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    FCRL5 Fc receptor like 5 [ Homo sapiens (human) ]

    Gene ID: 83416, updated on 13-Feb-2019

    Summary

    Official Symbol
    FCRL5provided by HGNC
    Official Full Name
    Fc receptor like 5provided by HGNC
    Primary source
    HGNC:HGNC:18508
    See related
    Ensembl:ENSG00000143297 MIM:605877
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820
    Summary
    This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
    Expression
    Biased expression in lymph node (RPKM 14.3), spleen (RPKM 11.3) and 8 other tissues See more
    Orthologs

    Genomic context

    See FCRL5 in Genome Data Viewer
    Location:
    1q23.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (157513377..157552533, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157483167..157522310, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371456 Neighboring gene uncharacterized LOC105371455 Neighboring gene SLAM family member 5 Neighboring gene Fc receptor like 4 Neighboring gene uncharacterized LOC105371457

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ00333, FLJ00397, MGC119590, MGC119592, MGC119593, DKFZp667F216, DKFZp667E2019

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Fc receptor-like protein 5
    Names
    fc receptor homolog 5
    fcR-like protein 5
    immune receptor translocation-associated protein 2
    immunoglobulin superfamily receptor translocation associated 2 (IRTA2)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027723.1 RefSeqGene

      Range
      5001..44144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001195388.1NP_001182317.1  Fc receptor-like protein 5 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 3' coding region, resulting in frame-shift, as compared to variant 1. The resulting isoform (2) has a different and longer C-terminus, as compared to isoform 1.
      Source sequence(s)
      AF369794, AL353899, BC101067, BC101068
      UniProtKB/Swiss-Prot
      Q96RD9
      Conserved Domains (4) summary
      cd05752
      Location:23100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:577652
      IG_like; Immunoglobulin like
      pfam13895
      Location:105185
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:565638
      Ig_3; Immunoglobulin domain
    2. NM_031281.3NP_112571.2  Fc receptor-like protein 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_112571.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the dominant isoform (1).
      Source sequence(s)
      AF369794, AL353899, BC101067, BE676280
      Consensus CDS
      CCDS1165.1
      UniProtKB/Swiss-Prot
      Q96RD9
      Related
      ENSP00000354691.3, ENST00000361835.7
      Conserved Domains (4) summary
      cd05752
      Location:23100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:577652
      IG_like; Immunoglobulin like
      pfam13895
      Location:105185
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:565638
      Ig_3; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      157513377..157552533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510032.2XP_011508334.1  Fc receptor-like protein 5 isoform X3

      Conserved Domains (4) summary
      cd05752
      Location:23100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:484559
      IG_like; Immunoglobulin like
      pfam13895
      Location:105185
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:472545
      Ig_3; Immunoglobulin domain
    2. XM_011510031.2XP_011508333.1  Fc receptor-like protein 5 isoform X2

      Conserved Domains (4) summary
      cd05752
      Location:23100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:577652
      IG_like; Immunoglobulin like
      pfam13895
      Location:105185
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:565638
      Ig_3; Immunoglobulin domain
    3. XM_011510030.2XP_011508332.1  Fc receptor-like protein 5 isoform X1

      Conserved Domains (3) summary
      smart00410
      Location:492567
      IG_like; Immunoglobulin like
      pfam13895
      Location:20100
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:480553
      Ig_3; Immunoglobulin domain
    4. XM_011510033.2XP_011508335.1  Fc receptor-like protein 5 isoform X4

      Related
      ENSP00000357173.3, ENST00000368190.7
      Conserved Domains (4) summary
      cd05752
      Location:23100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:577652
      IG_like; Immunoglobulin like
      pfam13895
      Location:105185
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:565638
      Ig_3; Immunoglobulin domain
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