Adipor1 adiponectin receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adipor1provided by MGI
Official Full Name: adiponectin receptor 1provided by MGI
Primary source: MGI:MGI:1919924
See related: Ensembl:ENSMUSG00000026457 AllianceGenome:MGI:1919924
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Paqr1; ACDCR1; CGI-45; 2810031L11Rik
Summary: This gene encodes a receptor for the fat-derived hormone adiponectin. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. Homozygous knockout mice for this gene exhibit elevated plasma glucose and insulin levels as well as impaired glucose tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression: Ubiquitous expression in adrenal adult (RPKM 87.2), colon adult (RPKM 63.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 58.22 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (134343116..134361089)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (134415378..134433351)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Running exercise alleviates hippocampal neuroinflammation and shifts the balance of microglial M1/M2 polarization through adiponectin/AdipoR1 pathway activation in mice exposed to chronic unpredictable stress.
Title: Running exercise alleviates hippocampal neuroinflammation and shifts the balance of microglial M1/M2 polarization through adiponectin/AdipoR1 pathway activation in mice exposed to chronic unpredictable stress.
Decreased AdipoR1 signaling and its implications for obesity-induced male infertility.
Title: Decreased AdipoR1 signaling and its implications for obesity-induced male infertility.
Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice.
Title: Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice.
Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure.
Title: Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure.
Estradiol overcomes adiponectin-resistance in diabetic mice by regulating skeletal muscle adiponectin receptor 1 expression.
Title: Estradiol overcomes adiponectin-resistance in diabetic mice by regulating skeletal muscle adiponectin receptor 1 expression.
Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision.
Title: Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision.
Genetic Interaction between Mfrp and Adipor1 Mutations Affect Retinal Disease Phenotypes.
Title: Genetic Interaction between Mfrp and Adipor1 Mutations Affect Retinal Disease Phenotypes.
Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons.
Title: Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons.
Adiponectin inhibits Dgalinduced cardiomyocyte senescence via AdipoR1/APPL1.
Title: Adiponectin inhibits D‑gal‑induced cardiomyocyte senescence via AdipoR1/APPL1.
ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss.
Title: ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss.

Submit: New GeneRIF Correction See all GeneRIFs (85)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Gene trapped (1)
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adipor1 (e-PCR), detects polymorphism
- UniSTS:471066

Adipor1 (e-PCR), detects polymorphism
- UniSTS:495948

RH16184 (e-PCR)
- UniSTS:46496

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adipokinetic hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables adipokinetic hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables adipokinetic hormone receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables adiponectin binding	IEA Inferred from Electronic Annotation more info
enables adiponectin binding	IPI Inferred from Physical Interaction more info	PubMed
enables adiponectin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adiponectin-activated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adiponectin-activated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adiponectin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adiponectin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adiponectin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid oxidation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in leptin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in leptin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: adiponectin receptor protein 1

Names: progestin and adipoQ receptor family member 1; progestin and adipoQ receptor family member I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001306069.1 → NP_001292998.1 adiponectin receptor protein 1

See identical proteins and their annotated locations for NP_001292998.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC131592, AK143680, AW047193, AY424290, CK623806

Consensus CDS

CCDS15309.1

UniProtKB/Swiss-Prot

Q91VH1, Q9CZA0

UniProtKB/TrEMBL

Q3TI02, Q3UPA4, Q53YY4

Related

ENSMUSP00000107856.2, ENSMUST00000112237.2

Conserved Domains (1) summary

pfam03006
Location:129 → 352

HlyIII; Haemolysin-III related
NM_028320.4 → NP_082596.2 adiponectin receptor protein 1

See identical proteins and their annotated locations for NP_082596.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC131592, AK143680, AW047193, AY424290, CA945374

Consensus CDS

CCDS15309.1

UniProtKB/Swiss-Prot

Q91VH1, Q9CZA0

UniProtKB/TrEMBL

Q3TI02, Q3UPA4, Q53YY4

Related

ENSMUSP00000027727.9, ENSMUST00000027727.15

Conserved Domains (1) summary

pfam03006
Location:129 → 352

HlyIII; Haemolysin-III related