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    TMSB4X thymosin beta 4 X-linked [ Homo sapiens (human) ]

    Gene ID: 7114, updated on 5-Aug-2018

    Summary

    Official Symbol
    TMSB4Xprovided by HGNC
    Official Full Name
    thymosin beta 4 X-linkedprovided by HGNC
    Primary source
    HGNC:HGNC:11881
    See related
    Ensembl:ENSG00000205542 MIM:300159; Vega:OTTHUMG00000021144
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FX; TB4X; PTMB4; TMSB4
    Summary
    This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 3301.5), lymph node (RPKM 3201.4) and 24 other tissues See more
    Orthologs

    Genomic context

    See TMSB4X in Genome Data Viewer
    Location:
    Xp22.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (12975107..12977227)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (12993226..12995346)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene toll like receptor 7 Neighboring gene TLR8 antisense RNA 1 Neighboring gene toll like receptor 8 Neighboring gene uncharacterized LOC105373133 Neighboring gene family with sequence similarity 9 member C Neighboring gene uncharacterized LOC105373134

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    actin monomer binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin monomer binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic sequestering of NF-kappaB IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of NIK/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-8 secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of ATP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of blood vessel endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of blood vessel endothelial cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of endothelial cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of proton-transporting ATP synthase activity, rotational mechanism IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of NIK/NF-kappaB signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sequestering of actin monomers IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sequestering of actin monomers IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region HDA PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    thymosin beta-4
    Names
    prothymosin beta-4
    t beta-4
    thymosin, beta 4, X chromosome

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021109.3NP_066932.1  thymosin beta-4

      See identical proteins and their annotated locations for NP_066932.1

      Status: REVIEWED

      Source sequence(s)
      AV715954, BC001631
      Consensus CDS
      CCDS35202.1
      UniProtKB/Swiss-Prot
      P62328
      UniProtKB/TrEMBL
      A2VCK8, Q0P5T0
      Related
      ENSP00000414376.2, OTTHUMP00000022926, ENST00000451311.6, OTTHUMT00000055780
      Conserved Domains (1) summary
      pfam01290
      Location:341
      Thymosin; Thymosin beta-4 family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

      Range
      12975107..12977227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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