin C-2 Type
      cd12025
      Location:58475909
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00409
      Location:30793156
      IG; Immunoglobulin
      smart00410
      Location:248328
      IG_like; Immunoglobulin like
      cd00063
      Location:47684853
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1099
      I-set; Immunoglobulin I-set domain
      cd13239
      Location:61276251
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      pfam00047
      Location:811872
      ig; Immunoglobulin domain
      pfam00169
      Location:61416245
      PH; PH domain
      pfam13895
      Location:33463426
      Ig_2; Immunoglobulin domain
      cl02571
      Location:59426118
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:991
      Ig; Immunoglobulin domain

    RNA

    1. XR_001737476.2 RNA Sequence

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