CEACAM1 CEA cell adhesion molecule 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CEACAM1provided by HGNC
Official Full Name: CEA cell adhesion molecule 1provided by HGNC
Primary source: HGNC:HGNC:1814
See related: Ensembl:ENSG00000079385 MIM:109770
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BGP; BGP1; BGPI
Summary: This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
Expression: Biased expression in colon (RPKM 99.7), esophagus (RPKM 21.9) and 12 other tissues See more
Orthologs: all
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Genomic context

Location:: 19q13.2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109.20210226	current	GRCh38.p13 (GCF_000001405.39)	19	NC_000019.10 (42507306..42528482, complement)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (43011458..43032633, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural characterization of a dimeric complex between the short cytoplasmic domain of CEACAM1 and the pseudo tetramer of S100A10-Annexin A2 using NMR and molecular dynamics.
Title: Structural characterization of a dimeric complex between the short cytoplasmic domain of CEACAM1 and the pseudo tetramer of S100A10-Annexin A2 using NMR and molecular dynamics.
Association of circulating CEACAM1 levels and insulin sensitivity in gestational diabetes mellitus.
Title: Association of circulating CEACAM1 levels and insulin sensitivity in gestational diabetes mellitus.
Loss of the adhesion molecule CEACAM1 is associated with early biochemical recurrence in TMPRSS2:ERG fusion-positive prostate cancers.
Title: Loss of the adhesion molecule CEACAM1 is associated with early biochemical recurrence in TMPRSS2:ERG fusion-positive prostate cancers.
Hepatic CEACAM1 expression indicates donor liver quality and prevents early transplantation injury.
Title: Hepatic CEACAM1 expression indicates donor liver quality and prevents early transplantation injury.
Neutrophil Extracellular Trap-Associated CEACAM1 as a Putative Therapeutic Target to Prevent Metastatic Progression of Colon Carcinoma.
Title: Neutrophil Extracellular Trap-Associated CEACAM1 as a Putative Therapeutic Target to Prevent Metastatic Progression of Colon Carcinoma.
TIM-3 and CEACAM1 do not interact in cis and in trans.
Title: TIM-3 and CEACAM1 do not interact in cis and in trans.
Loss of CEACAM1 is associated with poor prognosis and peritoneal dissemination of patients with gastric cancer.
Title: Loss of CEACAM1 is associated with poor prognosis and peritoneal dissemination of patients with gastric cancer.
The aging-related upregulation of vascular CEACAM1 expression results in endothelial dysfunction that may promote atherosclerotic plaque formation in the presence of additional risk factors.
Title: Aging-related carcinoembryonic antigen-related cell adhesion molecule 1 signaling promotes vascular dysfunction.
FN-gamma could induce inflammatory responses, cellular growth and proliferation through the interaction of CEACAM1 (especially CEACAM1-S isoforms) and PI3K(p110delta)/Akt/mTOR in airway epithelial cells.
Title: Interferon gamma induces inflammatory responses through the interaction of CEACAM1 and PI3K in airway epithelial cells.
These results suggest the existence of an integrin-beta1 - and CEACAM1- or CEACAM5-dependent type IV secretion system delivery pathway for Helicobacter pylori CagA, which is clearly independent of VacA.
Title: Expression of CEACAM1 or CEACAM5 in AZ-521 cells restores the type IV secretion deficiency for translocation of CagA by Helicobacter pylori.

Submit: New GeneRIF Correction See all GeneRIFs (205)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in human primary T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-17429 (e-PCR)
- UniSTS:20736

D19S1014 (e-PCR)
- UniSTS:80201

SHGC-35228 (e-PCR)
- UniSTS:70555

STS-AA024986 (e-PCR)
- UniSTS:55717

STS-M72238 (e-PCR)
- UniSTS:55230

SHGC-35229 (e-PCR)
- UniSTS:51950

Homology

Homologs of the CEACAM1 gene: The CEACAM1 gene is conserved in chimpanzee, dog, mouse, and rat.
Orthologs from Annotation Pipeline: 62 organisms have orthologs with human gene CEACAM1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
actin binding	IPI Inferred from Physical Interaction more info	PubMed
bile acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info
filamin binding	IPI Inferred from Physical Interaction more info	PubMed
identical protein binding	IDA Inferred from Direct Assay more info	PubMed
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
kinase binding	IPI Inferred from Physical Interaction more info	PubMed
molecular_function	ND No biological Data available more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein dimerization activity	ISS Inferred from Sequence or Structural Similarity more info
protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
angiogenesis	NAS Non-traceable Author Statement more info	PubMed
bile acid and bile salt transport	ISS Inferred from Sequence or Structural Similarity more info
blood vessel development	ISS Inferred from Sequence or Structural Similarity more info
cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
cell migration	NAS Non-traceable Author Statement more info	PubMed
cell-cell adhesion via plasma-membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
common myeloid progenitor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
granulocyte colony-stimulating factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
homophilic cell adhesion via plasma membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
homophilic cell adhesion via plasma membrane adhesion molecules	NAS Non-traceable Author Statement more info	PubMed
insulin catabolic process	ISS Inferred from Sequence or Structural Similarity more info
insulin receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
integrin-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
leukocyte migration	TAS Traceable Author Statement more info
negative regulation of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cytotoxic T cell degranulation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of fatty acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of granulocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of hepatocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of interleukin-1 production	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of platelet aggregation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of vascular permeability	ISS Inferred from Sequence or Structural Similarity more info
neutrophil degranulation	TAS Traceable Author Statement more info
positive regulation of vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
regulation of blood vessel remodeling	ISS Inferred from Sequence or Structural Similarity more info
regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
regulation of endothelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
regulation of epidermal growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
regulation of homophilic cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
regulation of phosphatidylinositol 3-kinase signaling	ISS Inferred from Sequence or Structural Similarity more info
regulation of sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
wound healing, spreading of cells	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with T cell receptor complex	IDA Inferred from Direct Assay more info	PubMed
adherens junction	ISS Inferred from Sequence or Structural Similarity more info
apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
cell junction	IDA Inferred from Direct Assay more info	PubMed
cell junction	ISS Inferred from Sequence or Structural Similarity more info
cell surface	IDA Inferred from Direct Assay more info	PubMed
cell surface	ISS Inferred from Sequence or Structural Similarity more info
cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
extracellular exosome	HDA more info	PubMed
integral component of membrane	IDA Inferred from Direct Assay more info	PubMed
integral component of plasma membrane	NAS Non-traceable Author Statement more info	PubMed
lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
membrane	TAS Traceable Author Statement more info	PubMed
microvillus membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
specific granule membrane	TAS Traceable Author Statement more info
tertiary granule membrane	TAS Traceable Author Statement more info
transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carcinoembryonic antigen-related cell adhesion molecule 1

Names: CD66a antigen; antigen CD66; carcinoembryonic antigen related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029051.2 RefSeqGene

Range

5029..26204

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001024912.3 → NP_001020083.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001020083.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. This variant has been referred to by multiple names, including BGPc, transmembrane carcinoembryonic antigen 3, TM3-CEA, and CEACAM1-4S.

Source sequence(s)

AC004785, BC014473, BC024164, DA432598, X16354

Consensus CDS

CCDS46089.1

UniProtKB/Swiss-Prot

P13688

UniProtKB/TrEMBL

Q3KRG8

Related

ENSP00000384709.3, ENST00000403444.7

Conserved Domains (7) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam07679
Location:317 → 408

I-set; Immunoglobulin I-set domain

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain

pfam15756
Location:419 → 451

DUF4690; Domain of unknown function (DUF4690)

cl11960
Location:340 → 415

Ig; Immunoglobulin domain
NM_001184813.2 → NP_001171742.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 4 precursor

See identical proteins and their annotated locations for NP_001171742.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate, in-frame, exon, compared to variant 1. The resulting protein (isoform 3) is shorter when it was compared to isoform 1.

Source sequence(s)

AC004785, DA432598, X14831

Consensus CDS

CCDS54273.1

UniProtKB/Swiss-Prot

P13688

Related

ENSP00000244291.6, ENST00000352591.9

Conserved Domains (4) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain
NM_001184815.2 → NP_001171744.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 3 precursor

See identical proteins and their annotated locations for NP_001171744.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has one and lacks a different alternate, in-frame, segment, compared to variant 1. The resulting protein (isoform 3) is shorter when it was compared to isoform 1. This variant has been referred to as 'alternative spliced isoform 3S' and 'short form 3'.

Source sequence(s)

AC004785, AK314211, M76743, X16354

Consensus CDS

CCDS54274.1

UniProtKB/Swiss-Prot

P13688

Related

ENSP00000351165.2, ENST00000358394.7

Conserved Domains (4) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain
NM_001184816.2 → NP_001171745.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 5 precursor

See identical proteins and their annotated locations for NP_001171745.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two coding region segments, one of which shifts the reading frame, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct C-terminus when it is compared to isoform 1.

Source sequence(s)

AC004785, AY766113, DA432598, X16354

Consensus CDS

CCDS54272.1

UniProtKB/Swiss-Prot

P13688

Related

ENSP00000384083.1, ENST00000403461.5

Conserved Domains (5) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain

pfam15756
Location:323 → 355

DUF4690; Domain of unknown function (DUF4690)
NM_001205344.2 → NP_001192273.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 6 precursor

See identical proteins and their annotated locations for NP_001192273.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks a segment, which results in a frameshift, compared to variant 1. The resulting protein (isoform 6) has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL833584, BC014473, BU161659, DA432598, J03858, X14831

UniProtKB/Swiss-Prot

P13688

Conserved Domains (4) summary

cd05740
Location:146 → 233

Ig_CEACAM; Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cl11960
Location:340 → 415

Ig; Immunoglobulin domain
NM_001712.5 → NP_001703.2 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001703.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). This variant has been referred to by multiple names, including transmembrane carcinoembryonic antigen BGPa, TM1-CEA, and CEACAM1-4L.

Source sequence(s)

AC004785, DA432598, X16354

Consensus CDS

CCDS12609.1

UniProtKB/Swiss-Prot

P13688

Related

ENSP00000161559.6, ENST00000161559.11

Conserved Domains (7) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam07679
Location:317 → 408

I-set; Immunoglobulin I-set domain

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain

pfam15756
Location:419 → 451

DUF4690; Domain of unknown function (DUF4690)

cl11960
Location:340 → 415

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p13 Primary Assembly

Range

42507306..42528482 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011527206.2 → XP_011525508.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform X1

See identical proteins and their annotated locations for XP_011525508.1

UniProtKB/Swiss-Prot

P13688

Conserved Domains (4) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain