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    STAU1 staufen double-stranded RNA binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 6780, updated on 11-Sep-2019

    Summary

    Official Symbol
    STAU1provided by HGNC
    Official Full Name
    staufen double-stranded RNA binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:11370
    See related
    Ensembl:ENSG00000124214 MIM:601716
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STAU; PPP1R150
    Summary
    Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 41.4), thyroid (RPKM 35.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See STAU1 in Genome Data Viewer
    Location:
    20q13.13
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (49113339..49219295, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (47729876..47804907, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene CSE1L antisense RNA 1 Neighboring gene chromosome segregation 1 like Neighboring gene actin related protein 2/3 complex subunit 3 pseudogene 1 Neighboring gene DEAD-box helicase 27 Neighboring gene zinc finger NFX1-type containing 1 Neighboring gene Sharpr-MPRA regulatory region 13855 Neighboring gene ZNFX1 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 ribonucleoprotein complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 ribonucleoprotein complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 ribonucleoprotein complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Staufen1, vRNA and Gag are found in the same ribonucleoprotein (RNP) complex. The depletion of Staufen1 results in reduced Gag levels and deregulates the assembly of newly synthesized virions PubMed
    gag Interaction of HIV-1 Gag with staufen is mediated by staufen's dsRBD3 domain PubMed
    gag Staufen is incorporated into HIV-1 virions through association with HIV-1 genomic RNA and is implicated in HIV-1 genome selection and packaging into assembling virions, a process that is mediated by the Nucleocapsid domain of HIV-1 Gag PubMed
    gag Tandem affinity purification and mass spectrometry analysis identify HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 ribonucleoprotein complexes isolated from HIV-1-expressing cells PubMed
    gag EAP30 interacts with HIV-1 Gag and Staufen1 in live cell tri-molecular fluorescence complementary assay PubMed
    gag HIV-1 Gag and Stau1 interact in both membrane-associated and cytosolic complexes. Stau1 overexpression and depletion by RNAi modulate Gag multimerization PubMed
    gag The NC zinc fingers mediate Stau1/Gag interaction. The N-terminal domain (residues 26-37) of Stau1 is required for its function in Gag multimerization PubMed
    nucleocapsid gag Staufen is incorporated into HIV-1 virions through association with HIV-1 genomic RNA and is implicated in HIV-1 genome selection and packaging into assembling virions, a process that is mediated by the Nucleocapsid domain of HIV-1 Gag PubMed
    gag The NC zinc fingers mediate Stau1/Gag interaction. The N-terminal domain (residues 26-37) of Stau1 is required for its function in Gag multimerization PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ25010

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase 1 binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    modification of postsynaptic structure IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation by virus of viral protein levels in host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    membrane HDA PubMed 
    microtubule associated complex TAS
    Traceable Author Statement
    more info
    PubMed 
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    double-stranded RNA-binding protein Staufen homolog 1
    Names
    protein phosphatase 1, regulatory subunit 150
    staufen, RNA binding protein, homolog 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029453.2 RefSeqGene

      Range
      45926..120957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001037328.2NP_001032405.1  double-stranded RNA-binding protein Staufen homolog 1 isoform c

      See identical proteins and their annotated locations for NP_001032405.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (T5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant T2. The encoded isoform (c) is longer than isoform a. Both variants T5 and T6 encode the same isoform (c).
      Source sequence(s)
      AF061938, AK091405, BC010169, BC095397, BE439382, DB100321
      Consensus CDS
      CCDS33481.1
      UniProtKB/Swiss-Prot
      O95793
      UniProtKB/TrEMBL
      B3KRE0, Q6PJX3
      Conserved Domains (3) summary
      smart00358
      Location:105175
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:211277
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:373482
      Staufen_C; Staufen C-terminal domain
    2. NM_001319134.1NP_001306063.1  double-stranded RNA-binding protein Staufen homolog 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (T6) uses an alternate in-frame splice site in the 5' coding region compared to variant T2. The encoded isoform (c) is longer than isoform a. Both variants T5 and T6 encode the same isoform (c).
      Source sequence(s)
      AK091405, AY546099, BE439382, BQ649508, DB100321
      Consensus CDS
      CCDS33481.1
      UniProtKB/Swiss-Prot
      O95793
      UniProtKB/TrEMBL
      B3KRE0
      Related
      ENSP00000360893.3, ENST00000371828.7
      Conserved Domains (3) summary
      smart00358
      Location:105175
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:211277
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:373482
      Staufen_C; Staufen C-terminal domain
    3. NM_001319135.1NP_001306064.1  double-stranded RNA-binding protein Staufen homolog 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (T7) differs in the 5' UTR and the 5' coding region, and uses an upstream translation start site compared to variant T2. The encoded isoform (b) has a longer and distinct N-terminus compared to isoform a. Both variants T3 and T7 encode the same isoform (b).
      Source sequence(s)
      AB209561, AK091405, BE439382, BQ649508, DB086071
      Consensus CDS
      CCDS13414.1
      UniProtKB/Swiss-Prot
      O95793
      UniProtKB/TrEMBL
      B3KRE0, Q59F99
      Conserved Domains (3) summary
      smart00358
      Location:186250
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:286352
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:448557
      Staufen_C; Staufen C-terminal domain
    4. NM_001322927.1NP_001309856.1  double-stranded RNA-binding protein Staufen homolog 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL133174, BE439382, DA455473, DA858410
      Consensus CDS
      CCDS33481.1
      UniProtKB/Swiss-Prot
      O95793
      Related
      ENSP00000360867.1, ENST00000371802.5
      Conserved Domains (3) summary
      smart00358
      Location:105175
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:211277
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:373482
      Staufen_C; Staufen C-terminal domain
    5. NM_001322928.1NP_001309857.1  double-stranded RNA-binding protein Staufen homolog 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL133174, BE439382, DA455473, DA858410
      Conserved Domains (3) summary
      smart00358
      Location:145215
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:251317
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:413522
      Staufen_C; Staufen C-terminal domain
    6. NM_001322929.1NP_001309858.1  double-stranded RNA-binding protein Staufen homolog 1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL133174, BE439382, DA455473
      Consensus CDS
      CCDS13414.1
      UniProtKB/Swiss-Prot
      O95793
      Conserved Domains (3) summary
      smart00358
      Location:186250
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:286352
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:448557
      Staufen_C; Staufen C-terminal domain
    7. NM_001322930.1NP_001309859.1  double-stranded RNA-binding protein Staufen homolog 1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL133174, BE439382, DA455473
      Consensus CDS
      CCDS13414.1
      UniProtKB/Swiss-Prot
      O95793
      Conserved Domains (3) summary
      smart00358
      Location:186250
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:286352
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:448557
      Staufen_C; Staufen C-terminal domain
    8. NM_001322931.1NP_001309860.1  double-stranded RNA-binding protein Staufen homolog 1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL133174, BE439382, DA455473, DA858410
    9. NM_001322932.1NP_001309861.1  double-stranded RNA-binding protein Staufen homolog 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL133174, BE439382, DA455473
      Conserved Domains (3) summary
      smart00358
      Location:186256
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:292358
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:454563
      Staufen_C; Staufen C-terminal domain
    10. NM_001322933.1NP_001309862.1  double-stranded RNA-binding protein Staufen homolog 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL133174, BE439382, DA455473
      Conserved Domains (3) summary
      smart00358
      Location:186256
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:292358
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:454563
      Staufen_C; Staufen C-terminal domain
    11. NM_004602.3NP_004593.2  double-stranded RNA-binding protein Staufen homolog 1 isoform a

      See identical proteins and their annotated locations for NP_004593.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (T4) has an additional exon in the 5' UTR compared to T2, the most abundantly expressed transcript variant. T4 encodes the same isoform (a) of 496 amino acids as T2.
      Source sequence(s)
      AF061941, AK091405, BC001893, BC050432, BC095397, BE439382, DB100321
      Consensus CDS
      CCDS13415.1
      UniProtKB/Swiss-Prot
      O95793
      UniProtKB/TrEMBL
      B3KRE0
      Related
      ENSP00000345425.6, ENST00000340954.11
      Conserved Domains (3) summary
      smart00358
      Location:105169
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:205271
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:367476
      Staufen_C; Staufen C-terminal domain
    12. NM_017452.3NP_059346.2  double-stranded RNA-binding protein Staufen homolog 1 isoform a

      See identical proteins and their annotated locations for NP_059346.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (T2) is most abundantly expressed, and encodes the protein isoform (a) of 496 amino acids.
      Source sequence(s)
      AK091405, BC050432, BC095397, BE439382, DB100321
      Consensus CDS
      CCDS13415.1
      UniProtKB/Swiss-Prot
      O95793
      UniProtKB/TrEMBL
      B3KRE0
      Related
      ENSP00000353604.4, ENST00000360426.8
      Conserved Domains (3) summary
      smart00358
      Location:105169
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:205271
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:367476
      Staufen_C; Staufen C-terminal domain
    13. NM_017453.3NP_059347.2  double-stranded RNA-binding protein Staufen homolog 1 isoform b

      See identical proteins and their annotated locations for NP_059347.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (T3) differs in the 5' UTR and the 5' coding region, and uses an upstream translation start site compared to variant T2. The encoded isoform (b) has a longer and distinct N-terminus compared to isoform a. Both variants T3 and T7 encode the same isoform (b).
      Source sequence(s)
      AF061939, AK091405, BC095397, BE439382, DB100321
      Consensus CDS
      CCDS13414.1
      UniProtKB/Swiss-Prot
      O95793
      UniProtKB/TrEMBL
      B3KRE0
      Related
      ENSP00000360922.2, ENST00000371856.6
      Conserved Domains (3) summary
      smart00358
      Location:186250
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:286352
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:448557
      Staufen_C; Staufen C-terminal domain
    14. NM_017454.3NP_059348.2  double-stranded RNA-binding protein Staufen homolog 1 isoform a

      See identical proteins and their annotated locations for NP_059348.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (T1) lacks an exon in the 5' UTR compared to T2, the most abundantly expressed transcript variant. T1 encodes the same isoform (a) of 496 amino acids as T2.
      Source sequence(s)
      AK091405, BC050432, BC095397, BE439382, DB100321
      Consensus CDS
      CCDS13415.1
      UniProtKB/Swiss-Prot
      O95793
      UniProtKB/TrEMBL
      B3KRE0
      Related
      ENSP00000323443.7, ENST00000347458.9
      Conserved Domains (3) summary
      smart00358
      Location:105169
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:205271
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:367476
      Staufen_C; Staufen C-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

      Range
      49113339..49219295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028028.1XP_016883517.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X3

    2. XM_006723865.1XP_006723928.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006723928.1

      Conserved Domains (3) summary
      smart00358
      Location:186256
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:292358
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:454563
      Staufen_C; Staufen C-terminal domain
    3. XM_005260527.1XP_005260584.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X4

      See identical proteins and their annotated locations for XP_005260584.1

      UniProtKB/Swiss-Prot
      O95793
      Conserved Domains (3) summary
      smart00358
      Location:105175
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:211277
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:373482
      Staufen_C; Staufen C-terminal domain
    4. XM_011529015.1XP_011527317.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X2

      See identical proteins and their annotated locations for XP_011527317.1

      Conserved Domains (3) summary
      smart00358
      Location:145215
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:251317
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:413522
      Staufen_C; Staufen C-terminal domain
    5. XM_024451973.1XP_024307741.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X5

      Related
      ENSP00000484011.1, ENST00000614381.4
      Conserved Domains (3) summary
      smart00358
      Location:105169
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:205271
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:367476
      Staufen_C; Staufen C-terminal domain
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