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    FSCN1 fascin actin-bundling protein 1 [ Homo sapiens (human) ]

    Gene ID: 6624, updated on 14-Oct-2018

    Summary

    Official Symbol
    FSCN1provided by HGNC
    Official Full Name
    fascin actin-bundling protein 1provided by HGNC
    Primary source
    HGNC:HGNC:11148
    See related
    Ensembl:ENSG00000075618 MIM:602689; Vega:OTTHUMG00000090599
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSN; SNL; p55; FAN1
    Summary
    This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
    Expression
    Broad expression in brain (RPKM 42.7), placenta (RPKM 36.2) and 24 other tissues See more
    Orthologs

    Genomic context

    See FSCN1 in Genome Data Viewer
    Location:
    7p22.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (5592805..5606656)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (5632436..5646287)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene actin beta Neighboring gene S100 calcium binding protein A11 pseudogene Neighboring gene uncharacterized LOC107986762 Neighboring gene VISTA enhancer hs1623 Neighboring gene ring finger protein 216 Neighboring gene RNF216 intronic transcript 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of fascin actin-bundling protein 1 (FSCN1) in human primary T cells PubMed
    Vif vif HIV-1 Vif upregulates the expression of fascin homolog 1, actin-bundling protein (FSCN1) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ38511, FLJ43305

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cadherin binding HDA PubMed 
    drug binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell motility IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell junction assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    establishment of apical/basal cell polarity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microspike assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microspike assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of extracellular matrix disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of filopodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of lamellipodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of podosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of microvillus assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell projection membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    filopodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    invadopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microspike IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    podosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    fascin
    Names
    55 kDa actin-bundling protein
    epididymis secretory sperm binding protein
    fascin homolog 1, actin-bundling protein
    singed-like (fascin homolog, sea urchin)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030004.1 RefSeqGene

      Range
      5001..18852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003088.3NP_003079.1  fascin

      See identical proteins and their annotated locations for NP_003079.1

      Status: REVIEWED

      Source sequence(s)
      AK095254, BC000521, BI546742, BU629782
      Consensus CDS
      CCDS5342.1
      UniProtKB/Swiss-Prot
      Q16658
      UniProtKB/TrEMBL
      B3KTA3
      Related
      ENSP00000371798.3, OTTHUMP00000115718, ENST00000382361.7, OTTHUMT00000207153
      Conserved Domains (2) summary
      cd00257
      Location:383493
      Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
      pfam06268
      Location:268378
      Fascin; Fascin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      Range
      5592805..5606656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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