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    SNX25 sorting nexin 25 [ Homo sapiens (human) ]

    Gene ID: 83891, updated on 8-Dec-2018

    Summary

    Official Symbol
    SNX25provided by HGNC
    Official Full Name
    sorting nexin 25provided by HGNC
    Primary source
    HGNC:HGNC:21883
    See related
    Ensembl:ENSG00000109762
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SBBI31; MSTP043
    Expression
    Broad expression in lung (RPKM 10.3), thyroid (RPKM 5.9) and 24 other tissues See more
    Orthologs

    Genomic context

    See SNX25 in Genome Data Viewer
    Location:
    4q35.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (185204237..185368020)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (186130773..186285120)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2436 Neighboring gene uncharacterized LOC105377588 Neighboring gene solute carrier family 25 member 4 Neighboring gene cilia and flagella associated protein 97 Neighboring gene uncharacterized LOC107986206 Neighboring gene LRP2 binding protein Neighboring gene ankyrin repeat domain 37 Neighboring gene UFM1 specific peptidase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ23161

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    type I transforming growth factor beta receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317781.1NP_001304710.1  sorting nexin-25

      Status: VALIDATED

      Source sequence(s)
      AA626308, AC073344, AF113223, AY601647
      Consensus CDS
      CCDS34116.1
      UniProtKB/Swiss-Prot
      Q9H3E2
      Related
      ENSP00000426255.1, ENST00000504273.5
      Conserved Domains (4) summary
      cd06878
      Location:502624
      PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
      cd08720
      Location:291399
      RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
      pfam02194
      Location:2160
      PXA; PXA domain
      pfam08628
      Location:701807
      Nexin_C; Sorting nexin C terminal

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

      Range
      185204237..185368020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532308.3XP_011530610.1  sorting nexin-25 isoform X8

      Conserved Domains (4) summary
      cd08720
      Location:488596
      RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
      pfam02194
      Location:166324
      PXA; PXA domain
      pfam08628
      Location:843949
      Nexin_C; Sorting nexin C terminal
      cl02563
      Location:699801
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    2. XM_011532302.3XP_011530604.1  sorting nexin-25 isoform X1

      Conserved Domains (4) summary
      cd06878
      Location:711833
      PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
      cd08720
      Location:500608
      RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
      pfam02194
      Location:166324
      PXA; PXA domain
      pfam08628
      Location:9101016
      Nexin_C; Sorting nexin C terminal
    3. XM_011532303.3XP_011530605.1  sorting nexin-25 isoform X2

      Conserved Domains (4) summary
      cd06878
      Location:710832
      PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
      cd08720
      Location:499607
      RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
      pfam02194
      Location:166324
      PXA; PXA domain
      pfam08628
      Location:9091015
      Nexin_C; Sorting nexin C terminal
    4. XM_011532304.3XP_011530606.1  sorting nexin-25 isoform X3

      Conserved Domains (4) summary
      cd06878
      Location:699821
      PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
      cd08720
      Location:488596
      RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
      pfam02194
      Location:166324
      PXA; PXA domain
      pfam08628
      Location:8981004
      Nexin_C; Sorting nexin C terminal
    5. XM_011532305.3XP_011530607.1  sorting nexin-25 isoform X4

      Conserved Domains (4) summary
      cd06878
      Location:678800
      PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
      cd08720
      Location:467575
      RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
      pfam02194
      Location:166324
      PXA; PXA domain
      pfam08628
      Location:877983
      Nexin_C; Sorting nexin C terminal
    6. XM_005263267.5XP_005263324.1  sorting nexin-25 isoform X6

      Conserved Domains (4) summary
      cd06878
      Location:666788
      PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
      cd08720
      Location:455563
      RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
      pfam02194
      Location:166324
      PXA; PXA domain
      pfam08628
      Location:865971
      Nexin_C; Sorting nexin C terminal
    7. XM_011532306.2XP_011530608.1  sorting nexin-25 isoform X5

      Conserved Domains (4) summary
      cd06878
      Location:711833
      PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
      cd08720
      Location:500608
      RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
      pfam02194
      Location:166324
      PXA; PXA domain
      pfam08628
      Location:910989
      Nexin_C; Sorting nexin C terminal
    8. XM_017008680.1XP_016864169.1  sorting nexin-25 isoform X7

    9. XM_017008687.1XP_016864176.1  sorting nexin-25 isoform X14

    10. XM_017008686.1XP_016864175.1  sorting nexin-25 isoform X13

    11. XM_017008684.2XP_016864173.1  sorting nexin-25 isoform X10

    12. XM_017008683.2XP_016864172.1  sorting nexin-25 isoform X9

    13. XM_024454240.1XP_024310008.1  sorting nexin-25 isoform X11

      Related
      ENSP00000483653.1, ENST00000618785.4
      Conserved Domains (3) summary
      cd06878
      Location:285407
      PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
      cd08720
      Location:74182
      RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
      pfam08628
      Location:484590
      Nexin_C; Sorting nexin C terminal
    14. XM_017008685.2XP_016864174.1  sorting nexin-25 isoform X12

    RNA

    1. XR_938776.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_031953.2: Suppressed sequence

      Description
      NM_031953.2: This RefSeq was removed because currently there is insufficient support for the transcript.
    Support Center