Adipor1 adiponectin receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adipor1provided by MGI
Official Full Name: adiponectin receptor 1provided by MGI
Primary source: MGI:MGI:1919924
See related: Ensembl:ENSMUSG00000026457
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Paqr1; ACDCR1; CGI-45; 2810031L11Rik
Summary: This gene encodes a receptor for the fat-derived hormone adiponectin. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. Homozygous knockout mice for this gene exhibit elevated plasma glucose and insulin levels as well as impaired glucose tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression: Ubiquitous expression in adrenal adult (RPKM 87.2), colon adult (RPKM 63.6) and 28 other tissues See more
Orthologs: human all

Genomic context

Location:: 1; 1 E4

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCm38.p4 (GCF_000001635.24)	1	NC_000067.6 (134415378..134433351)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	1	NC_000067.5 (136312044..136328918)

Chromosome 1 - NC_000067.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

ADIPOR activation restores AMPK (AMP-activated protein kinase)-mediated autophagosome formation and antioxidant-mediated autophagosome clearance, representing a novel intervention effective against myocardial ischemia-reperfusion injury in diabetic conditions.
Title: Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling.
these results demonstrate that AdipoR1 and AdipoR2 exhibit overlapping and distinct effects in skeletal muscle consistent with enhanced adiponectin sensitivity but these appear insufficient to ameliorate established obesity-induced adiponectin resistance.
Title: Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects.
miR-323-3p appears to be a crucial diabetes factor that mediates its functions by inhibiting the AdipoR1/AMPK/SIRT-1 signaling pathway.
Title: Adiponectin receptor 1-mediated micro RNA-323-3p regulates functions of the MIN6 cell line via the AMP-activated protein kinase/sirtuin-1 pathway.
although the physiological levels of adiponectin are sufficient to activate AMPK and Akt when AdipoR1 is overexpressed in beta-cells, yet adiponectin cannot protect beta-cells in Akita mice from ER stress-induced destruction
Title: β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice.
Immunofluorescence indicated that GPRC6A and adiponectin receptor 1 were co-localized in mouse muscle tissues. The present finding suggested adiponectin receptor 1 can mediate the improvement of glucose metabolism by osteocalcin in ovariectomized mice
Title: Adiponectin receptor 1 resists the decline of serum osteocalcin and GPRC6A expression in ovariectomized mice.
adiponectin maintains intestinal homeostasis and protects against murine colitis through interactions with its receptor AdipoR1 and by modulating adaptive immunity and STAT3 signaling
Title: Adiponectin confers protection from acute colitis and restricts a B cell immune response.
Based on these findings, this study showed that CTRP9 might induce mitochondrial biogenesis and protect high glucose-induced endothelial oxidative damage via AdipoR1-SIRT1-PGC-1alpha signaling pathway.
Title: CTRP9 induces mitochondrial biogenesis and protects high glucose-induced endothelial oxidative damage via AdipoR1 -SIRT1- PGC-1α activation.
High salt is an important suppressor of cardioprotective APN and AdipoR1 in cardiac myocytes.
Title: Regulation of the cardioprotective adiponectin and its receptor AdipoR1 by salt.
AdipoR1, not AdipoR2, was first identified as a receptor of CTRP6 during the process of mitotic clonal expansion. Collectively, we suggest that CTRP6 mediates the ectopic lipogenesis through AdipoR1/Erk/PPARgamma signaling pathway in myoblasts.
Title: Lipogenesis in myoblasts and its regulation of CTRP6 by AdipoR1/Erk/PPARγ signaling pathway.
The results demonstrated a dynamic dysfunction of APN/AdipoR1 axis accompanying progression of diabetes mellitus in mice with cerebral ischemia.
Title: Therapeutic window of globular adiponectin against cerebral ischemia in diabetic mice: the role of dynamic alteration of adiponectin/adiponectin receptor expression.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (8) 1 citation

Pathways from BioSystems

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AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem (from REACTOME)
AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystemcomputationally inferred pathway (not manually curated)
AMPK signaling pathway, organism-specific biosystem (from KEGG)
AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
AMPK signaling pathway, conserved biosystem (from KEGG)
AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
Adipocytokine signaling pathway, conserved biosystem (from KEGG)
Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
Integration of energy metabolism, organism-specific biosystem (from REACTOME)
Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Leptin and adiponectin, organism-specific biosystem (from WikiPathways)
Leptin and adiponectin, organism-specific biosystemProposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in [http://www.ncbi.nlm.nih.gov/pubmed/16497175 Dyck et al.].
Longevity regulating pathway, organism-specific biosystem (from KEGG)
Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

General gene information

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Markers

Adipor1 (e-PCR), detects polymorphism
- UniSTS:471066

Adipor1 (e-PCR), detects polymorphism
- UniSTS:495948

RH16184 (e-PCR)
- UniSTS:46496

Homology

Homologs of the Adipor1 gene: The Adipor1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, rice, and frog.
Orthologs from Annotation Pipeline: 249 organisms have orthologs with human gene Adipor1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
adipokinetic hormone receptor activity	ISO Inferred from Sequence Orthology more info
adiponectin binding	IPI Inferred from Physical Interaction more info	PubMed
adiponectin binding	ISO Inferred from Sequence Orthology more info
identical protein binding	IDA Inferred from Direct Assay more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	ISO Inferred from Sequence Orthology more info
signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
adiponectin-activated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
adiponectin-activated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
adiponectin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
adiponectin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
fatty acid oxidation	ISO Inferred from Sequence Orthology more info
fatty acid oxidation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
hormone-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
leptin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
lipid metabolic process	IEA Inferred from Electronic Annotation more info
negative regulation of JAK-STAT cascade	ISO Inferred from Sequence Orthology more info
negative regulation of NIK/NF-kappaB signaling	ISO Inferred from Sequence Orthology more info
negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
positive regulation of JAK-STAT cascade	ISO Inferred from Sequence Orthology more info
positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
regulation of glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
integral component of membrane	IEA Inferred from Electronic Annotation more info
intrinsic component of plasma membrane	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adiponectin receptor protein 1

Names: progestin and adipoQ receptor family member 1; progestin and adipoQ receptor family member I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001306069.1 → NP_001292998.1 adiponectin receptor protein 1

See identical proteins and their annotated locations for NP_001292998.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC131592, AK143680, AW047193, AY424290, CK623806

Consensus CDS

CCDS15309.1

UniProtKB/Swiss-Prot

Q91VH1

UniProtKB/TrEMBL

Q3UPA4, Q53YY4

Related

ENSMUSP00000107856.1, ENSMUST00000112237.1

Conserved Domains (1) summary

pfam03006
Location:129 → 352

HlyIII; Haemolysin-III related
NM_028320.4 → NP_082596.2 adiponectin receptor protein 1

See identical proteins and their annotated locations for NP_082596.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC131592, AK143680, AW047193, AY424290, CA945374

Consensus CDS

CCDS15309.1

UniProtKB/Swiss-Prot

Q91VH1

UniProtKB/TrEMBL

Q3UPA4, Q53YY4

Related

ENSMUSP00000027727.8, ENSMUST00000027727.14

Conserved Domains (1) summary

pfam03006
Location:129 → 352

HlyIII; Haemolysin-III related