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    Adipor1 adiponectin receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 72674, updated on 8-Dec-2018

    Summary

    Official Symbol
    Adipor1provided by MGI
    Official Full Name
    adiponectin receptor 1provided by MGI
    Primary source
    MGI:MGI:1919924
    See related
    Ensembl:ENSMUSG00000026457
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Paqr1; ACDCR1; CGI-45; 2810031L11Rik
    Summary
    This gene encodes a receptor for the fat-derived hormone adiponectin. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. Homozygous knockout mice for this gene exhibit elevated plasma glucose and insulin levels as well as impaired glucose tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 87.2), colon adult (RPKM 63.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Adipor1 in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (134415378..134433351)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (136312044..136328918)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933406M09 gene Neighboring gene cytochrome b5 reductase 1 Neighboring gene kelch-like 12 Neighboring gene RAB interacting factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    adipokinetic hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    adiponectin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    adiponectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    adiponectin-activated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adiponectin-activated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adiponectin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adiponectin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hormone-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    hormone-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    leptin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    adiponectin receptor protein 1
    Names
    progestin and adipoQ receptor family member 1
    progestin and adipoQ receptor family member I

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306069.1NP_001292998.1  adiponectin receptor protein 1

      See identical proteins and their annotated locations for NP_001292998.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC131592, AK143680, AW047193, AY424290, CK623806
      Consensus CDS
      CCDS15309.1
      UniProtKB/Swiss-Prot
      Q91VH1
      UniProtKB/TrEMBL
      Q3UPA4, Q53YY4
      Related
      ENSMUSP00000107856.1, ENSMUST00000112237.1
      Conserved Domains (1) summary
      pfam03006
      Location:129352
      HlyIII; Haemolysin-III related
    2. NM_028320.4NP_082596.2  adiponectin receptor protein 1

      See identical proteins and their annotated locations for NP_082596.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC131592, AK143680, AW047193, AY424290, CA945374
      Consensus CDS
      CCDS15309.1
      UniProtKB/Swiss-Prot
      Q91VH1
      UniProtKB/TrEMBL
      Q3UPA4, Q53YY4
      Related
      ENSMUSP00000027727.8, ENSMUST00000027727.14
      Conserved Domains (1) summary
      pfam03006
      Location:129352
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      134415378..134433351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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