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    VEZF1 vascular endothelial zinc finger 1 [ Homo sapiens (human) ]

    Gene ID: 7716, updated on 12-Aug-2018

    Summary

    Official Symbol
    VEZF1provided by HGNC
    Official Full Name
    vascular endothelial zinc finger 1provided by HGNC
    Primary source
    HGNC:HGNC:12949
    See related
    Ensembl:ENSG00000136451 MIM:606747; Vega:OTTHUMG00000178777
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DB1; ZNF161
    Summary
    Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein (Koyano-Nakagawa et al., 1994 [PubMed 8035792]). See MIM 603971 for general information on zinc finger proteins.[supplied by OMIM, Sep 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 19.6), endometrium (RPKM 18.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See VEZF1 in Genome Data Viewer
    Location:
    17q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (57971547..57988264, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (56048908..56065615, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S23 Neighboring gene CUE domain containing 1 Neighboring gene uncharacterized LOC107985065 Neighboring gene uncharacterized LOC101929185 Neighboring gene serine and arginine rich splicing factor 1 Neighboring gene uncharacterized LOC105371840

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    endothelial cell development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endothelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    vascular endothelial zinc finger 1
    Names
    putative transcription factor DB1
    zinc finger protein 161

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330393.1NP_001317322.1  vascular endothelial zinc finger 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC015813, BU729102
      Consensus CDS
      CCDS82169.1
      UniProtKB/TrEMBL
      J3QSH4
    2. NM_007146.2NP_009077.2  vascular endothelial zinc finger 1 isoform 1

      See identical proteins and their annotated locations for NP_009077.2

      Status: VALIDATED

      Source sequence(s)
      AA195154, BG718897, BX648862, D28118
      Consensus CDS
      CCDS32687.1
      UniProtKB/Swiss-Prot
      Q14119
      Related
      ENSP00000462337.1, OTTHUMP00000260036, ENST00000581208.1, OTTHUMT00000443321
      Conserved Domains (2) summary
      sd00017
      Location:176196
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:188213
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      57971547..57988264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257643.1XP_005257700.1  vascular endothelial zinc finger 1 isoform X1

      Conserved Domains (2) summary
      sd00017
      Location:176196
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:188213
      zf-H2C2_2; Zinc-finger double domain
    2. XM_005257644.5XP_005257701.1  vascular endothelial zinc finger 1 isoform X2

      See identical proteins and their annotated locations for XP_005257701.1

      Conserved Domains (2) summary
      sd00017
      Location:167187
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:179204
      zf-H2C2_2; Zinc-finger double domain
    3. XM_017025018.1XP_016880507.1  vascular endothelial zinc finger 1 isoform X3

      UniProtKB/TrEMBL
      J3QSH4
      Related
      ENSP00000464687.1, OTTHUMP00000260035, ENST00000584396.5, OTTHUMT00000443320
      Conserved Domains (2) summary
      sd00017
      Location:167187
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:179204
      zf-H2C2_2; Zinc-finger double domain
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