U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    TK1 thymidine kinase 1 [ Homo sapiens (human) ]

    Gene ID: 7083, updated on 5-Mar-2024

    Summary

    Official Symbol
    TK1provided by HGNC
    Official Full Name
    thymidine kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:11830
    See related
    Ensembl:ENSG00000167900 MIM:188300; AllianceGenome:HGNC:11830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TK2
    Summary
    The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016]
    Expression
    Broad expression in bone marrow (RPKM 21.7), lymph node (RPKM 12.6) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TK1 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (78174079..78187204, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79068173..79081298, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76170160..76183285, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromosome 17 open reading frame 99 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76154005-76154506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9049 Neighboring gene eukaryotic translation initiation factor 5A pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76160142-76160642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12875 Neighboring gene synaptogyrin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12877 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76171843-76172621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76172622-76173399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76180346-76181247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9052 Neighboring gene arylformamidase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12879 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:76207979-76208182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76210079-76210980 Neighboring gene baculoviral IAP repeat containing 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates TK1 in HeLa cells within 12 hours of exposure PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thymidine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thymidine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    thymidine kinase, cytosolic
    Names
    cytosolic thymidine kinase
    epididymis secretory sperm binding protein
    NP_001333592.1
    NP_001350777.1
    NP_003249.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051962.1 RefSeqGene

      Range
      5153..18114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001346663.2NP_001333592.1  thymidine kinase, cytosolic isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC021593, AC087645
      Consensus CDS
      CCDS86643.1
      UniProtKB/TrEMBL
      K7ERJ1, K7ES52
      Related
      ENSP00000468556.1, ENST00000590862.5
      Conserved Domains (1) summary
      cl23762
      Location:18174
      TK; Thymidine kinase
    2. NM_001363848.1NP_001350777.1  thymidine kinase, cytosolic isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC021593, AC087645
      Consensus CDS
      CCDS86642.1
      UniProtKB/TrEMBL
      B5BU32, B5BUF9, K7ERV3
      Related
      ENSP00000468425.1, ENST00000588734.5
      Conserved Domains (1) summary
      cl23762
      Location:18225
      TK; Thymidine kinase
    3. NM_003258.5NP_003249.3  thymidine kinase, cytosolic isoform 1

      See identical proteins and their annotated locations for NP_003249.3

      Status: REVIEWED

      Source sequence(s)
      BC006484, BI754079
      Consensus CDS
      CCDS11754.1
      UniProtKB/Swiss-Prot
      B2RC58, P04183, Q969V0, Q9UMG9
      UniProtKB/TrEMBL
      A0A384MDV9, B5BU32, B5BUF9
      Related
      ENSP00000301634.6, ENST00000301634.12
      Conserved Domains (1) summary
      cl23762
      Location:18192
      TK; Thymidine kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      78174079..78187204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      79068173..79081298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)