Adipor1 adiponectin receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adipor1provided by MGI
Official Full Name: adiponectin receptor 1provided by MGI
Primary source: MGI:MGI:1919924
See related: Ensembl:ENSMUSG00000026457
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Paqr1; ACDCR1; CGI-45; 2810031L11Rik
Summary: This gene encodes a receptor for the fat-derived hormone adiponectin. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. Homozygous knockout mice for this gene exhibit elevated plasma glucose and insulin levels as well as impaired glucose tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression: Ubiquitous expression in adrenal adult (RPKM 87.2), colon adult (RPKM 63.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1; 1 E4

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (134343116..134361089)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (134415378..134433351)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	1	NC_000067.5 (136312044..136328918)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of Adiponectin Receptor 1 Inhibits Brown and Beige Adipose Tissue Activity in Mice.
Title: Overexpression of Adiponectin Receptor 1 Inhibits Brown and Beige Adipose Tissue Activity in Mice.
Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1alpha-Dependent Glycolysis.
Title: Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1α-Dependent Glycolysis.
GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension.
Title: GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension.
Lung Regulatory T Cells Express Adiponectin Receptor 1: Modulation by Obesity and Airway Allergic Inflammation.
Title: Lung Regulatory T Cells Express Adiponectin Receptor 1: Modulation by Obesity and Airway Allergic Inflammation.
Adiponectin promotes myogenic differentiation via a Mef2C-AdipoR1 positive feedback loop.
Title: Adiponectin promotes myogenic differentiation via a Mef2C-AdipoR1 positive feedback loop.
Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer's Like Pathology in Mice Brain.
Title: Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer's Like Pathology in Mice Brain.
both MFRP and AdipoR1 proteins are necessary for retinal lipidome membrane organization, visual function, and to the understanding of the early pathology of retinal degenerative diseases
Title: Membrane-type frizzled-related protein regulates lipidome and transcription for photoreceptor function.
a role for ADIPOR1 in retinoid metabolism
Title: ADIPOR1 is essential for vision and its RPE expression is lost in the Mfrp<sup>rd6</sup> mouse.
AdipoR1 knockdown mice exhibited increased body weight and abnormal plasma chemistry, and also showed spatial learning and memory impairment in behavioral studies.
Title: Suppression of adiponectin receptor 1 promotes memory dysfunction and Alzheimer's disease-like pathologies.
ADIPOR activation restores AMPK (AMP-activated protein kinase)-mediated autophagosome formation and antioxidant-mediated autophagosome clearance, representing a novel intervention effective against myocardial ischemia-reperfusion injury in diabetic conditions.
Title: Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling.

Submit: New GeneRIF Correction See all GeneRIFs (74)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (9) 1 citation

General gene information

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Markers

Adipor1 (e-PCR), detects polymorphism
- UniSTS:471066

Adipor1 (e-PCR), detects polymorphism
- UniSTS:495948

RH16184 (e-PCR)
- UniSTS:46496

Homology

Homologs of the Adipor1 gene: The Adipor1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, rice, and frog.
Orthologs from Annotation Pipeline: 276 organisms have orthologs with human gene Adipor1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adipokinetic hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables adiponectin binding	IPI Inferred from Physical Interaction more info	PubMed
enables adiponectin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adiponectin-activated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within adiponectin-activated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adiponectin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adiponectin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid oxidation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in leptin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of NIK/NF-kappaB signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in integral component of membrane	IEA Inferred from Electronic Annotation more info
located_in intrinsic component of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adiponectin receptor protein 1

Names: progestin and adipoQ receptor family member 1; progestin and adipoQ receptor family member I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001306069.1 → NP_001292998.1 adiponectin receptor protein 1

See identical proteins and their annotated locations for NP_001292998.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC131592, AK143680, AW047193, AY424290, CK623806

Consensus CDS

CCDS15309.1

UniProtKB/Swiss-Prot

Q91VH1

UniProtKB/TrEMBL

Q3UPA4, Q53YY4

Related

ENSMUSP00000107856.2, ENSMUST00000112237.2

Conserved Domains (1) summary

pfam03006
Location:129 → 352

HlyIII; Haemolysin-III related
NM_028320.4 → NP_082596.2 adiponectin receptor protein 1

See identical proteins and their annotated locations for NP_082596.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC131592, AK143680, AW047193, AY424290, CA945374

Consensus CDS

CCDS15309.1

UniProtKB/Swiss-Prot

Q91VH1

UniProtKB/TrEMBL

Q3UPA4, Q53YY4

Related

ENSMUSP00000027727.9, ENSMUST00000027727.15

Conserved Domains (1) summary

pfam03006
Location:129 → 352

HlyIII; Haemolysin-III related