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    TK1 thymidine kinase 1 [ Homo sapiens (human) ]

    Gene ID: 7083, updated on 28-Oct-2018

    Summary

    Official Symbol
    TK1provided by HGNC
    Official Full Name
    thymidine kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:11830
    See related
    Ensembl:ENSG00000167900 MIM:188300; Vega:OTTHUMG00000150674
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TK2
    Summary
    The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016]
    Expression
    Broad expression in bone marrow (RPKM 21.7), lymph node (RPKM 12.6) and 18 other tissues See more
    Orthologs

    Genomic context

    See TK1 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (78174079..78187204, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76170160..76183285, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromosome 17 open reading frame 99 Neighboring gene eukaryotic translation initiation factor 5A pseudogene 2 Neighboring gene uncharacterized LOC107985050 Neighboring gene synaptogyrin 2 Neighboring gene arylformamidase Neighboring gene baculoviral IAP repeat containing 5 Neighboring gene transmembrane protein 235

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates TK1 in HeLa cells within 12 hours of exposure PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nucleoside kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thymidine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    DNA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    deoxyribonucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    nucleobase-containing compound metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein homotetramerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    pyrimidine nucleoside salvage TAS
    Traceable Author Statement
    more info
     
    thymidine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    thymidine kinase, cytosolic
    Names
    epididymis secretory sperm binding protein
    thymidine kinase 1 soluble isoform
    NP_001333592.1
    NP_003249.3
    XP_016880481.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051962.1 RefSeqGene

      Range
      5001..18126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001346663.1NP_001333592.1  thymidine kinase, cytosolic isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC021593, AC087645
      Consensus CDS
      CCDS86643.1
      UniProtKB/TrEMBL
      K7ES52
      Related
      ENSP00000468556.1, ENST00000590862.5
      Conserved Domains (1) summary
      cl23762
      Location:18174
      TK; Thymidine kinase
    2. NM_001363848.1NP_001350777.1  thymidine kinase, cytosolic isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC021593, AC087645
      Consensus CDS
      CCDS86642.1
      Conserved Domains (1) summary
      cl23762
      Location:18225
      TK; Thymidine kinase
    3. NM_003258.4NP_003249.3  thymidine kinase, cytosolic isoform 1

      See identical proteins and their annotated locations for NP_003249.3

      Status: REVIEWED

      Source sequence(s)
      AA633286, BC006484, BI754079
      Consensus CDS
      CCDS11754.1
      UniProtKB/Swiss-Prot
      P04183
      Related
      ENSP00000301634.6, OTTHUMP00000198229, ENST00000301634.11, OTTHUMT00000319577
      Conserved Domains (1) summary
      cl23762
      Location:18192
      TK; Thymidine kinase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      78174079..78187204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024992.2XP_016880481.2  thymidine kinase, cytosolic isoform X1

      Related
      ENSP00000468425.1, ENST00000588734.5
      Conserved Domains (1) summary
      cl23762
      Location:18225
      TK; Thymidine kinase
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