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    CALCR calcitonin receptor [ Homo sapiens (human) ]

    Gene ID: 799, updated on 22-Jun-2018
    Official Symbol
    CALCRprovided by HGNC
    Official Full Name
    calcitonin receptorprovided by HGNC
    Primary source
    HGNC:HGNC:1440
    See related
    Ensembl:ENSG00000004948 MIM:114131; Vega:OTTHUMG00000023599
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRT; CTR; CT-R; CTR1
    Summary
    This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    See CALCR in Genome Data Viewer
    Location:
    7q21.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (93424487..93574730, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (93053799..93204042, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene HEPACAM family member 2 Neighboring gene VPS50, EARP/GARPII complex subunit Neighboring gene microRNA 653 Neighboring gene microRNA 489 Neighboring gene uncharacterized LOC105375400 Neighboring gene ribosomal protein S27 pseudogene 17 Neighboring gene microRNA 4652

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Postmenopausal osteoporosis
    MedGen: C0029458 OMIM: 166710 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat and RANKL/M-CSF enhance osteoclast differentiation and activity by increasing osteoclast differentiation markers, such as cathepsin K and calcitonin receptor PubMed

    Go to the HIV-1, Human Interaction Database

    • Calcitonin-like ligand receptors, organism-specific biosystem (from REACTOME)
      Calcitonin-like ligand receptors, organism-specific biosystemThe calcitonin peptide family comprises calcitonin, amylin, calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and intermedin (AM2). Calcitonin is a 32 amino acid peptide, involved in bone h...
    • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
      Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway, organism-specific biosystem (from WikiPathways)
      RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway, organism-specific biosystemRANKL (Receptor activator of nuclear factor-kappa B ligand), RANK (Receptor activator of nuclear factor-kappa B) and the natural decoy receptor of RANKL, OPG (Osteoprotegerin) are three important mol...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    CONTRIBUTES_TO amylin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to amylin receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    amylin receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    calcitonin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT calcitonin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcitonin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    calcitonin gene-related peptide receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    calcitonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcitonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    NOT activation of adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-activating G-protein coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    amylin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    amylin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cross-receptor inhibition within G-protein coupled receptor heterodimer IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of calcium ion import across plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein kinase A signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein kinase B signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to glucocorticoid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    amylin receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013005.1 RefSeqGene

      Range
      5001..155244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001164737.2NP_001158209.2  calcitonin receptor isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC003078, AK313996, L00587
      Consensus CDS
      CCDS55125.1
      Related
      ENSP00000352561.2, ENST00000359558.6
    2. NM_001164738.1NP_001158210.1  calcitonin receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001158210.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AB022178, AC003078
      Consensus CDS
      CCDS5631.1
      UniProtKB/Swiss-Prot
      P30988
      UniProtKB/TrEMBL
      A0A0C4DG16
      Related
      ENSP00000377959.1, OTTHUMP00000162535, ENST00000394441.5, OTTHUMT00000254661
      Conserved Domains (2) summary
      pfam00002
      Location:145387
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:69137
      HRM; Hormone receptor domain
    3. NM_001742.3NP_001733.1  calcitonin receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001733.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC003078, AC005024, AK313996
      Consensus CDS
      CCDS5631.1
      UniProtKB/Swiss-Prot
      P30988
      UniProtKB/TrEMBL
      A0A0C4DG16
      Related
      ENSP00000389295.1, OTTHUMP00000208686, ENST00000426151.5, OTTHUMT00000341744
      Conserved Domains (2) summary
      pfam00002
      Location:145387
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:69137
      HRM; Hormone receptor domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      Range
      93424487..93574730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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