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    SFRP1 secreted frizzled related protein 1 [ Homo sapiens (human) ]

    Gene ID: 6422, updated on 23-Jun-2022

    Summary

    Official Symbol
    SFRP1provided by HGNC
    Official Full Name
    secreted frizzled related protein 1provided by HGNC
    Primary source
    HGNC:HGNC:10776
    See related
    Ensembl:ENSG00000104332 MIM:604156; AllianceGenome:HGNC:10776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FRP; FRP1; FrzA; FRP-1; SARP2
    Summary
    This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
    Expression
    Broad expression in endometrium (RPKM 97.0), fat (RPKM 58.4) and 17 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SFRP1 in Genome Data Viewer
    Location:
    8p11.21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (41261962..41309473, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (41535586..41583179, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (41119481..41166992, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1363 Neighboring gene uncharacterized LOC105379771 Neighboring gene microRNA 548ao Neighboring gene ribosomal protein S29 pseudogene 2 Neighboring gene RNA, U6 small nuclear 895, pseudogene Neighboring gene Sharpr-MPRA regulatory region 9460 Neighboring gene small nucleolar RNA, C/D box 65B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of secreted frizzled-related protein 1 (SFRP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 has the ability to induce expression of FRP-1 on peripheral blood mononuclear cells (PBMC) PubMed
    Envelope surface glycoprotein gp160, precursor env Antibodies raised against the human fusion regulatory protein 1 (FRP-1; CD98) molecule suppress cell fusion mediated by HIV-1 gp160 PubMed
    env Co-cultivation of PBMC with HIV-1 gp160-expressing HeLa cells results in the increased expression of FRP-1 on T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Wnt-protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Wnt-protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables frizzled binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Wnt signaling pathway involved in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone trabecula formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to BMP stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to X-ray IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to estradiol stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to fibroblast growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to heparin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to prostaglandin E stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to starvation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to vitamin D IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in convergent extension involved in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in digestive tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dopaminergic neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dorsal/ventral axis specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hematopoietic progenitor cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hematopoietic stem cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of JUN kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of ossification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of planar cell polarity pathway involved in axis elongation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural crest cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in osteoblast differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in planar cell polarity pathway involved in axis elongation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in planar cell polarity pathway involved in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell-matrix adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of non-canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of branching involved in prostate gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell cycle process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of midbrain dopaminergic neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in somatic stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stromal-epithelial cell signaling involved in prostate gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    secreted frizzled-related protein 1
    Names
    SARP-2
    frizzled-related protein
    sFRP-1
    secreted apoptosis-related protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003012.5NP_003003.3  secreted frizzled-related protein 1 precursor

      See identical proteins and their annotated locations for NP_003003.3

      Status: REVIEWED

      Source sequence(s)
      AC104393, BC036503, BQ002015, CB956696, CN271890, DA571541
      Consensus CDS
      CCDS34886.1
      UniProtKB/Swiss-Prot
      Q8N474
      Related
      ENSP00000220772.3, ENST00000220772.8
      Conserved Domains (2) summary
      cd07443
      Location:52175
      CRD_SFRP1; Cysteine-rich domain of the secreted frizzled-related protein 1 (SFRP1), a regulator of Wnt activity
      cd03580
      Location:183306
      NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      41261962..41309473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      41535586..41583179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)