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    CEACAM1 carcinoembryonic antigen related cell adhesion molecule 1 [ Homo sapiens (human) ]

    Gene ID: 634, updated on 19-Aug-2018

    Summary

    Official Symbol
    CEACAM1provided by HGNC
    Official Full Name
    carcinoembryonic antigen related cell adhesion molecule 1provided by HGNC
    Primary source
    HGNC:HGNC:1814
    See related
    Ensembl:ENSG00000079385 MIM:109770; Vega:OTTHUMG00000151078
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BGP; BGP1; BGPI
    Summary
    This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
    Expression
    Biased expression in colon (RPKM 99.7), esophagus (RPKM 21.9) and 12 other tissues See more
    Orthologs

    Genomic context

    See CEACAM1 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (42507306..42528509, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43011458..43032661, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene LIPE antisense RNA 1 Neighboring gene RNA, U4 small nuclear 60, pseudogene Neighboring gene AN1-type zinc finger protein 5 pseudogene Neighboring gene uncharacterized LOC105372407 Neighboring gene carcinoembryonic antigen related cell adhesion molecule pseudogene 2 Neighboring gene carcinoembryonic antigen related cell adhesion molecule 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
    • Fibronectin matrix formation, organism-specific biosystem (from REACTOME)
      Fibronectin matrix formation, organism-specific biosystemFibronectin (FN1) is found in the extracellular matrix (ECM) of all cells as linear and branched networks that surround and connect neighbouring cells (Singh et al. 2010). Prior to matrix formation F...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    bile acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    filamin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    molecular_function ND
    No biological Data available
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein homodimerization activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    bile acid and bile salt transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    blood vessel development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell migration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell-cell adhesion via plasma-membrane adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    common myeloid progenitor cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    granulocyte colony-stimulating factor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    homophilic cell adhesion via plasma membrane adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    homophilic cell adhesion via plasma membrane adhesion molecules NAS
    Non-traceable Author Statement
    more info
    PubMed 
    insulin catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    insulin receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integrin-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    negative regulation of T cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cytotoxic T cell degranulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of granulocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of hepatocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of interleukin-1 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of platelet aggregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of vascular permeability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of vasculogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of blood vessel remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of endothelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of epidermal growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of homophilic cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of phosphatidylinositol 3-kinase signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    wound healing, spreading of cells IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with T cell receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    basal plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    lateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    specific granule membrane TAS
    Traceable Author Statement
    more info
     
    tertiary granule membrane TAS
    Traceable Author Statement
    more info
     
    transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    carcinoembryonic antigen-related cell adhesion molecule 1
    Names
    CD66a antigen
    antigen CD66
    carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029051.1 RefSeqGene

      Range
      5001..26204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001024912.2NP_001020083.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001020083.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. This variant has been referred to by multiple names, including BGPc, transmembrane carcinoembryonic antigen 3, TM3-CEA, and CEACAM1-4S.
      Source sequence(s)
      AC004785, BC014473, BC024164, DA432598, X16354
      Consensus CDS
      CCDS46089.1
      UniProtKB/Swiss-Prot
      P13688
      UniProtKB/TrEMBL
      Q3KRG8
      Related
      ENSP00000384709.3, OTTHUMP00000199189, ENST00000403444.7, OTTHUMT00000321413
      Conserved Domains (7) summary
      cd05740
      Location:146233
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:157233
      IG_like; Immunoglobulin like
      pfam07679
      Location:317408
      I-set; Immunoglobulin I-set domain
      pfam13895
      Location:240318
      Ig_2; Immunoglobulin domain
      pfam15756
      Location:419451
      DUF4690; Domain of unknown function (DUF4690)
      cl11960
      Location:340415
      Ig; Immunoglobulin domain
    2. NM_001184813.1NP_001171742.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001171742.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate, in-frame, exon, compared to variant 1. The resulting protein (isoform 3) is shorter when it was compared to isoform 1.
      Source sequence(s)
      AC004785, DA432598, X14831
      Consensus CDS
      CCDS54273.1
      UniProtKB/Swiss-Prot
      P13688
      Related
      ENSP00000244291.6, OTTHUMP00000270371, ENST00000352591.9, OTTHUMT00000464103
      Conserved Domains (4) summary
      cd05740
      Location:146233
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:157233
      IG_like; Immunoglobulin like
      pfam13895
      Location:240318
      Ig_2; Immunoglobulin domain
    3. NM_001184815.1NP_001171744.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001171744.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has one and lacks a different alternate, in-frame, segment, compared to variant 1. The resulting protein (isoform 3) is shorter when it was compared to isoform 1. This variant has been referred to as 'alternative spliced isoform 3S' and 'short form 3'.
      Source sequence(s)
      AC004785, AK314211, DA432598, M76743, X16354
      Consensus CDS
      CCDS54274.1
      UniProtKB/Swiss-Prot
      P13688
      Related
      ENSP00000351165.2, OTTHUMP00000270372, ENST00000358394.7, OTTHUMT00000464104
      Conserved Domains (4) summary
      cd05740
      Location:146233
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:157233
      IG_like; Immunoglobulin like
      pfam13895
      Location:240318
      Ig_2; Immunoglobulin domain
    4. NM_001184816.1NP_001171745.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform 5 precursor

      See identical proteins and their annotated locations for NP_001171745.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two coding region segments, one of which shifts the reading frame, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC004785, AY766113, DA432598, X16354
      Consensus CDS
      CCDS54272.1
      UniProtKB/Swiss-Prot
      P13688
      Related
      ENSP00000384083.1, OTTHUMP00000199193, ENST00000403461.5, OTTHUMT00000321417
      Conserved Domains (5) summary
      cd05740
      Location:146233
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:157233
      IG_like; Immunoglobulin like
      pfam13895
      Location:240318
      Ig_2; Immunoglobulin domain
      pfam15756
      Location:323355
      DUF4690; Domain of unknown function (DUF4690)
    5. NM_001205344.1NP_001192273.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform 6 precursor

      See identical proteins and their annotated locations for NP_001192273.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks a segment, which results in a frameshift, compared to variant 1. The resulting protein (isoform 6) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL833584, BC014473, BU161659, DA432598, J03858, X14831
      UniProtKB/Swiss-Prot
      P13688
      Conserved Domains (4) summary
      cd05740
      Location:146233
      Ig_CEACAM; Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      pfam13895
      Location:240318
      Ig_2; Immunoglobulin domain
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:340415
      Ig; Immunoglobulin domain
    6. NM_001712.4NP_001703.2  carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001703.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). This variant has been referred to by multiple names, including transmembrane carcinoembryonic antigen BGPa, TM1-CEA, and CEACAM1-4L.
      Source sequence(s)
      AC004785, DA432598, X16354
      Consensus CDS
      CCDS12609.1
      UniProtKB/Swiss-Prot
      P13688
      Related
      ENSP00000161559.6, OTTHUMP00000199069, ENST00000161559.10, OTTHUMT00000321190
      Conserved Domains (7) summary
      cd05740
      Location:146233
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:157233
      IG_like; Immunoglobulin like
      pfam07679
      Location:317408
      I-set; Immunoglobulin I-set domain
      pfam13895
      Location:240318
      Ig_2; Immunoglobulin domain
      pfam15756
      Location:419451
      DUF4690; Domain of unknown function (DUF4690)
      cl11960
      Location:340415
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      42507306..42528509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527206.2XP_011525508.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform X1

      See identical proteins and their annotated locations for XP_011525508.1

      UniProtKB/Swiss-Prot
      P13688
      Conserved Domains (4) summary
      cd05740
      Location:146233
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:157233
      IG_like; Immunoglobulin like
      pfam13895
      Location:240318
      Ig_2; Immunoglobulin domain
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