U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    WDR82 WD repeat domain 82 [ Homo sapiens (human) ]

    Gene ID: 80335, updated on 17-Jun-2024

    Summary

    Official Symbol
    WDR82provided by HGNC
    Official Full Name
    WD repeat domain 82provided by HGNC
    Primary source
    HGNC:HGNC:28826
    See related
    Ensembl:ENSG00000164091 MIM:611059; AllianceGenome:HGNC:28826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SWD2; MST107; WDR82A; MSTP107; PRO2730; TMEM113; PRO34047
    Summary
    TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]
    Expression
    Ubiquitous expression in brain (RPKM 35.2), endometrium (RPKM 34.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See WDR82 in Genome Data Viewer
    Location:
    3p21.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (52254434..52278649, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (52287321..52311534, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52288450..52312665, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19933 Neighboring gene NANOG hESC enhancer GRCh37_chr3:52274848-52275376 Neighboring gene TWF2 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14435 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14436 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1M Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19934 Neighboring gene microRNA let-7g Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:52311392-52312024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14437 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52312657-52313288 Neighboring gene uncharacterized LOC107986086 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:52321476-52322675 Neighboring gene GLYCTK antisense RNA 1 Neighboring gene glycerate kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
    EBI GWAS Catalog
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Depletion of WD repeat domain 82 (WDR82) by siRNA enhances HIV-1 Tat activation of HIV-1 LTR, which is not the results of increased Tat expression and release of CDK9/CCNT1 from 7SK snRNP, and activation of NF-kappaB PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of PTW/PP1 phosphatase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Set1C/COMPASS complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Set1C/COMPASS complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of histone methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    WD repeat-containing protein 82
    Names
    transmembrane protein 113

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025222.4NP_079498.2  WD repeat-containing protein 82

      See identical proteins and their annotated locations for NP_079498.2

      Status: VALIDATED

      Source sequence(s)
      AC092045, AI478905, AK098435, AY358264, DB500464
      Consensus CDS
      CCDS2851.2
      UniProtKB/Swiss-Prot
      A8K5R5, Q6UXN9, Q8TEB2
      Related
      ENSP00000296490.3, ENST00000296490.8
      Conserved Domains (2) summary
      cd00200
      Location:15300
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:2461
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      52254434..52278649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534136.3XP_011532438.1  WD repeat-containing protein 82 isoform X1

      Related
      ENSP00000420779.2, ENST00000469000.6
      Conserved Domains (3) summary
      COG2319
      Location:7223
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:3068
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:7220
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      52287321..52311534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348023.1XP_054203998.1  WD repeat-containing protein 82 isoform X1