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    TNFRSF4 TNF receptor superfamily member 4 [ Homo sapiens (human) ]

    Gene ID: 7293, updated on 6-Jan-2019

    Summary

    Official Symbol
    TNFRSF4provided by HGNC
    Official Full Name
    TNF receptor superfamily member 4provided by HGNC
    Primary source
    HGNC:HGNC:11918
    See related
    Ensembl:ENSG00000186827 MIM:600315
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OX40; ACT35; CD134; IMD16; TXGP1L
    Summary
    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 2.7), lymph node (RPKM 1.6) and 14 other tissues See more
    Orthologs

    Genomic context

    See TNFRSF4 in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (1211326..1216812, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1146706..1149703, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TTLL10 antisense RNA 1 Neighboring gene tubulin tyrosine ligase like 10 Neighboring gene TNF receptor superfamily member 18 Neighboring gene stromal cell derived factor 4 Neighboring gene beta-1,3-galactosyltransferase 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Immunodeficiency 16
    MedGen: C3810053 OMIM: 615593 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of tumor necrosis factor receptor superfamily, member 4 (TNFRSF4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Downstream signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      Downstream signaling in naive CD8+ T cells, organism-specific biosystem
      Downstream signaling in naive CD8+ T cells
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • TNFR2 non-canonical NF-kB pathway, organism-specific biosystem (from REACTOME)
      TNFR2 non-canonical NF-kB pathway, organism-specific biosystemTumor necrosis factor-alpha (TNFA) exerts a wide range of biological effects through TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Under normal physiological conditions TNFR2 exhibits more restr...
    • TNFs bind their physiological receptors, organism-specific biosystem (from REACTOME)
      TNFs bind their physiological receptors, organism-specific biosystemMembers of the tumour necrosis factor superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity. These members are implicated in various acquir...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tumor necrosis factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of activation-induced cell death of T cells IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cytokine secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of B cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of B cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of immunoglobulin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of immunoglobulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tumor necrosis factor-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor receptor superfamily member 4
    Names
    ACT35 antigen
    ATC35 antigen
    CD134 antigen
    OX40 antigen
    OX40 cell surface antigen
    OX40 homologue
    OX40L receptor
    TAX transcriptionally-activated glycoprotein 1 receptor
    lymphoid activation antigene ACT35
    tax-transcriptionally activated glycoprotein 1 receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046896.1 RefSeqGene

      Range
      5486..8299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003327.4NP_003318.1  tumor necrosis factor receptor superfamily member 4 precursor

      See identical proteins and their annotated locations for NP_003318.1

      Status: REVIEWED

      Source sequence(s)
      BC105070
      Consensus CDS
      CCDS11.1
      UniProtKB/Swiss-Prot
      P43489
      Related
      ENSP00000368538.3, ENST00000379236.3
      Conserved Domains (1) summary
      cd13406
      Location:29170
      TNFRSF4; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      1211326..1216812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002232.1XP_016857721.1  tumor necrosis factor receptor superfamily member 4 isoform X4

      UniProtKB/Swiss-Prot
      P43489
      Conserved Domains (1) summary
      cd13406
      Location:29170
      TNFRSF4; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40
    2. XM_011542076.2XP_011540378.1  tumor necrosis factor receptor superfamily member 4 isoform X3

      Conserved Domains (1) summary
      cl22855
      Location:95174
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    3. XM_017002231.1XP_016857720.1  tumor necrosis factor receptor superfamily member 4 isoform X2

      Conserved Domains (1) summary
      cd13406
      Location:29170
      TNFRSF4; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40
    4. XM_011542075.2XP_011540377.1  tumor necrosis factor receptor superfamily member 4 isoform X2

      Conserved Domains (1) summary
      cd13406
      Location:29170
      TNFRSF4; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40
    5. XM_011542074.2XP_011540376.1  tumor necrosis factor receptor superfamily member 4 isoform X1

      See identical proteins and their annotated locations for XP_011540376.1

      Conserved Domains (1) summary
      cl22855
      Location:95174
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    6. XM_011542077.2XP_011540379.1  tumor necrosis factor receptor superfamily member 4 isoform X5

      Conserved Domains (1) summary
      cl22855
      Location:2470
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
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