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    SMO smoothened, frizzled class receptor [ Homo sapiens (human) ]

    Gene ID: 6608, updated on 11-Jun-2025
    Official Symbol
    SMOprovided by HGNC
    Official Full Name
    smoothened, frizzled class receptorprovided by HGNC
    Primary source
    HGNC:HGNC:11119
    See related
    Ensembl:ENSG00000128602 MIM:601500; AllianceGenome:HGNC:11119
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Gx; CRJS; PHLS; SMOH; FZD11
    Summary
    The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]
    Expression
    Broad expression in ovary (RPKM 15.6), endometrium (RPKM 13.9) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table
    See SMO in Genome Data Viewer
    Location:
    7q32.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (129188633..129213545)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (130501540..130526468)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (128828474..128853386)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:128767334-128767834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26623 Neighboring gene mitogen-activated protein kinase kinase 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:128789516-128790112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:128790113-128790709 Neighboring gene tetraspanin 33 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26625 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:128809737-128810606 Neighboring gene RNY1 pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18626 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:128856579-128857167 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26627 Neighboring gene Sharpr-MPRA regulatory region 13971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18627 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18628 Neighboring gene adenosylhomocysteinase like 2 Neighboring gene Sharpr-MPRA regulatory region 5606 Neighboring gene uncharacterized LOC124900234 Neighboring gene MPRA-validated peak6717 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:128979582-128980146 Neighboring gene uncharacterized LOC105375500

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cAMP-dependent protein kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxysterol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxysterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables patched binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables patched binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase A catalytic subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase A catalytic subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein sequestering activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein sequestering activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within astrocyte activation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within atrial septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cholesterol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cholesterol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within central nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within central nervous system neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cerebellar cortex morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in commissural neuron axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in contact inhibition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dentate gyrus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in determination of left/right asymmetry in lateral mesoderm IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in determination of left/right asymmetry in lateral mesoderm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within determination of left/right symmetry IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within developmental growth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within digestive tract development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within dopaminergic neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within dorsal/ventral neural tube patterning IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within dorsal/ventral pattern formation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within embryonic organ development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within epithelial-mesenchymal cell signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in forebrain morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in forebrain morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of hair follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hair follicle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heart looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heart looping ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within heart morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within left/right axis specification IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mammary gland epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesenchymal to epithelial transition involved in metanephric renal vesicle formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesenchymal to epithelial transition involved in metanephric renal vesicle formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in midgut development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in midgut development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within myoblast migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of hair follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neural crest cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within ossification IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within pancreas morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pattern specification process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within pattern specification process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of branching involved in ureteric bud morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of heart morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of heart morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of somatic stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to inositol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in smooth muscle tissue development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in smoothened signaling pathway IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in somite development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in somite development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spinal cord dorsal/ventral patterning IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within thalamus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within type B pancreatic cell development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventral midline determination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventral midline determination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in 9+0 non-motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary membrane TAS
    Traceable Author Statement
    more info
     
    located_in ciliary tip TAS
    Traceable Author Statement
    more info
     
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cilium TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane bounded cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    protein smoothened
    Names
    frizzled family member 11
    protein Gx
    seven transmembrane helix receptor
    smoothened homolog
    smoothened, frizzled family receptor
    smoothened, seven transmembrane spanning receptor

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023340.2 RefSeqGene

      Range
      4762..29674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1393

    mRNA and Protein(s)

    1. NM_005631.5NP_005622.1  protein smoothened precursor

      See identical proteins and their annotated locations for NP_005622.1

      Status: REVIEWED

      Source sequence(s)
      AC011005
      Consensus CDS
      CCDS5811.1
      UniProtKB/Swiss-Prot
      A4D1K5, Q99835
      Related
      ENSP00000249373.3, ENST00000249373.8
      Conserved Domains (2) summary
      cd07451
      Location:66196
      CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
      pfam01534
      Location:221550
      Frizzled; Frizzled/Smoothened family membrane region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      129188633..129213545
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420759.1XP_047276715.1  protein smoothened isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      130501540..130526468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358862.1XP_054214837.1  protein smoothened isoform X1