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    TLR5 toll like receptor 5 [ Homo sapiens (human) ]

    Gene ID: 7100, updated on 16-Sep-2018

    Summary

    Official Symbol
    TLR5provided by HGNC
    Official Full Name
    toll like receptor 5provided by HGNC
    Primary source
    HGNC:HGNC:11851
    See related
    Ensembl:ENSG00000187554 MIM:603031; Vega:OTTHUMG00000037937
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLE1; TIL3; SLEB1; MELIOS
    Summary
    This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
    Expression
    Ubiquitous expression in ovary (RPKM 7.6), lung (RPKM 2.6) and 22 other tissues See more
    Orthologs

    Genomic context

    See TLR5 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (223108401..223143282, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (223282748..223316624, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724046 Neighboring gene uncharacterized LOC107985323 Neighboring gene sushi domain containing 4 Neighboring gene uncharacterized LOC105373025 Neighboring gene RNA, U4 small nuclear 57, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of toll-like receptor 5 (TLR5) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases associated with the TLR signaling cascade, organism-specific biosystem (from REACTOME)
      Diseases associated with the TLR signaling cascade, organism-specific biosystemToll like receptors (TLRs) are sensors of the innate immune system that detect danger signals derived from pathogens (pathogen-associated molecular patterns - PAMP) or damaged cells (damage-associate...
    • Diseases of Immune System, organism-specific biosystem (from REACTOME)
      Diseases of Immune System, organism-specific biosystemThe immune system is a complex network of the biological processes that provide defense mechanisms during infection or in response to an intrinsic danger signal. Compromised immune response may prese...
    • IRAK4 deficiency (TLR5), organism-specific biosystem (from REACTOME)
      IRAK4 deficiency (TLR5), organism-specific biosystemToll like receptor 5 (TLR5) specifically recognizes bacterial infection through binding of flagellin from pathogenic bacteria. Upon ligand binding, TLR5 dimers recruit MyD88 through their TIR domains...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
      Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
      Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
    • MyD88 deficiency (TLR5), organism-specific biosystem (from REACTOME)
      MyD88 deficiency (TLR5), organism-specific biosystemMyeloid differentiation primary response (MyD88) is an adaptor protein that mediates intracellular signaling pathways evoked by all Toll-like receptors (TLRs) (except for TLR3) and several interleuki...
    • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
      Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
      Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathogenic Escherichia coli infection, organism-specific biosystem (from WikiPathways)
      Pathogenic Escherichia coli infection, organism-specific biosystemSources: [http://www.genome.jp/kegg/pathway/hsa/hsa05130.html KEGG]
    • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Regulation of toll-like receptor signaling pathway, organism-specific biosystem
      Regulation of toll-like receptor signaling pathway
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Simplified Depiction of MYD88 Distinct Input-Output Pathway, organism-specific biosystem (from WikiPathways)
      Simplified Depiction of MYD88 Distinct Input-Output Pathway, organism-specific biosystemThis pathway is based on figure 7 from Li et al. Formation of MyD88 dimer catalyzes formation of IRAK1/TRAF6 complex. UEV1A and Ubc13 ubiquinate TRAF6 which allow for the activation of NFKB and AP-1 ...
    • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
    • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
    • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
      Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • Toll-like Receptor Signaling, organism-specific biosystem (from WikiPathways)
      Toll-like Receptor Signaling, organism-specific biosystemThis pathway is based on the figure 1 of "Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study" (see bibliography). TLR and NFkB are important in inflamma...
    • Toll-like Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Toll-like Receptor Signaling Pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10052, MGC126430, MGC126431

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    interleukin-1 receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MyD88-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of toll-like receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cytokine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    toll-like receptor 5 signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    toll-like receptor 5
    Names
    systemic lupus erythematosus susceptibility 1
    toll/interleukin-1 receptor-like protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016244.1 RefSeqGene

      Range
      5001..38877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003268.5NP_003259.2  toll-like receptor 5 precursor

      See identical proteins and their annotated locations for NP_003259.2

      Status: REVIEWED

      Source sequence(s)
      AB060695, AB445645, AL929091, BQ025528, DB448079
      Consensus CDS
      CCDS31033.1
      UniProtKB/Swiss-Prot
      O60602
      Related
      ENSP00000496355.1, OTTHUMP00000036039, ENST00000642603.1, OTTHUMT00000092596
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      223108401..223143282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711505.3XP_006711568.1  toll-like receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_006711568.1

      UniProtKB/Swiss-Prot
      O60602
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    2. XM_006711504.3XP_006711567.1  toll-like receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_006711567.1

      UniProtKB/Swiss-Prot
      O60602
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    3. XM_017002208.1XP_016857697.1  toll-like receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      O60602
      Related
      ENSP00000493892.1, ENST00000645434.1
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    4. XM_011509937.2XP_011508239.1  toll-like receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_011508239.1

      UniProtKB/Swiss-Prot
      O60602
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    5. XM_006711506.3XP_006711569.1  toll-like receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_006711569.1

      UniProtKB/Swiss-Prot
      O60602
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    6. XM_005273242.4XP_005273299.2  toll-like receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_005273299.2

      UniProtKB/Swiss-Prot
      O60602
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    7. XM_005273243.4XP_005273300.2  toll-like receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_005273300.2

      UniProtKB/Swiss-Prot
      O60602
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    8. XM_005273241.4XP_005273298.2  toll-like receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_005273298.2

      UniProtKB/Swiss-Prot
      O60602
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
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