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    Adipor2 adiponectin receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 68465, updated on 8-Dec-2018

    Summary

    Official Symbol
    Adipor2provided by MGI
    Official Full Name
    adiponectin receptor 2provided by MGI
    Primary source
    MGI:MGI:93830
    See related
    Ensembl:ENSMUSG00000030168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ADCR2; Paqr2; AI115388; AW554121; D6Ucla1e; 1110001I14Rik
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 96.4), liver adult (RPKM 91.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Adipor2 in Genome Data Viewer
    Location:
    6 F1; 6 56.78 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (119353150..119417483, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (119303168..119367501, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, L type, alpha 1C subunit Neighboring gene decapping mRNA 1B Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 4 Neighboring gene leucine-rich repeats and transmembrane domains 2 Neighboring gene wingless-type MMTV integration site family, member 5B Neighboring gene predicted gene, 40397 Neighboring gene F-box and leucine-rich repeat protein 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem (from REACTOME)
      AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • AMPK signaling pathway, organism-specific biosystem (from KEGG)
      AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • AMPK signaling pathway, conserved biosystem (from KEGG)
      AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
      Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
      Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
      Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Leptin and adiponectin, organism-specific biosystem (from WikiPathways)
      Leptin and adiponectin, organism-specific biosystemProposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in [http://www.ncbi.nlm.nih.gov/pubmed/16497175 Dyck et al.].
    • Longevity regulating pathway, organism-specific biosystem (from KEGG)
      Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    adipokinetic hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    adiponectin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    adiponectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    adiponectin-activated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adiponectin-activated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adiponectin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adiponectin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hormone-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    vascular wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    adiponectin receptor protein 2
    Names
    progestin and adipoQ receptor family member 2
    progestin and adipoQ receptor family member II

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355692.1NP_001342621.1  adiponectin receptor protein 2

      Status: VALIDATED

      Source sequence(s)
      AC115816, AC126607
      Conserved Domains (1) summary
      pfam03006
      Location:140363
      HlyIII; Haemolysin-III related
    2. NM_197985.4NP_932102.2  adiponectin receptor protein 2

      See identical proteins and their annotated locations for NP_932102.2

      Status: VALIDATED

      Source sequence(s)
      AC115816, AC126607
      Consensus CDS
      CCDS20473.1
      UniProtKB/Swiss-Prot
      Q8BQS5
      UniProtKB/TrEMBL
      Q53YY3
      Related
      ENSMUSP00000032272.6, ENSMUST00000032272.12
      Conserved Domains (1) summary
      pfam03006
      Location:140363
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      119353150..119417483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506538.2XP_006506601.1  adiponectin receptor protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BQS5
      UniProtKB/TrEMBL
      Q53YY3
      Related
      ENSMUSP00000126138.1, ENSMUST00000169744.7
      Conserved Domains (1) summary
      pfam03006
      Location:140363
      HlyIII; Haemolysin-III related
    2. XM_011241448.2XP_011239750.1  adiponectin receptor protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011239750.1

      UniProtKB/Swiss-Prot
      Q8BQS5
      UniProtKB/TrEMBL
      Q53YY3
      Conserved Domains (1) summary
      pfam03006
      Location:140363
      HlyIII; Haemolysin-III related
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