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    CAB39L calcium binding protein 39 like [ Homo sapiens (human) ]

    Gene ID: 81617, updated on 13-Feb-2019

    Summary

    Official Symbol
    CAB39Lprovided by HGNC
    Official Full Name
    calcium binding protein 39 likeprovided by HGNC
    Primary source
    HGNC:HGNC:20290
    See related
    Ensembl:ENSG00000102547 MIM:612175
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MO2L; MO25-BETA; bA103J18.3
    Expression
    Broad expression in prostate (RPKM 17.8), adrenal (RPKM 15.4) and 23 other tissues See more
    Orthologs

    Genomic context

    See CAB39L in Genome Data Viewer
    Location:
    13q14.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (49308650..49444851, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (49882786..50018221, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370203 Neighboring gene cytidine and dCMP deaminase domain containing 1 Neighboring gene SETDB2-PHF11 readthrough Neighboring gene SET domain bifurcated histone lysine methyltransferase 2 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 14 Neighboring gene PHD finger protein 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • AMPK signaling pathway, organism-specific biosystem (from KEGG)
      AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • AMPK signaling pathway, conserved biosystem (from KEGG)
      AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem (from REACTOME)
      Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystemUpon formation of a trimeric LKB1:STRAD:MO25 complex, LKB1 phosphorylates and activates AMPK. This phosphorylation is immediately removed in basal conditions by PP2C, but if the cellular AMP:ATP rati...
    • IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
      IGF1R signaling cascade, organism-specific biosystemAfter autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activ...
    • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
      IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
    • IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
      IRS-related events triggered by IGF1R, organism-specific biosystemThe phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et a...
    • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
      Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
    • PI3K Cascade, organism-specific biosystem (from REACTOME)
      PI3K Cascade, organism-specific biosystem
      PI3K Cascade
    • PKB-mediated events, organism-specific biosystem (from REACTOME)
      PKB-mediated events, organism-specific biosystemPKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
      Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
    • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
      Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signalling, organism-specific biosystem (from REACTOME)
      mTOR signalling, organism-specific biosystemTarget of rapamycin (mTOR) is a highly-conserved serine/threonine kinase that regulates cell growth and division in response to energy levels, growth signals, and nutrients (Zoncu et al. 2011). Contr...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ12577

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle arrest TAS
    Traceable Author Statement
    more info
     
    signal transduction by protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    calcium-binding protein 39-like
    Names
    MO25beta
    U937-associated antigen
    antigen MLAA-34
    mo25-like protein
    sarcoma antigen NY-SAR-79

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079670.3NP_001073138.1  calcium-binding protein 39-like

      See identical proteins and their annotated locations for NP_001073138.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a 5' non-coding exon compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AL138875, AW134845, BC010993, BX647518, DB051338
      Consensus CDS
      CCDS9416.2
      UniProtKB/Swiss-Prot
      Q9H9S4
      UniProtKB/TrEMBL
      A0A024RDT3
      Related
      ENSP00000386375.1, ENST00000409308.5
      Conserved Domains (1) summary
      pfam08569
      Location:61324
      Mo25; Mo25-like
    2. NM_001287337.1NP_001274266.1  calcium-binding protein 39-like

      See identical proteins and their annotated locations for NP_001274266.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-5 encode the same protein.
      Source sequence(s)
      AL138875, AW134845, AY211923, AY288977, BX647518, DB051338
      Consensus CDS
      CCDS9416.2
      UniProtKB/Swiss-Prot
      Q9H9S4
      UniProtKB/TrEMBL
      A0A024RDT3, Q86WE6
      Related
      ENSP00000386328.1, ENST00000410043.5
      Conserved Domains (1) summary
      pfam08569
      Location:61324
      Mo25; Mo25-like
    3. NM_001287338.1NP_001274267.1  calcium-binding protein 39-like

      See identical proteins and their annotated locations for NP_001274267.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains 3 alternate 5' non-coding exons compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AL138875, AW134845, AY211923, BX647518, DB033467, DB457246, HY043965
      Consensus CDS
      CCDS9416.2
      UniProtKB/Swiss-Prot
      Q9H9S4
      UniProtKB/TrEMBL
      A0A024RDT3, Q86WE6
      Related
      ENSP00000479669.1, ENST00000610540.4
      Conserved Domains (1) summary
      pfam08569
      Location:61324
      Mo25; Mo25-like
    4. NM_001287339.1NP_001274268.1  calcium-binding protein 39-like

      See identical proteins and their annotated locations for NP_001274268.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks couple of exons, and contains two alternate exons in the 5' non-coding region compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AL138875, AW134845, AY211923, BX647518, DB457246
      Consensus CDS
      CCDS9416.2
      UniProtKB/Swiss-Prot
      Q9H9S4
      UniProtKB/TrEMBL
      A0A024RDT3, Q86WE6
      Related
      ENSP00000261669.7, ENST00000347776.9
      Conserved Domains (1) summary
      pfam08569
      Location:61324
      Mo25; Mo25-like
    5. NM_030925.3NP_112187.2  calcium-binding protein 39-like

      See identical proteins and their annotated locations for NP_112187.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks several exons, and contains an alternate exon in the 5' non-coding region compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AL138875, AW134845, AY211923, BC010993, BX647518, DB279812
      Consensus CDS
      CCDS9416.2
      UniProtKB/Swiss-Prot
      Q9H9S4
      UniProtKB/TrEMBL
      A0A024RDT3, Q86WE6
      Related
      ENSP00000348113.4, ENST00000355854.8
      Conserved Domains (1) summary
      pfam08569
      Location:61324
      Mo25; Mo25-like

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

      Range
      49308650..49444851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535256.3XP_011533558.1  calcium-binding protein 39-like isoform X1

      See identical proteins and their annotated locations for XP_011533558.1

      UniProtKB/Swiss-Prot
      Q9H9S4
      UniProtKB/TrEMBL
      A0A024RDT3
      Conserved Domains (1) summary
      pfam08569
      Location:61324
      Mo25; Mo25-like
    2. XM_017020786.2XP_016876275.1  calcium-binding protein 39-like isoform X1

      UniProtKB/Swiss-Prot
      Q9H9S4
      UniProtKB/TrEMBL
      A0A024RDT3
      Conserved Domains (1) summary
      pfam08569
      Location:61324
      Mo25; Mo25-like
    3. XM_011535254.3XP_011533556.1  calcium-binding protein 39-like isoform X1

      See identical proteins and their annotated locations for XP_011533556.1

      UniProtKB/Swiss-Prot
      Q9H9S4
      UniProtKB/TrEMBL
      A0A024RDT3
      Conserved Domains (1) summary
      pfam08569
      Location:61324
      Mo25; Mo25-like
    4. XM_017020788.2XP_016876277.1  calcium-binding protein 39-like isoform X1

      UniProtKB/Swiss-Prot
      Q9H9S4
      UniProtKB/TrEMBL
      A0A024RDT3
      Conserved Domains (1) summary
      pfam08569
      Location:61324
      Mo25; Mo25-like
    5. XM_017020787.2XP_016876276.1  calcium-binding protein 39-like isoform X1

      UniProtKB/Swiss-Prot
      Q9H9S4
      UniProtKB/TrEMBL
      A0A024RDT3
      Conserved Domains (1) summary
      pfam08569
      Location:61324
      Mo25; Mo25-like
    6. XM_017020785.2XP_016876274.1  calcium-binding protein 39-like isoform X1

      UniProtKB/Swiss-Prot
      Q9H9S4
      UniProtKB/TrEMBL
      A0A024RDT3
      Conserved Domains (1) summary
      pfam08569
      Location:61324
      Mo25; Mo25-like
    7. XM_011535255.3XP_011533557.1  calcium-binding protein 39-like isoform X1

      See identical proteins and their annotated locations for XP_011533557.1

      UniProtKB/Swiss-Prot
      Q9H9S4
      UniProtKB/TrEMBL
      A0A024RDT3
      Conserved Domains (1) summary
      pfam08569
      Location:61324
      Mo25; Mo25-like
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