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    ADIPOR2 adiponectin receptor 2 [ Homo sapiens (human) ]

    Gene ID: 79602, updated on 12-Aug-2018

    Summary

    Official Symbol
    ADIPOR2provided by HGNC
    Official Full Name
    adiponectin receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:24041
    See related
    Ensembl:ENSG00000006831 MIM:607946; Vega:OTTHUMG00000130139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAQR2; ACDCR2
    Summary
    The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in fat (RPKM 49.9), adrenal (RPKM 34.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See ADIPOR2 in Genome Data Viewer
    Location:
    12p13.33
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (1691027..1788679)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (1800147..1897845)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Wnt family member 5B Neighboring gene F-box and leucine rich repeat protein 14 Neighboring gene microRNA 3649 Neighboring gene SDA1 domain containing 1 pseudogene Neighboring gene ribosomal protein S4X pseudogene 14 Neighboring gene uncharacterized LOC105369602 Neighboring gene uncharacterized LOC105369601 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • AMP-activated Protein Kinase (AMPK) Signaling, organism-specific biosystem (from WikiPathways)
      AMP-activated Protein Kinase (AMPK) Signaling, organism-specific biosystemAMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gam...
    • AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem (from REACTOME)
      AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystemAMP-activated protein kinase (AMPK) is a sensor of cellular energy levels. A high cellular ratio of AMP:ATP triggers the phosphorylation and activation of AMPK. Activated AMPK in turn phosphorylates ...
    • AMPK signaling pathway, organism-specific biosystem (from KEGG)
      AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • AMPK signaling pathway, conserved biosystem (from KEGG)
      AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
      Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
      Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
      Integration of energy metabolism, organism-specific biosystemMany hormones that affect individual physiological processes including the regulation of appetite, absorption, transport, and oxidation of foodstuffs influence energy metabolism pathways. While insul...
    • Longevity regulating pathway, organism-specific biosystem (from KEGG)
      Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC4640, FLJ21432

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    adipokinetic hormone receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adiponectin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    adiponectin-activated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adiponectin-activated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fatty acid oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    hormone-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of fatty acid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    vascular wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    adiponectin receptor protein 2
    Names
    progestin and adipoQ receptor family member 2
    progestin and adipoQ receptor family member II

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024551.2NP_078827.2  adiponectin receptor protein 2

      See identical proteins and their annotated locations for NP_078827.2

      Status: VALIDATED

      Source sequence(s)
      AK128511, BC004906, BC051858, BM973815
      Consensus CDS
      CCDS8511.1
      UniProtKB/Swiss-Prot
      Q86V24
      Related
      ENSP00000349616.4, OTTHUMP00000160634, ENST00000357103.4, OTTHUMT00000252447
      Conserved Domains (1) summary
      pfam03006
      Location:140363
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      1691027..1788679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005253789.2XP_005253846.1  adiponectin receptor protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005253846.1

      UniProtKB/Swiss-Prot
      Q86V24
      Conserved Domains (1) summary
      pfam03006
      Location:140363
      HlyIII; Haemolysin-III related
    2. XM_006719018.2XP_006719081.1  adiponectin receptor protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006719081.1

      UniProtKB/Swiss-Prot
      Q86V24
      Conserved Domains (1) summary
      pfam03006
      Location:140363
      HlyIII; Haemolysin-III related
    3. XM_011521024.2XP_011519326.1  adiponectin receptor protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011519326.1

      UniProtKB/Swiss-Prot
      Q86V24
      Conserved Domains (1) summary
      pfam03006
      Location:140363
      HlyIII; Haemolysin-III related

    Reference GRCh38.p12 PATCHES

    Genomic

    1. NW_018654718.1 Reference GRCh38.p12 PATCHES

      Range
      33225..130823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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