CEACAM1 carcinoembryonic antigen related cell adhesion molecule 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CEACAM1provided by HGNC
Official Full Name: carcinoembryonic antigen related cell adhesion molecule 1provided by HGNC
Primary source: HGNC:HGNC:1814
See related: Ensembl:ENSG00000079385 MIM:109770
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BGP; BGP1; BGPI
Summary: This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
Expression: Biased expression in colon (RPKM 99.7), esophagus (RPKM 21.9) and 12 other tissues See more
Orthologs: all

Genomic context

Location:: 19q13.2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109.20190607	current	GRCh38.p13 (GCF_000001405.39)	19	NC_000019.10 (42507306..42528482, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (43011458..43032661, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Together, these findings demonstrate that the outcome of gonococcal infection is determined by both the cell type-specific expression of human CEACAM1 and CEACAM5 and their specificity for the bacterial Opa variants expressed, which combine to determine the level of gonococcal association with the genital mucosa versus the extent of CEACAM-dependent inflammation and gonococcal clearance by neutrophils.
Title: Specific Binding to Differentially Expressed Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules Determines the Outcome of Neisseria gonorrhoeae Infections along the Female Reproductive Tract.
CEACAM1 overexpression in TSCC promoted tumor formation and growth.
Title: Carcinoembryonic antigen cell adhesion molecule 1 inhibits the antitumor effect of neutrophils in tongue squamous cell carcinoma.
IRF1 and a variant of heterogeneous nuclear ribonucleoprotein L coordinately regulate CEACAM1 transcription, alternative splicing, and translation and may significantly contribute to CEACAM1 silencing in cancer.
Title: Interferon regulatory factor 1 and a variant of heterogeneous nuclear ribonucleoprotein L coordinately silence the gene for adhesion protein CEACAM1.
Study concludes that CEACAM1 is an important regulator of virus-specific CD8+ T cell functions in mice and humans and represents a promising therapeutic target for modulating CD8+ T cells.
Title: CEACAM1 promotes CD8<sup>+</sup> T cell responses and improves control of a chronic viral infection.
regulator of local immune response in the liver, whereby CEACAM1S seems to control regulatory T cell induction
Title: Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice.
These experiments also confirmed that protein levels of CEACAM-1, which functions in cell adhesion, is dependent on LLO biosynthesis in vivo. Kato III cells and the MPDU1-rescued Kato IIIM cells therefore provide a novel model to examine the consequences of defective LLO biosynthesis both in vitro and in vivo.
Title: MPDU1 regulates CEACAM1 and cell adhesion in vitro and in vivo.
The MAPK-driven CEACAM1p activity is mediated by ETS1.
Title: Regulation of CEACAM1 Protein Expression by the Transcription Factor ETS-1 in BRAF-Mutant Human Metastatic Melanoma Cells.
CEACAM1 mRNA or protein expression are independent prognostic markers for ovarian cancer carcinomas.
Title: Prognostic Impact of CEACAM1 in Node-Negative Ovarian Cancer Patients.
We suggest that CEACAM1 could be a prognostic marker of oral squamous cell carcinoma and oral carcinoma in situ. Our most important finding was that it could help pathologists diagnosing oral carcinoma in situ
Title: Correlation between immunohistochemical staining of CEACAM1 and clinicopathological findings in oral pre-neoplastic lesions and squamous cell carcinoma.
GNAS mutation is a highly specific test for IPMN. When GNAS testing is added to CEA and KRAS, a significantly greater overall accuracy (86.2%) is achieved.
Title: Value of adding GNAS testing to pancreatic cyst fluid KRAS and carcinoembryonic antigen analysis for the diagnosis of intraductal papillary mucinous neoplasms.

Submit: New GeneRIF Correction See all GeneRIFs (188)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in human primary T cells	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
Extracellular matrix organization, organism-specific biosystem (from REACTOME)
Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
Fibronectin matrix formation, organism-specific biosystem (from REACTOME)
Fibronectin matrix formation, organism-specific biosystemFibronectin (FN1) is found in the extracellular matrix (ECM) of all cells as linear and branched networks that surround and connect neighbouring cells (Singh et al. 2010). Prior to matrix formation F...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Neutrophil degranulation, organism-specific biosystem (from REACTOME)
Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-17429 (e-PCR)
- UniSTS:20736

D19S1014 (e-PCR)
- UniSTS:80201

SHGC-35228 (e-PCR)
- UniSTS:70555

STS-AA024986 (e-PCR)
- UniSTS:55717

STS-M72238 (e-PCR)
- UniSTS:55230

SHGC-35229 (e-PCR)
- UniSTS:51950

Homology

Homologs of the CEACAM1 gene: The CEACAM1 gene is conserved in chimpanzee, dog, mouse, and rat.
Orthologs from Annotation Pipeline: 51 organisms have orthologs with human gene CEACAM1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
actin binding	IPI Inferred from Physical Interaction more info	PubMed
bile acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info
filamin binding	IPI Inferred from Physical Interaction more info	PubMed
identical protein binding	IDA Inferred from Direct Assay more info	PubMed
kinase binding	IPI Inferred from Physical Interaction more info	PubMed
molecular_function	ND No biological Data available more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein dimerization activity	ISS Inferred from Sequence or Structural Similarity more info
protein homodimerization activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
angiogenesis	NAS Non-traceable Author Statement more info	PubMed
bile acid and bile salt transport	ISS Inferred from Sequence or Structural Similarity more info
blood vessel development	ISS Inferred from Sequence or Structural Similarity more info
cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
cell migration	NAS Non-traceable Author Statement more info	PubMed
cell-cell adhesion via plasma-membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
common myeloid progenitor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
granulocyte colony-stimulating factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
homophilic cell adhesion via plasma membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
homophilic cell adhesion via plasma membrane adhesion molecules	NAS Non-traceable Author Statement more info	PubMed
insulin catabolic process	ISS Inferred from Sequence or Structural Similarity more info
insulin receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
integrin-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
leukocyte migration	TAS Traceable Author Statement more info
negative regulation of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cytotoxic T cell degranulation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of fatty acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of granulocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of hepatocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of interleukin-1 production	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of platelet aggregation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of vascular permeability	ISS Inferred from Sequence or Structural Similarity more info
neutrophil degranulation	TAS Traceable Author Statement more info
positive regulation of vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
regulation of blood vessel remodeling	ISS Inferred from Sequence or Structural Similarity more info
regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
regulation of endothelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
regulation of epidermal growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
regulation of homophilic cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
regulation of phosphatidylinositol 3-kinase signaling	ISS Inferred from Sequence or Structural Similarity more info
regulation of sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
wound healing, spreading of cells	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with T cell receptor complex	IDA Inferred from Direct Assay more info	PubMed
adherens junction	ISS Inferred from Sequence or Structural Similarity more info
apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
cell junction	IDA Inferred from Direct Assay more info	PubMed
cell junction	ISS Inferred from Sequence or Structural Similarity more info
cell surface	IDA Inferred from Direct Assay more info	PubMed
cell surface	ISS Inferred from Sequence or Structural Similarity more info
cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
extracellular exosome	HDA more info	PubMed
integral component of membrane	IDA Inferred from Direct Assay more info	PubMed
integral component of plasma membrane	NAS Non-traceable Author Statement more info	PubMed
lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
membrane	TAS Traceable Author Statement more info	PubMed
microvillus membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
specific granule membrane	TAS Traceable Author Statement more info
tertiary granule membrane	TAS Traceable Author Statement more info
transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carcinoembryonic antigen-related cell adhesion molecule 1

Names: CD66a antigen; antigen CD66; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029051.2 RefSeqGene

Range

5001..26204

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001024912.3 → NP_001020083.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001020083.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. This variant has been referred to by multiple names, including BGPc, transmembrane carcinoembryonic antigen 3, TM3-CEA, and CEACAM1-4S.

Source sequence(s)

AC004785, BC014473, BC024164, DA432598, X16354

Consensus CDS

CCDS46089.1

UniProtKB/Swiss-Prot

P13688

UniProtKB/TrEMBL

Q3KRG8

Related

ENSP00000384709.3, ENST00000403444.7

Conserved Domains (7) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam07679
Location:317 → 408

I-set; Immunoglobulin I-set domain

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain

pfam15756
Location:419 → 451

DUF4690; Domain of unknown function (DUF4690)

cl11960
Location:340 → 415

Ig; Immunoglobulin domain
NM_001184813.2 → NP_001171742.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 4 precursor

See identical proteins and their annotated locations for NP_001171742.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate, in-frame, exon, compared to variant 1. The resulting protein (isoform 3) is shorter when it was compared to isoform 1.

Source sequence(s)

AC004785, DA432598, X14831

Consensus CDS

CCDS54273.1

UniProtKB/Swiss-Prot

P13688

Related

ENSP00000244291.6, ENST00000352591.9

Conserved Domains (4) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain
NM_001184815.2 → NP_001171744.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 3 precursor

See identical proteins and their annotated locations for NP_001171744.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has one and lacks a different alternate, in-frame, segment, compared to variant 1. The resulting protein (isoform 3) is shorter when it was compared to isoform 1. This variant has been referred to as 'alternative spliced isoform 3S' and 'short form 3'.

Source sequence(s)

AC004785, AK314211, M76743, X16354

Consensus CDS

CCDS54274.1

UniProtKB/Swiss-Prot

P13688

Related

ENSP00000351165.2, ENST00000358394.7

Conserved Domains (4) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain
NM_001184816.2 → NP_001171745.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 5 precursor

See identical proteins and their annotated locations for NP_001171745.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two coding region segments, one of which shifts the reading frame, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct C-terminus when it is compared to isoform 1.

Source sequence(s)

AC004785, AY766113, DA432598, X16354

Consensus CDS

CCDS54272.1

UniProtKB/Swiss-Prot

P13688

Related

ENSP00000384083.1, ENST00000403461.5

Conserved Domains (5) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain

pfam15756
Location:323 → 355

DUF4690; Domain of unknown function (DUF4690)
NM_001205344.2 → NP_001192273.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 6 precursor

See identical proteins and their annotated locations for NP_001192273.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks a segment, which results in a frameshift, compared to variant 1. The resulting protein (isoform 6) has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL833584, BC014473, BU161659, DA432598, J03858, X14831

UniProtKB/Swiss-Prot

P13688

Conserved Domains (4) summary

cd05740
Location:146 → 233

Ig_CEACAM; Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cl11960
Location:340 → 415

Ig; Immunoglobulin domain
NM_001712.5 → NP_001703.2 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001703.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). This variant has been referred to by multiple names, including transmembrane carcinoembryonic antigen BGPa, TM1-CEA, and CEACAM1-4L.

Source sequence(s)

AC004785, DA432598, X16354

Consensus CDS

CCDS12609.1

UniProtKB/Swiss-Prot

P13688

Related

ENSP00000161559.6, ENST00000161559.11

Conserved Domains (7) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam07679
Location:317 → 408

I-set; Immunoglobulin I-set domain

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain

pfam15756
Location:419 → 451

DUF4690; Domain of unknown function (DUF4690)

cl11960
Location:340 → 415

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p13 Primary Assembly

Range

42507306..42528482 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011527206.2 → XP_011525508.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform X1

See identical proteins and their annotated locations for XP_011525508.1

UniProtKB/Swiss-Prot

P13688

Conserved Domains (4) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain