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    ZYX zyxin [ Homo sapiens (human) ]

    Gene ID: 7791, updated on 9-Dec-2018

    Summary

    Official Symbol
    ZYXprovided by HGNC
    Official Full Name
    zyxinprovided by HGNC
    Primary source
    HGNC:HGNC:13200
    See related
    Ensembl:ENSG00000159840 MIM:602002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESP-2; HED-2
    Summary
    Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 122.6), lung (RPKM 100.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZYX in Genome Data Viewer
    Location:
    7q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (143381227..143391111)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143078338..143088204)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928397 Neighboring gene family with sequence similarity 131 member B Neighboring gene uncharacterized LOC100507507 Neighboring gene microRNA 6892 Neighboring gene EPH receptor A1 Neighboring gene EPHA1 antisense RNA 1 Neighboring gene taste 2 receptor member 62 pseudogene Neighboring gene taste 2 receptor member 60

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of zyxin (ZYX) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Yeast two hybrid assay identifies the HIV-1 Nef-interacting protein zyxin. HIV-1 Nef co-localizes with zyxin in the cortical regions of human podocyte PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • E-cadherin signaling in keratinocytes, organism-specific biosystem (from Pathway Interaction Database)
      E-cadherin signaling in keratinocytes, organism-specific biosystem
      E-cadherin signaling in keratinocytes
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem (from Pathway Interaction Database)
      Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem
      Stabilization and expansion of the E-cadherin adherens junction

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-matrix adhesion IC
    Inferred by Curator
    more info
    PubMed 
    cellular response to interferon-gamma IEA
    Inferred from Electronic Annotation
    more info
     
    integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    focal adhesion HDA PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010972.1NP_001010972.1  zyxin isoform 1

      See identical proteins and their annotated locations for NP_001010972.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      BC008743, BC009360, BC017183, BU844538
      Consensus CDS
      CCDS5883.1
      UniProtKB/Swiss-Prot
      Q15942
      UniProtKB/TrEMBL
      Q96AF9
      Conserved Domains (4) summary
      cd09349
      Location:351437
      LIM1_Zyxin; The first LIM domain of Zyxin
      cd09435
      Location:504570
      LIM3_Zyxin; The third LIM domain of Zyxin
      cl02475
      Location:444503
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl25764
      Location:201365
      PAT1; Topoisomerase II-associated protein PAT1
    2. NM_001362783.1NP_001349712.1  zyxin isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK298925, BC008743, BM857080
      Conserved Domains (3) summary
      cd09435
      Location:473539
      LIM3_Zyxin; The third LIM domain of Zyxin
      cl02475
      Location:320406
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl25764
      Location:170334
      PAT1; Topoisomerase II-associated protein PAT1
    3. NM_003461.5NP_003452.1  zyxin isoform 1

      See identical proteins and their annotated locations for NP_003452.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      BC008743
      Consensus CDS
      CCDS5883.1
      UniProtKB/Swiss-Prot
      Q15942
      UniProtKB/TrEMBL
      Q96AF9
      Related
      ENSP00000324422.5, ENST00000322764.9
      Conserved Domains (4) summary
      cd09349
      Location:351437
      LIM1_Zyxin; The first LIM domain of Zyxin
      cd09435
      Location:504570
      LIM3_Zyxin; The third LIM domain of Zyxin
      cl02475
      Location:444503
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl25764
      Location:201365
      PAT1; Topoisomerase II-associated protein PAT1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      Range
      143381227..143391111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012587.2XP_016868076.1  zyxin isoform X1

      Conserved Domains (3) summary
      cd09349
      Location:410496
      LIM1_Zyxin; The first LIM domain of Zyxin
      cd09435
      Location:563629
      LIM3_Zyxin; The third LIM domain of Zyxin
      cl02475
      Location:503562
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    2. XM_011516569.2XP_011514871.2  zyxin isoform X2

      Related
      ENSP00000346417.4, ENST00000354434.8
      Conserved Domains (3) summary
      cd09435
      Location:473539
      LIM3_Zyxin; The third LIM domain of Zyxin
      cl02475
      Location:320406
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl25764
      Location:170334
      PAT1; Topoisomerase II-associated protein PAT1

    Reference GRCh38.p12 PATCHES

    Genomic

    1. NW_018654714.1 Reference GRCh38.p12 PATCHES

      Range
      631..10475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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