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    CALCR calcitonin receptor [ Homo sapiens (human) ]

    Gene ID: 799, updated on 1-Aug-2020

    Summary

    Official Symbol
    CALCRprovided by HGNC
    Official Full Name
    calcitonin receptorprovided by HGNC
    Primary source
    HGNC:HGNC:1440
    See related
    Ensembl:ENSG00000004948 MIM:114131
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRT; CTR; CT-R; CTR1
    Summary
    This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See CALCR in Genome Data Viewer
    Location:
    7q21.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (93424486..93574730, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (93053799..93204042, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene HEPACAM family member 2 Neighboring gene VPS50 subunit of EARP/GARPII complex Neighboring gene microRNA 653 Neighboring gene microRNA 489 Neighboring gene uncharacterized LOC105375400 Neighboring gene ribosomal protein S27 pseudogene 17 Neighboring gene microRNA 4652

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Postmenopausal osteoporosis
    MedGen: C0029458 OMIM: 166710 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat and RANKL/M-CSF enhance osteoclast differentiation and activity by increasing osteoclast differentiation markers, such as cathepsin K and calcitonin receptor PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to amylin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to amylin receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    amylin receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    amyloid-beta binding IC
    Inferred by Curator
    more info
    PubMed 
    calcitonin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT calcitonin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcitonin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    calcitonin gene-related peptide receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    calcitonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    NOT activation of adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    adenylate cyclase-activating G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    amylin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    amylin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cross-receptor inhibition within G protein-coupled receptor heterodimer IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of calcium ion import across plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein kinase A signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein kinase B signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to amyloid-beta IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to glucocorticoid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    amylin receptor complex 1 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    amylin receptor complex 2 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    amylin receptor complex 3 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013005.1 RefSeqGene

      Range
      5001..155245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001164737.2NP_001158209.2  calcitonin receptor isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC003078, AK313996, L00587
      Consensus CDS
      CCDS55125.1
      Related
      ENSP00000497687.1, ENST00000649521.1
      Conserved Domains (2) summary
      pfam02793
      Location:69137
      HRM; Hormone receptor domain
      cd15274
      Location:145424
      7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    2. NM_001164738.1NP_001158210.1  calcitonin receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001158210.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AB022178, AC003078
      Consensus CDS
      CCDS5631.1
      UniProtKB/Swiss-Prot
      P30988
      UniProtKB/TrEMBL
      A0A0C4DG16
      Related
      ENSP00000377959.1, ENST00000394441.5
      Conserved Domains (2) summary
      pfam00002
      Location:145387
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:69137
      HRM; Hormone receptor domain
    3. NM_001742.4NP_001733.1  calcitonin receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001733.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC003078, AC005024, AK313996
      Consensus CDS
      CCDS5631.1
      UniProtKB/Swiss-Prot
      P30988
      UniProtKB/TrEMBL
      A0A0C4DG16
      Related
      ENSP00000389295.1, ENST00000426151.6
      Conserved Domains (2) summary
      pfam00002
      Location:145387
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:69137
      HRM; Hormone receptor domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      93424486..93574730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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