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    VASP vasodilator stimulated phosphoprotein [ Homo sapiens (human) ]

    Gene ID: 7408, updated on 22-Mar-2021

    Summary

    Official Symbol
    VASPprovided by HGNC
    Official Full Name
    vasodilator stimulated phosphoproteinprovided by HGNC
    Primary source
    HGNC:HGNC:12652
    See related
    Ensembl:ENSG00000125753 MIM:601703
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in appendix (RPKM 50.6), spleen (RPKM 48.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See VASP in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20210226 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45507459..45526989)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46010737..46030241)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene reticulon 2 Neighboring gene uncharacterized LOC107985314 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1N (putative) Neighboring gene uncharacterized LOC107985315 Neighboring gene outer mitochondrial membrane lipid metabolism regulator OPA3 Neighboring gene G protein-coupled receptor 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3 domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    cadherin binding HDA PubMed 
    profilin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    profilin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin polymerization or depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axon guidance TAS
    Traceable Author Statement
    more info
     
    cell junction assembly TAS
    Traceable Author Statement
    more info
     
    neural tube closure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    filopodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion HDA PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
     
    lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    vasodilator-stimulated phosphoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003370.4NP_003361.1  vasodilator-stimulated phosphoprotein

      See identical proteins and their annotated locations for NP_003361.1

      Status: REVIEWED

      Source sequence(s)
      BC038224, BG751094, Z46389
      Consensus CDS
      CCDS33051.1
      UniProtKB/Swiss-Prot
      P50552
      UniProtKB/TrEMBL
      A0A024R0V4
      Related
      ENSP00000245932.5, ENST00000245932.11
      Conserved Domains (2) summary
      cd01207
      Location:5113
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:342376
      VASP_tetra; VASP tetramerization domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      45507459..45526989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259200.2XP_005259257.1  vasodilator-stimulated phosphoprotein isoform X2

      Conserved Domains (2) summary
      cd01207
      Location:5113
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:341375
      VASP_tetra; VASP tetramerization domain
    2. XM_005259199.2XP_005259256.1  vasodilator-stimulated phosphoprotein isoform X1

      See identical proteins and their annotated locations for XP_005259256.1

      Conserved Domains (2) summary
      cd01207
      Location:5113
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:341375
      VASP_tetra; VASP tetramerization domain
    3. XM_017027200.2XP_016882689.1  vasodilator-stimulated phosphoprotein isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001008736.1: Suppressed sequence

      Description
      NM_001008736.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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