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    SNRPB2 small nuclear ribonucleoprotein polypeptide B2 [ Homo sapiens (human) ]

    Gene ID: 6629, updated on 21-Apr-2019

    Summary

    Official Symbol
    SNRPB2provided by HGNC
    Official Full Name
    small nuclear ribonucleoprotein polypeptide B2provided by HGNC
    Primary source
    HGNC:HGNC:11155
    See related
    Ensembl:ENSG00000125870 MIM:603520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Msl1; U2B''
    Summary
    The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 22.1), appendix (RPKM 20.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See SNRPB2 in Genome Data Viewer
    Location:
    20p12.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (16729964..16741772)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (16710609..16722417)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372542 Neighboring gene ribosomal protein L7a pseudogene 13 Neighboring gene otoraplin Neighboring gene uncharacterized LOC105372544 Neighboring gene RNA, U6 small nuclear 27, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat U2 snRNPs interact with the HIV-1 Tat cofactor TAT-SF1 and stimulate transcription from the HIV-1 LTR promoter PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, U2-snRNP, organism-specific biosystem (from KEGG)
      Spliceosome, U2-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • Spliceosome, U2-snRNP, conserved biosystem (from KEGG)
      Spliceosome, U2-snRNP, conserved biosystemStructural complex; Genetic information processing; Spliceosome
    • mRNA Processing, organism-specific biosystem (from WikiPathways)
      mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC24807, MGC45309

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    snRNP binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    U2 snRNP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    U2-type catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    U2-type precatalytic spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    U2 small nuclear ribonucleoprotein B''
    Names
    U2 snRNP B''
    small nuclear ribonucleoprotein polypeptide B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003092.5NP_003083.1  U2 small nuclear ribonucleoprotein B''

      See identical proteins and their annotated locations for NP_003083.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI741327, AL034428, BC018022, BM772256
      Consensus CDS
      CCDS13123.1
      UniProtKB/Swiss-Prot
      P08579
      Related
      ENSP00000246071.6, ENST00000246071.8
      Conserved Domains (2) summary
      cd12478
      Location:696
      RRM1_U2B; RNA recognition motif 1 in U2 small nuclear ribonucleoprotein B" (U2B") and similar proteins
      cd12481
      Location:146225
      RRM2_U2B; RNA recognition motif 2 found in vertebrate U2 small nuclear ribonucleoprotein B" (U2B")
    2. NM_198220.2NP_937863.1  U2 small nuclear ribonucleoprotein B''

      See identical proteins and their annotated locations for NP_937863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI741327, BC036737, BM772256, DA088017
      Consensus CDS
      CCDS13123.1
      UniProtKB/Swiss-Prot
      P08579
      Related
      ENSP00000367178.5, ENST00000377943.9
      Conserved Domains (2) summary
      cd12478
      Location:696
      RRM1_U2B; RNA recognition motif 1 in U2 small nuclear ribonucleoprotein B" (U2B") and similar proteins
      cd12481
      Location:146225
      RRM2_U2B; RNA recognition motif 2 found in vertebrate U2 small nuclear ribonucleoprotein B" (U2B")

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

      Range
      16729964..16741772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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