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    TPT1 tumor protein, translationally-controlled 1 [ Homo sapiens (human) ]

    Gene ID: 7178, updated on 17-Jun-2019

    Summary

    Official Symbol
    TPT1provided by HGNC
    Official Full Name
    tumor protein, translationally-controlled 1provided by HGNC
    Primary source
    HGNC:HGNC:12022
    See related
    Ensembl:ENSG00000133112 MIM:600763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HRF; p02; p23; TCTP
    Summary
    This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
    Expression
    Ubiquitous expression in ovary (RPKM 496.6), thyroid (RPKM 416.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See TPT1 in Genome Data Viewer
    Location:
    13q14.13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (45333471..45341284, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (45911005..45915505, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene general transcription factor IIF subunit 2 Neighboring gene potassium channel tetramerization domain containing 4 Neighboring gene uncharacterized LOC105370190 Neighboring gene small nucleolar RNA, H/ACA box 31B Neighboring gene small nucleolar RNA, H/ACA box 31 Neighboring gene TPT1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 12652 Neighboring gene reticulocalbin 1 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of tumor protein, translationally-controlled 1 (TPT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ27337

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    extracellular exosome HDA PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    multivesicular body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    translationally-controlled tumor protein
    Names
    fortilin
    histamine-releasing factor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286272.1NP_001273201.1  translationally-controlled tumor protein isoform 1

      See identical proteins and their annotated locations for NP_001273201.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL138963
      Consensus CDS
      CCDS73566.1
      UniProtKB/TrEMBL
      A0A0B4J2C3
      Related
      ENSP00000477781.1, ENST00000616577.4
      Conserved Domains (1) summary
      pfam00838
      Location:1167
      TCTP; Translationally controlled tumor protein
    2. NM_001286273.2NP_001273202.1  translationally-controlled tumor protein isoform 3

      See identical proteins and their annotated locations for NP_001273202.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains multiple differences in the coding region, compared to variant 1, including initiation of translation at a downstream in-frame start codon. The encoded isoform (3) has shorter N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AL138963, BC022436
      Consensus CDS
      CCDS66538.1
      UniProtKB/Swiss-Prot
      P13693
      UniProtKB/TrEMBL
      A0A024RDY2
      Related
      ENSP00000368345.1, ENST00000379056.5
      Conserved Domains (1) summary
      pfam00838
      Location:1133
      TCTP; Translationally controlled tumor protein
    3. NM_003295.4NP_003286.1  translationally-controlled tumor protein isoform 2

      See identical proteins and their annotated locations for NP_003286.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter C-terminus than isoform 1.
      Source sequence(s)
      AL138963, BP215975, X16064
      Consensus CDS
      CCDS9397.1
      UniProtKB/Swiss-Prot
      P13693
      UniProtKB/TrEMBL
      A0A0P1J1R0
      Related
      ENSP00000431872.1, ENST00000530705.5
      Conserved Domains (1) summary
      pfam00838
      Location:1167
      TCTP; Translationally controlled tumor protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      45333471..45341284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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