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    WNT1 Wnt family member 1 [ Homo sapiens (human) ]

    Gene ID: 7471, updated on 15-Apr-2018
    Official Symbol
    WNT1provided by HGNC
    Official Full Name
    Wnt family member 1provided by HGNC
    Primary source
    HGNC:HGNC:12774
    See related
    Ensembl:ENSG00000125084 MIM:164820; Vega:OTTHUMG00000170403
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INT1; OI15; BMND16
    Summary
    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    Location:
    12q13.12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (48978453..48982613)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49372236..49376396)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor 3 Neighboring gene Wnt family member 10B Neighboring gene RNA, U6 small nuclear 940, pseudogene Neighboring gene uncharacterized LOC105369757 Neighboring gene uncharacterized LOC105369756 Neighboring gene DDN and PRKAG1 antisense RNA 1 Neighboring gene dendrin

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of wingless-type MMTV integration site family, member 1 (WNT1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat-mediated downregulation of beta-catenin/Wnt signaling is dependent on the core and cysteine-rich domains (residues 20-48) of Tat PubMed

    Go to the HIV-1, Human Interaction Database

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    • Beta-catenin independent WNT signaling, organism-specific biosystem (from REACTOME)
      Beta-catenin independent WNT signaling, organism-specific biosystemHumans and mice have 19 identified WNT proteins that were originally classified as either 'canonical' or 'non-canonical' depending upon whether they were able to transform the mouse mammary epithelia...
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      Pathways in cancer, organism-specific biosystem
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      Wnt signaling network, organism-specific biosystem
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    frizzled binding IC
    Inferred by Curator
    more info
    PubMed 
    frizzled binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    morphogen activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    receptor ligand activity IC
    Inferred by Curator
    more info
    PubMed 
    receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor ligand activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Spemann organizer formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
     
    Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Wnt signaling pathway TAS
    Traceable Author Statement
    more info
     
    Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    Wnt signaling pathway, planar cell polarity pathway TAS
    Traceable Author Statement
    more info
     
    animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    astrocyte-dopaminergic neuron signaling IEA
    Inferred from Electronic Annotation
    more info
     
    beta-catenin destruction complex disassembly TAS
    Traceable Author Statement
    more info
     
    bone development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    canonical Wnt signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    canonical Wnt signaling pathway involved in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell proliferation in midbrain IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to peptide hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cerebellum formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    diencephalon development IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic axis specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    embryonic brain development IEA
    Inferred from Electronic Annotation
    more info
     
    forebrain anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    hepatocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    inner ear morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    midbrain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    midbrain-hindbrain boundary maturation during brain development IEA
    Inferred from Electronic Annotation
    more info
     
    myoblast fusion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell aging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of oxidative stress-induced neuron death IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neuron fate determination IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dermatome development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of insulin-like growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to wounding IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    signal transduction in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spinal cord association neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent SMAD protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi lumen TAS
    Traceable Author Statement
    more info
     
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    extracellular exosome TAS
    Traceable Author Statement
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    proto-oncogene Wnt-1
    Names
    proto-oncogene Int-1 homolog
    wingless-type MMTV integration site family member 1
    wingless-type MMTV integration site family, member 1 (oncogene INT1)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033141.1 RefSeqGene

      Range
      5001..9161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005430.3NP_005421.1  proto-oncogene Wnt-1 precursor

      See identical proteins and their annotated locations for NP_005421.1

      Status: REVIEWED

      Source sequence(s)
      AC073610, BC074798
      Consensus CDS
      CCDS8776.1
      UniProtKB/Swiss-Prot
      P04628
      Related
      ENSP00000293549.3, OTTHUMP00000243705, ENST00000293549.3, OTTHUMT00000408937
      Conserved Domains (1) summary
      smart00097
      Location:60370
      WNT1; found in Wnt-1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      48978453..48982613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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