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    PLA2G12A phospholipase A2 group XIIA [ Homo sapiens (human) ]

    Gene ID: 81579, updated on 2-Oct-2018

    Summary

    Official Symbol
    PLA2G12Aprovided by HGNC
    Official Full Name
    phospholipase A2 group XIIAprovided by HGNC
    Primary source
    HGNC:HGNC:18554
    See related
    Ensembl:ENSG00000123739 MIM:611652; Vega:OTTHUMG00000131915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GXII; ROSSY; PLA2G12
    Summary
    Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 11.6), prostate (RPKM 9.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See PLA2G12A in Genome Data Viewer
    Location:
    4q25
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (109709989..109730086, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (110631145..110651242, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene mitochondrial calcium uniporter dominant negative beta subunit Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 14 Neighboring gene caspase 6 Neighboring gene complement factor I Neighboring gene GAR1 ribonucleoprotein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
    env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-dependent phospholipase A2 activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    phospholipase A2 activity TAS
    Traceable Author Statement
    more info
     
    phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    arachidonic acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    biological_process ND
    No biological Data available
    more info
     
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    phosphatidylcholine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    phosphatidylethanolamine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    phosphatidylglycerol acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    phosphatidylinositol acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    phosphatidylserine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    group XIIA secretory phospholipase A2
    Names
    GXII sPLA2
    group XII secreted phospholipase A2
    group XIIA secreted phospholipase A2
    phosphatidylcholine 2-acylhydrolase 12A
    phospholipase A2, group XII
    sPLA2-XII
    NP_110448.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030821.4NP_110448.2  group XIIA secretory phospholipase A2 precursor

      See identical proteins and their annotated locations for NP_110448.2

      Status: VALIDATED

      Source sequence(s)
      AC004067, BC017218, BI667755
      Consensus CDS
      CCDS3686.1
      UniProtKB/Swiss-Prot
      Q9BZM1
      UniProtKB/TrEMBL
      Q542Y6
      Related
      ENSP00000243501.5, OTTHUMP00000162744, ENST00000243501.9, OTTHUMT00000254868
      Conserved Domains (1) summary
      pfam06951
      Location:24189
      PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

      Range
      109709989..109730086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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