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    TIAM1 TIAM Rac1 associated GEF 1 [ Homo sapiens (human) ]

    Gene ID: 7074, updated on 28-Nov-2021

    Summary

    Official Symbol
    TIAM1provided by HGNC
    Official Full Name
    TIAM Rac1 associated GEF 1provided by HGNC
    Primary source
    HGNC:HGNC:11805
    See related
    Ensembl:ENSG00000156299 MIM:600687
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIAM-1
    Summary
    This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]
    Expression
    Broad expression in esophagus (RPKM 7.7), skin (RPKM 6.8) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TIAM1 in Genome Data Viewer
    Location:
    21q22.11
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (31118418..31559977, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (32490736..32931400, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene keratin associated protein 19-8 Neighboring gene ubiquitin protein ligase E3A pseudogene 2 Neighboring gene uncharacterized LOC107985487 Neighboring gene uncharacterized LOC105372777 Neighboring gene mitochondrial transcription rescue factor 1 pseudogene Neighboring gene TIAM1 antisense RNA 1 Neighboring gene uncharacterized LOC107985488 Neighboring gene F-box and WD repeat domain containing 11 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study.
    GeneReviews: Not available
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    GeneReviews: Not available
    Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ36302

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Wnt signaling pathway, planar cell polarity pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in activation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of dopaminergic neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of non-canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    involved_in small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell-cell contact zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor TIAM1
    Names
    T cell lymphoma invasion and metastasis 1
    T-lymphoma invasion and metastasis-inducing protein 1
    human T-lymphoma invasion and metastasis inducing TIAM1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001353684.2NP_001340613.1  rho guanine nucleotide exchange factor TIAM1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000246
      Consensus CDS
      CCDS86983.1
      Related
      ENSP00000490786.1, ENST00000636887.1
      Conserved Domains (2) summary
      smart00325
      Location:77266
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01255
      Location:268439
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    2. NM_001353685.2NP_001340614.1  rho guanine nucleotide exchange factor TIAM1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AP000246
      Conserved Domains (2) summary
      smart00325
      Location:52241
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01255
      Location:243414
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    3. NM_001353686.2NP_001340615.1  rho guanine nucleotide exchange factor TIAM1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248
      Conserved Domains (5) summary
      cd01818
      Location:766841
      TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor
      smart00325
      Location:10191208
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12101381
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    4. NM_001353687.2NP_001340616.1  rho guanine nucleotide exchange factor TIAM1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248
      Conserved Domains (5) summary
      cd01818
      Location:741816
      TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor
      smart00325
      Location:10191208
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:821900
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12101381
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    5. NM_001353688.1NP_001340617.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248, AP000251, AP000563
      Consensus CDS
      CCDS13609.1
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    6. NM_001353689.1NP_001340618.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248, AP000251, AP000563
      Consensus CDS
      CCDS13609.1
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    7. NM_001353690.1NP_001340619.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248, AP000251
      Consensus CDS
      CCDS13609.1
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    8. NM_001353691.1NP_001340620.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248, AP000251, AP000563
      Consensus CDS
      CCDS13609.1
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    9. NM_001353692.1NP_001340621.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248, AP000251, AP000563
      Consensus CDS
      CCDS13609.1
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    10. NM_001353693.1NP_001340622.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248, AP000251, AP000563
      Consensus CDS
      CCDS13609.1
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    11. NM_001353694.2NP_001340623.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248
      Consensus CDS
      CCDS13609.1
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    12. NM_003253.3NP_003244.2  rho guanine nucleotide exchange factor TIAM1 isoform 1

      See identical proteins and their annotated locations for NP_003244.2

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248, AP000251, AP000563
      Consensus CDS
      CCDS13609.1
      UniProtKB/Swiss-Prot
      Q13009
      Related
      ENSP00000286827.3, ENST00000286827.7
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

      Range
      31118418..31559977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529712.1XP_011528014.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

      See identical proteins and their annotated locations for XP_011528014.1

      UniProtKB/Swiss-Prot
      Q13009
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    2. XM_017028448.1XP_016883937.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

      UniProtKB/Swiss-Prot
      Q13009
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    3. XM_024452127.1XP_024307895.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    4. XM_005261040.2XP_005261097.1  rho guanine nucleotide exchange factor TIAM1 isoform X2

      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam00169
      Location:445547
      PH; PH domain
      cl00155
      Location:766841
      UBQ; Ubiquitin-like proteins
    5. XM_011529713.1XP_011528015.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

      See identical proteins and their annotated locations for XP_011528015.1

      UniProtKB/Swiss-Prot
      Q13009
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    6. XM_005261038.3XP_005261095.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

      See identical proteins and their annotated locations for XP_005261095.1

      UniProtKB/Swiss-Prot
      Q13009
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    7. XM_017028450.1XP_016883939.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

      UniProtKB/Swiss-Prot
      Q13009
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    8. XM_017028451.2XP_016883940.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

      UniProtKB/Swiss-Prot
      Q13009
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
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