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    INTS3 integrator complex subunit 3 [ Homo sapiens (human) ]

    Gene ID: 65123, updated on 7-Oct-2018

    Summary

    Official Symbol
    INTS3provided by HGNC
    Official Full Name
    integrator complex subunit 3provided by HGNC
    Primary source
    HGNC:HGNC:26153
    See related
    Ensembl:ENSG00000143624 MIM:611347; Vega:OTTHUMG00000037089
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INT3; SOSSA; SOSS-A; C1orf60; C1orf193
    Summary
    The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016]
    Expression
    Ubiquitous expression in testis (RPKM 20.6), ovary (RPKM 17.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See INTS3 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (153728067..153774808)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153700526..153746555)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene natriuretic peptide receptor 1 Neighboring gene microRNA 8083 Neighboring gene gem nuclear organelle associated protein 2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 372, pseudogene Neighboring gene solute carrier family 27 member 3 Neighboring gene uncharacterized LOC105371448 Neighboring gene immunoglobulin superfamily DCC subclass member 3 pseudogene Neighboring gene GATA zinc finger domain containing 2B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • RNA polymerase II transcribes snRNA genes, organism-specific biosystem (from REACTOME)
      RNA polymerase II transcribes snRNA genes, organism-specific biosystemSmall nuclear RNAs (snRNAs) play key roles in splicing and some of them, specifically the U1 and U2 snRNAs, are encoded by multicopy snRNA gene clusters containing tandem arrays of genes, about 30 in...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ21919, FLJ44849, DKFZp686E1950, DKFZp781I1253, DKFZp686O20115

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    snRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    snRNA transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    SOSS complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integrator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    integrator complex subunit 3
    Names
    SOSS complex subunit A
    sensor of single-strand DNA complex subunit A
    sensor of ssDNA subunit A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050682.1 RefSeqGene

      Range
      5018..51759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001324475.1NP_001311404.1  integrator complex subunit 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK290025, AL513523, BX110564, CR749376
      Consensus CDS
      CCDS1052.1
      UniProtKB/Swiss-Prot
      Q68E01
      Related
      ENSP00000404290.2, ENST00000435409.6
      Conserved Domains (1) summary
      pfam10189
      Location:270494
      Ints3; Integrator complex subunit 3
    2. NM_023015.4NP_075391.3  integrator complex subunit 3

      See identical proteins and their annotated locations for NP_075391.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL513523, BC105092, BX110564, CR749376
      Consensus CDS
      CCDS1052.1
      UniProtKB/Swiss-Prot
      Q68E01
      Related
      ENSP00000318641.2, OTTHUMP00000035161, ENST00000318967.6, OTTHUMT00000090045
      Conserved Domains (1) summary
      pfam10189
      Location:270494
      Ints3; Integrator complex subunit 3

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      153728067..153774808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p12 ALT_REF_LOCI_1

    Genomic

    1. NW_003315905.1 Reference GRCh38.p12 ALT_REF_LOCI_1

      Range
      44768..91509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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