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    SPTAN1 spectrin alpha, non-erythrocytic 1 [ Homo sapiens (human) ]

    Gene ID: 6709, updated on 24-Nov-2020

    Summary

    Official Symbol
    SPTAN1provided by HGNC
    Official Full Name
    spectrin alpha, non-erythrocytic 1provided by HGNC
    Primary source
    HGNC:HGNC:11273
    See related
    Ensembl:ENSG00000197694 MIM:182810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DEE5; NEAS; EIEE5; SPTA2
    Summary
    Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
    Expression
    Ubiquitous expression in brain (RPKM 87.7), testis (RPKM 42.9) and 24 other tissues See more
    Orthologs

    Genomic context

    See SPTAN1 in Genome Data Viewer
    Location:
    9q34.11
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    109.20201120 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128552564..128633662)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131314837..131395944)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene GLE1 RNA export mediator Neighboring gene uncharacterized LOC101929270 Neighboring gene RNA, U7 small nuclear 171 pseudogene Neighboring gene dynein 2 intermediate chain 2 Neighboring gene uncharacterized LOC105376287 Neighboring gene vesicle transport through interaction with t-SNAREs 1B pseudogene 4 Neighboring gene high mobility group AT-hook 1 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Early infantile epileptic encephalopathy 5
    MedGen: C3150731 OMIM: 613477 GeneReviews: Not available
    Compare labs
    Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of spectrin, alpha, non-erythrocytic 1 (SPTAN1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify spectrin alpha chain (SPTAN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify spectrin alpha chain (SPTAN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify spectrin alpha chain (SPTAN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify spectrin alpha chain (SPTAN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) (SPTAN1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    Vpr vpr HIV-1 Vpr upregulates SPTAN1 in HeLa cells within 12 hours of exposure PubMed
    retropepsin gag-pol A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ17738, FLJ44613

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    cadherin binding HDA PubMed 
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    MAPK cascade TAS
    Traceable Author Statement
    more info
     
    actin filament capping IEA
    Inferred from Electronic Annotation
    more info
     
    axon guidance TAS
    Traceable Author Statement
    more info
     
    cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum to Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular vesicle HDA PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    specific granule lumen TAS
    Traceable Author Statement
    more info
     
    spectrin TAS
    Traceable Author Statement
    more info
    PubMed 
    tertiary granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    spectrin alpha chain, non-erythrocytic 1
    Names
    alpha-II spectrin
    alpha-fodrin
    epididymis secretory sperm binding protein
    fodrin alpha chain
    spectrin, non-erythroid alpha chain
    spectrin, non-erythroid alpha subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027748.1 RefSeqGene

      Range
      5001..86108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130438.3NP_001123910.1  spectrin alpha chain, non-erythrocytic 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL356481
      Consensus CDS
      CCDS48036.1
      UniProtKB/Swiss-Prot
      Q13813
      Related
      ENSP00000361824.3, ENST00000372739.6
      Conserved Domains (5) summary
      cd11808
      Location:9711023
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:23322400
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:679890
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam08726
      Location:24072475
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam00435
      Location:16631765
      Spectrin; Spectrin repeat
    2. NM_001195532.2NP_001182461.1  spectrin alpha chain, non-erythrocytic 1 isoform 3

      See identical proteins and their annotated locations for NP_001182461.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AL356481
      Consensus CDS
      CCDS75914.1
      UniProtKB/Swiss-Prot
      Q13813
      Related
      ENSP00000350882.6, ENST00000358161.9
      Conserved Domains (5) summary
      cd11808
      Location:9711023
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:23072375
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:679890
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:16381742
      Spectrin; Spectrin repeat
      pfam08726
      Location:23822450
      EFhand_Ca_insen; Ca2+ insensitive EF hand
    3. NM_001363759.2NP_001350688.1  spectrin alpha chain, non-erythrocytic 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL356481
      Consensus CDS
      CCDS87695.1
      Related
      ENSP00000487444.1, ENST00000630866.1
      Conserved Domains (5) summary
      cd11808
      Location:9711023
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:23532421
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:679890
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:16631767
      Spectrin; Spectrin repeat
      pfam08726
      Location:24282496
      EFhand_Ca_insen; Ca2+ insensitive EF hand
    4. NM_001363765.2NP_001350694.1  spectrin alpha chain, non-erythrocytic 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL356481
      Consensus CDS
      CCDS87696.1
      Related
      ENSP00000486308.1, ENST00000630804.2
      Conserved Domains (5) summary
      cd11808
      Location:9711023
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:23122380
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:679890
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam08726
      Location:23872455
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam00435
      Location:16431745
      Spectrin; Spectrin repeat
    5. NM_001375310.1NP_001362239.1  spectrin alpha chain, non-erythrocytic 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL356481
    6. NM_001375311.2NP_001362240.1  spectrin alpha chain, non-erythrocytic 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL356481
      Conserved Domains (5) summary
      cd11808
      Location:9711023
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:23322400
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:679890
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam08726
      Location:24072475
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam00435
      Location:16631765
      Spectrin; Spectrin repeat
    7. NM_001375312.2NP_001362241.2  spectrin alpha chain, non-erythrocytic 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL356481
    8. NM_001375313.1NP_001362242.1  spectrin alpha chain, non-erythrocytic 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL356481
      Conserved Domains (5) summary
      cd11808
      Location:9711023
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:23262394
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:679890
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam08726
      Location:24012469
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam00435
      Location:16631765
      Spectrin; Spectrin repeat
    9. NM_001375314.2NP_001362243.1  spectrin alpha chain, non-erythrocytic 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL356481
      Conserved Domains (5) summary
      cd11808
      Location:9711023
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:23122380
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:679890
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam08726
      Location:23872455
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam00435
      Location:16431745
      Spectrin; Spectrin repeat
    10. NM_001375318.1NP_001362247.1  spectrin alpha chain, non-erythrocytic 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL356481
      Conserved Domains (5) summary
      cd11808
      Location:9831035
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:23652433
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:691902
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam08726
      Location:24402508
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam00435
      Location:16751777
      Spectrin; Spectrin repeat
    11. NM_003127.4NP_003118.2  spectrin alpha chain, non-erythrocytic 1 isoform 2

      See identical proteins and their annotated locations for NP_003118.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL356481
      Consensus CDS
      CCDS6905.1
      UniProtKB/Swiss-Prot
      Q13813
      Related
      ENSP00000361816.4, ENST00000372731.8
      Conserved Domains (6) summary
      cd11808
      Location:9711023
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:23272395
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:679890
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:16581762
      Spectrin; Spectrin repeat
      pfam08726
      Location:24022470
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam13499
      Location:23302395
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      128552564..128633662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717251.2XP_006717314.1  spectrin alpha chain, non-erythrocytic 1 isoform X8

      Conserved Domains (6) summary
      cd11808
      Location:9711023
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:23332401
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:679890
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:16431747
      Spectrin; Spectrin repeat
      pfam08726
      Location:24082476
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam13499
      Location:23362401
      EF-hand_7; EF-hand domain pair
    2. XM_006717250.1XP_006717313.1  spectrin alpha chain, non-erythrocytic 1 isoform X7

      Conserved Domains (6) summary
      cd11808
      Location:9831035
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:23382406
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:691902
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:16751779
      Spectrin; Spectrin repeat
      pfam08726
      Location:24132481
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam13499
      Location:23412406
      EF-hand_7; EF-hand domain pair
    3. XM_006717246.1XP_006717309.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

      Conserved Domains (6) summary
      cd11808
      Location:9831035
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:23602428
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:691902
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:16701774
      Spectrin; Spectrin repeat
      pfam08726
      Location:24352503
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam13499
      Location:23632428
      EF-hand_7; EF-hand domain pair
    4. XM_006717249.1XP_006717312.1  spectrin alpha chain, non-erythrocytic 1 isoform X6

      Conserved Domains (6) summary
      cd11808
      Location:9831035
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:23392407
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:691902
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:16701774
      Spectrin; Spectrin repeat
      pfam08726
      Location:24142482
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam13499
      Location:23422407
      EF-hand_7; EF-hand domain pair
    5. XM_006717252.3XP_006717315.1  spectrin alpha chain, non-erythrocytic 1 isoform X10

      Conserved Domains (6) summary
      cd11808
      Location:9831035
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:23242392
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:691902
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:16551759
      Spectrin; Spectrin repeat
      pfam08726
      Location:23992467
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam13499
      Location:23272392
      EF-hand_7; EF-hand domain pair
    6. XM_006717253.1XP_006717316.1  spectrin alpha chain, non-erythrocytic 1 isoform X11

      Conserved Domains (6) summary
      cd11808
      Location:9831035
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:23192387
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:691902
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:16501754
      Spectrin; Spectrin repeat
      pfam08726
      Location:23942462
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam13499
      Location:23222387
      EF-hand_7; EF-hand domain pair
    7. XM_006717247.2XP_006717310.1  spectrin alpha chain, non-erythrocytic 1 isoform X4

      Conserved Domains (6) summary
      cd11808
      Location:9831035
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      cd00051
      Location:23452413
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:691902
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:16551759
      Spectrin; Spectrin repeat
      pfam08726
      Location:24202488
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam13499
      Location:23482413
      EF-hand_7; EF-hand domain pair
    8. XM_017015060.1XP_016870549.1  spectrin alpha chain, non-erythrocytic 1 isoform X12

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