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    Arf6 ADP-ribosylation factor 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79121, updated on 10-Jul-2024

    Summary

    Official Symbol
    Arf6provided by RGD
    Official Full Name
    ADP-ribosylation factor 6provided by RGD
    Primary source
    RGD:621279
    See related
    EnsemblRapid:ENSRNOG00000070951 AllianceGenome:RGD:621279
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl ribonucleotide binding activity; protein N-terminus binding activity; and thioesterase binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; maintenance of postsynaptic density structure; and negative regulation of dendrite development. Located in endosome; plasma membrane; and ruffle. Is active in glutamatergic synapse. Orthologous to human ARF6 (ADP ribosylation factor 6). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See Arf6 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (93589777..93590925)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (87853742..87854890)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (91697109..91698257)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene kelch domain containing 2 Neighboring gene nuclear export mediator factor Neighboring gene microRNA mir-3084a-4 Neighboring gene uncharacterized LOC134479213 Neighboring gene uncharacterized LOC102548223 Neighboring gene uncharacterized LOC102548030 Neighboring gene uncharacterized LOC120103545

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thioesterase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nerve growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cortical actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytic recycling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within erythrocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment of epithelial cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hepatocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within liver development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of postsynaptic density structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in maintenance of postsynaptic density structure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of focal adhesion disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of keratinocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic cytokinetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to endosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of dendritic spine development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of presynapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of presynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Flemming body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Flemming body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cleavage furrow ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in exocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ADP-ribosylation factor 6
    NP_077066.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024152.2NP_077066.1  ADP-ribosylation factor 6

      See identical proteins and their annotated locations for NP_077066.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091146
      UniProtKB/Swiss-Prot
      P62332, Q5BKA5
      UniProtKB/TrEMBL
      A0A8L2Q237, A6HBW5
      Related
      ENSRNOP00000099834.1, ENSRNOT00000173547.1
      Conserved Domains (1) summary
      smart00177
      Location:1175
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      93589777..93590925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)