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    CAPZA2 capping actin protein of muscle Z-line subunit alpha 2 [ Homo sapiens (human) ]

    Gene ID: 830, updated on 5-Sep-2021

    Summary

    Official Symbol
    CAPZA2provided by HGNC
    Official Full Name
    capping actin protein of muscle Z-line subunit alpha 2provided by HGNC
    Primary source
    HGNC:HGNC:1490
    See related
    Ensembl:ENSG00000198898 MIM:601571
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAPZ; CAPPA2
    Summary
    The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 60.8), urinary bladder (RPKM 54.1) and 25 other tissues See more
    Orthologs
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    Genomic context

    See CAPZA2 in Genome Data Viewer
    Location:
    7q31.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (116862587..116922049)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (116502641..116562103)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene MET proto-oncogene, receptor tyrosine kinase Neighboring gene greater CFTR locus negative regulatory element CR8 Neighboring gene HNF1 motif-containing MPRA enhancer 7 Neighboring gene RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing pseudogene Neighboring gene greater CFTR locus negative regulatory element CR9 Neighboring gene uncharacterized LOC105375465 Neighboring gene CRISPRi-validated cis-regulatory element chr7.4218 Neighboring gene RNA, 5S ribosomal pseudogene 239

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein-containing complex assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of F-actin capping protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in brush border IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cortical cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    F-actin-capping protein subunit alpha-2
    Names
    F-actin capping protein alpha-2 subunit
    capZ alpha-2
    capping actin protein of muscle Z-line alpha subunit 2
    capping protein (actin filament) muscle Z-line, alpha 2
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006136.3NP_006127.1  F-actin-capping protein subunit alpha-2

      See identical proteins and their annotated locations for NP_006127.1

      Status: REVIEWED

      Source sequence(s)
      AC002543, BC005338, BI553815, BX386541, U03851
      Consensus CDS
      CCDS5768.1
      UniProtKB/Swiss-Prot
      P47755
      UniProtKB/TrEMBL
      A4D0V4
      Related
      ENSP00000354947.2, ENST00000361183.8
      Conserved Domains (1) summary
      pfam01267
      Location:17283
      F-actin_cap_A; F-actin capping protein alpha subunit

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      116862587..116922049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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