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    DHRS12 dehydrogenase/reductase 12 [ Homo sapiens (human) ]

    Gene ID: 79758, updated on 13-Feb-2019

    Summary

    Official Symbol
    DHRS12provided by HGNC
    Official Full Name
    dehydrogenase/reductase 12provided by HGNC
    Primary source
    HGNC:HGNC:25832
    See related
    Ensembl:ENSG00000102796 MIM:616163
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SDR40C1
    Summary
    This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
    Expression
    Ubiquitous expression in fat (RPKM 3.8), kidney (RPKM 3.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See DHRS12 in Genome Data Viewer
    Location:
    13q14.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (51767993..51804162, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (52330614..52379667, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 413, pseudogene Neighboring gene WD repeat and FYVE domain containing 2 Neighboring gene ATP synthase peripheral stalk-membrane subunit b pseudogene 1 Neighboring gene uncharacterized LOC107984561 Neighboring gene transmembrane protein 272 Neighboring gene coiled-coil domain containing 70

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ13639

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dehydrogenase/reductase SDR family member 12
    Names
    dehydrogenase/reductase (SDR family) member 12
    short-chain dehydrogenase/reductase family 40C member 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031719.2NP_001026889.1  dehydrogenase/reductase SDR family member 12 isoform 1

      See identical proteins and their annotated locations for NP_001026889.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      BC009825, DB481446, R60032
      Consensus CDS
      CCDS31976.1
      UniProtKB/Swiss-Prot
      A0PJE2
      Related
      ENSP00000280056.2, ENST00000280056.6
      Conserved Domains (1) summary
      cl25409
      Location:33186
      SDR; Short-chain dehydrogenases/reductases (SDR)
    2. NM_001270424.1NP_001257353.1  dehydrogenase/reductase SDR family member 12 isoform 3

      See identical proteins and their annotated locations for NP_001257353.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region and 3' UTR, including the use of an upstream start codon, compared to variant 1. The resulting protein (isoform 3) has distinct N- and C-termini and is longer than isoform 1.
      Source sequence(s)
      AA831151, BC026024, DB481446
      Consensus CDS
      CCDS58292.1
      UniProtKB/Swiss-Prot
      A0PJE2
      Related
      ENSP00000411565.2, ENST00000444610.6
      Conserved Domains (2) summary
      cd09808
      Location:40293
      DHRS-12_like_SDR_c-like; human dehydrogenase/reductase SDR family member (DHRS)-12/FLJ13639-like, classical (c)-like SDRs
      PRK06138
      Location:40298
      PRK06138; short chain dehydrogenase; Provisional
    3. NM_024705.2NP_078981.1  dehydrogenase/reductase SDR family member 12 isoform 2

      See identical proteins and their annotated locations for NP_078981.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA831151, AK023701, DB481446
      Consensus CDS
      CCDS9430.1
      UniProtKB/Swiss-Prot
      A0PJE2
      Related
      ENSP00000218981.1, ENST00000218981.5
      Conserved Domains (1) summary
      cl21454
      Location:33232
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

      Range
      51767993..51804162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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