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    VPREB1 V-set pre-B cell surrogate light chain 1 [ Homo sapiens (human) ]

    Gene ID: 7441, updated on 13-Feb-2019

    Summary

    Official Symbol
    VPREB1provided by HGNC
    Official Full Name
    V-set pre-B cell surrogate light chain 1provided by HGNC
    Primary source
    HGNC:HGNC:12709
    See related
    Ensembl:ENSG00000169575 IMGT/GENE-DB:VPREB1; MIM:605141
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IGI; IGVPB; VPREB; CD179a
    Summary
    The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
    Orthologs

    Genomic context

    See VPREB1 in Genome Data Viewer
    Location:
    22q11.22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (22244780..22245515)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (22599200..22599926)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene immunoglobulin lambda locus Neighboring gene URI1, prefoldin-like chaperone pseudogene Neighboring gene DNA topoisomerase III beta pseudogene 1 Neighboring gene uncharacterized LOC105372952 Neighboring gene BMS1 pseudogene 20 Neighboring gene immunoglobulin lambda variable 5-52

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immunoglobulin production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    immunoglobulin iota chain
    Names
    CD179 antigen-like family member A
    pre-B lymphocyte 1
    v(pre)B protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_000002.1 

      Range
      223181..223916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    2. NG_029387.2 RefSeqGene

      Range
      4991..5726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001303509.1NP_001290438.1  immunoglobulin iota chain isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC245060
      Consensus CDS
      CCDS77657.1
      UniProtKB/TrEMBL
      F8W8C9
      Related
      ENSP00000304590.2, ENST00000302273.2
      Conserved Domains (2) summary
      smart00410
      Location:25115
      IG_like; Immunoglobulin like
      cl11960
      Location:29117
      Ig; Immunoglobulin domain
    2. NM_007128.3NP_009059.1  immunoglobulin iota chain isoform 1 precursor

      See identical proteins and their annotated locations for NP_009059.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC245060, BC017922, BG502270
      Consensus CDS
      CCDS13798.1
      UniProtKB/Swiss-Prot
      P12018
      Related
      ENSP00000385361.3, ENST00000403807.3
      Conserved Domains (2) summary
      smart00410
      Location:26116
      IG_like; Immunoglobulin like
      cl11960
      Location:30118
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

      Range
      22244780..22245515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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