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    COG3 component of oligomeric golgi complex 3 [ Homo sapiens (human) ]

    Gene ID: 83548, updated on 24-Nov-2020

    Summary

    Official Symbol
    COG3provided by HGNC
    Official Full Name
    component of oligomeric golgi complex 3provided by HGNC
    Primary source
    HGNC:HGNC:18619
    See related
    Ensembl:ENSG00000136152 MIM:606975
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SEC34
    Summary
    This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.[provided by RefSeq, Jun 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 12.6), prostate (RPKM 12.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See COG3 in Genome Data Viewer
    Location:
    13q14.13
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109.20201120 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (45464916..45536701)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (46039030..46110833)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 30 Neighboring gene SLC25A30 antisense RNA 1 Neighboring gene peptidylprolyl isomerase A pseudogene 25 Neighboring gene glutamate rich 6B Neighboring gene RNA, 5S ribosomal pseudogene 27 Neighboring gene TIMM9 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of component of oligomeric golgi complex 3 (COG3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endoplasmic reticulum to Golgi vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum to Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
     
    intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intra-Golgi vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to organelle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi transport complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cis-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    trans-Golgi network membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    conserved oligomeric Golgi complex subunit 3
    Names
    COG complex subunit 3
    p94
    tethering factor SEC34
    vesicle-docking protein SEC34 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031431.4NP_113619.3  conserved oligomeric Golgi complex subunit 3

      Status: REVIEWED

      Source sequence(s)
      AL139326, AL606514
      Consensus CDS
      CCDS9398.1
      Related
      ENSP00000258654.8, ENST00000349995.10
      Conserved Domains (1) summary
      pfam04136
      Location:131274
      Sec34; Sec34-like family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      45464916..45536701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535267.3XP_011533569.1  conserved oligomeric Golgi complex subunit 3 isoform X2

      Conserved Domains (1) summary
      pfam04136
      Location:131274
      Sec34; Sec34-like family
    2. XM_011535266.2XP_011533568.1  conserved oligomeric Golgi complex subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_011533568.1

      Conserved Domains (1) summary
      pfam04136
      Location:150
      Sec34; Sec34-like family

    RNA

    1. XR_429222.4 RNA Sequence

    2. XR_001749695.2 RNA Sequence

    3. XR_001749696.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001204476.1: Suppressed sequence

      Description
      NM_001204476.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
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