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    FN3K fructosamine 3 kinase [ Homo sapiens (human) ]

    Gene ID: 64122, updated on 17-Jun-2024

    Summary

    Official Symbol
    FN3Kprovided by HGNC
    Official Full Name
    fructosamine 3 kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:24822
    See related
    Ensembl:ENSG00000167363 MIM:608425; AllianceGenome:HGNC:24822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. [provided by RefSeq, Feb 2012]
    Expression
    Broad expression in kidney (RPKM 47.7), brain (RPKM 22.0) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FN3K in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (82735615..82751196)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (83610119..83625854)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80693491..80709072)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9227 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80687657-80688157 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80692522-80693234 Neighboring gene fructosamine 3 kinase related protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80693947-80694659 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80694660-80695371 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80701509-80702145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9229 Neighboring gene Sharpr-MPRA regulatory region 591 Neighboring gene tubulin folding cofactor D Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13015 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80747669-80748170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80751687-80752407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80786629-80787475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80795429-80795930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80802695-80803196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80803197-80803696 Neighboring gene zinc finger protein 750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13016 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80807949-80808451 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80817109-80817884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80824049-80824550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80824551-80825050 Neighboring gene uncharacterized LOC124904096 Neighboring gene TBCD intron CAGE-defined B cell enhancer

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry.
    EBI GWAS Catalog
    Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
    EBI GWAS Catalog
    Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kinase activity TAS
    Traceable Author Statement
    more info
     
    enables protein-fructosamine 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-fructosamine 3-kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein-ribulosamine 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in fructosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fructoselysine metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    involved_in protein deglycation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    fructosamine-3-kinase
    Names
    protein-psicosamine 3-kinase FN3K
    protein-ribulosamine 3-kinase FN3K
    NP_071441.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022158.4NP_071441.1  fructosamine-3-kinase

      See identical proteins and their annotated locations for NP_071441.1

      Status: VALIDATED

      Source sequence(s)
      AC024361
      Consensus CDS
      CCDS11818.1
      UniProtKB/Swiss-Prot
      Q9H479
      Related
      ENSP00000300784.7, ENST00000300784.8
      Conserved Domains (1) summary
      cl21453
      Location:21309
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      82735615..82751196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      83610119..83625854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)