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    SFRP1 secreted frizzled related protein 1 [ Homo sapiens (human) ]

    Gene ID: 6422, updated on 12-Aug-2018
    Official Symbol
    SFRP1provided by HGNC
    Official Full Name
    secreted frizzled related protein 1provided by HGNC
    Primary source
    HGNC:HGNC:10776
    See related
    Ensembl:ENSG00000104332 MIM:604156; Vega:OTTHUMG00000164074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FRP; FRP1; FrzA; FRP-1; SARP2
    Summary
    This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
    Expression
    Broad expression in endometrium (RPKM 97.0), fat (RPKM 58.4) and 17 other tissues See more
    Orthologs
    See SFRP1 in Genome Data Viewer
    Location:
    8p11.21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (41261957..41309471, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (41119476..41166990, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 356, pseudogene Neighboring gene uncharacterized LOC105379771 Neighboring gene microRNA 548ao Neighboring gene ribosomal protein S29 pseudogene 2 Neighboring gene RNA, U6 small nuclear 895, pseudogene Neighboring gene uncharacterized LOC105379391 Neighboring gene small nucleolar RNA, C/D box 65B

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of secreted frizzled-related protein 1 (SFRP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 has the ability to induce expression of FRP-1 on peripheral blood mononuclear cells (PBMC) PubMed
    Envelope surface glycoprotein gp160, precursor env Antibodies raised against the human fusion regulatory protein 1 (FRP-1; CD98) molecule suppress cell fusion mediated by HIV-1 gp160 PubMed
    env Co-cultivation of PBMC with HIV-1 gp160-expressing HeLa cells results in the increased expression of FRP-1 on T cells PubMed

    Go to the HIV-1, Human Interaction Database

    • BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation, organism-specific biosystem (from WikiPathways)
      BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation, organism-specific biosystemThis pathway is based on figure 6 from Li et al. BMP2 is activated by cAMP which promotes WNT4 expression in Human Primary Endometrial Stromal Cells (HPESCs) through SMAD1/5/8. WNT4 then induces FOXO...
    • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
      Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
    • Negative regulation of TCF-dependent signaling by WNT ligand antagonists, organism-specific biosystem (from REACTOME)
      Negative regulation of TCF-dependent signaling by WNT ligand antagonists, organism-specific biosystemSeveral unrelated families of secreted proteins antagonize WNT signaling. Secreted frizzled-related proteins (sFRPs) have a cysteine rich domain (CRD) that is also found in FZD and ROR receptors, wh...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
    • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
      TCF dependent signaling in response to WNT, organism-specific biosystem19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of ...
    • Validated targets of C-MYC transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional repression, organism-specific biosystem
      Validated targets of C-MYC transcriptional repression
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Wnt-protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Wnt-protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    drug binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    frizzled binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Wnt signaling pathway involved in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    bone trabecula formation IEA
    Inferred from Electronic Annotation
    more info
     
    canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to BMP stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to X-ray IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to estradiol stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to fibroblast growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to heparin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to prostaglandin E stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to starvation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to vitamin D IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    convergent extension involved in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    digestive tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    dopaminergic neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    dorsal/ventral axis specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    female gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic progenitor cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hematopoietic stem cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of JUN kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of ossification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of planar cell polarity pathway involved in axis elongation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural crest cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    osteoblast differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    planar cell polarity pathway involved in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell-matrix adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of non-canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of branching involved in prostate gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell cycle process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of midbrain dopaminergic neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    somatic stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    stromal-epithelial cell signaling involved in prostate gland development IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen-containing extracellular matrix HDA PubMed 
    colocalizes_with collagen-containing extracellular matrix HDA PubMed 
    collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space HDA PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    secreted frizzled-related protein 1
    Names
    SARP-2
    frizzled-related protein
    sFRP-1
    secreted apoptosis-related protein 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003012.4NP_003003.3  secreted frizzled-related protein 1 precursor

      See identical proteins and their annotated locations for NP_003003.3

      Status: REVIEWED

      Source sequence(s)
      BC036503, BQ002015, CB956696, CN271890, DA571541
      Consensus CDS
      CCDS34886.1
      UniProtKB/Swiss-Prot
      Q8N474
      Related
      ENSP00000220772.3, OTTHUMP00000225802, ENST00000220772.7, OTTHUMT00000377132
      Conserved Domains (2) summary
      cd07443
      Location:52175
      CRD_SFRP1; Cysteine-rich domain of the secreted frizzled-related protein 1 (SFRP1), a regulator of Wnt activity
      cd03580
      Location:183306
      NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

      Range
      41261957..41309471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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