CLIP1 CAP-Gly domain containing linker protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CLIP1provided by HGNC
Official Full Name: CAP-Gly domain containing linker protein 1provided by HGNC
Primary source: HGNC:HGNC:10461
See related: Ensembl:ENSG00000130779 MIM:179838; AllianceGenome:HGNC:10461
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RSN; CLIP; CYLN1; CLIP170; CLIP-170
Summary: The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression: Ubiquitous expression in thyroid (RPKM 36.8), esophagus (RPKM 33.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.31

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (122271469..122422956, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (122267259..122418870, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (122756016..122907216, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CLIP170 inhibits the metastasis and EMT of papillary thyroid cancer through the TGF-beta pathway.
Title: CLIP170 inhibits the metastasis and EMT of papillary thyroid cancer through the TGF-β pathway.
Restin protein expression in non-small cell lung cancer.
Title: Restin protein expression in non-small cell lung cancer.
The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer.
Title: The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer.
CLIP-170S is a microtubule +TIP variant that confers resistance to taxanes by impairing drug-target engagement.
Title: CLIP-170S is a microtubule +TIP variant that confers resistance to taxanes by impairing drug-target engagement.
SOCS3-microtubule interaction via CLIP-170 and CLASP2 is critical for modulation of endothelial inflammation and lung injury.
Title: SOCS3-microtubule interaction via CLIP-170 and CLASP2 is critical for modulation of endothelial inflammation and lung injury.
Stress-induced phosphorylation of CLIP-170 by JNK promotes microtubule rescue.
Title: Stress-induced phosphorylation of CLIP-170 by JNK promotes microtubule rescue.
CLIP-170 spatially modulates recycling of the Met RTK through direct binding of CLIP-170 to GGA3.
Title: CLIP-170 spatially modulates receptor tyrosine kinase recycling to coordinate cell migration.
CLIP-170 plays an indispensable role in MTOC repositioning and full activation of T cells by regulating dynein localisation.
Title: CLIP-170 is essential for MTOC repositioning during T cell activation by regulating dynein localisation on the cell surface.
Long noncoding RNA ANRIL regulates endothelial cell activities associated with coronary artery disease by up-regulating CLIP1, EZR, and LYVE1 genes
Title: Long noncoding RNA ANRIL regulates endothelial cell activities associated with coronary artery disease by up-regulating CLIP1, EZR, and LYVE1 genes.
finding that CLIP-170 has multiple non-CAP-Gly EB1-binding modules may explain why autoinhibition of CLIP-170 GAP-Gly domains does not fully abrogate its microtubule plus-end localization. This work expands our understanding of EB1-binding motifs and their multivalent networks.
Title: Mapping multivalency in the CLIP-170-EB1 microtubule plus-end complex.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G64573 (e-PCR)
- UniSTS:163852

WI-14983 (e-PCR)
- UniSTS:29728

D12S1902 (e-PCR)
- UniSTS:21040

G59364 (e-PCR)
- UniSTS:136529

G29081 (e-PCR)
- UniSTS:46716

D12S1321 (e-PCR)
- UniSTS:71300

D12S1158E (e-PCR)
- UniSTS:151440

D12S1167E (e-PCR)
- UniSTS:151448

D12S1172E (e-PCR)
- UniSTS:151453

SHGC-83339 (e-PCR)
- UniSTS:101044

STS-X64838 (e-PCR)
- UniSTS:26054

RH45231 (e-PCR)
- UniSTS:83179

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule plus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule plus-end binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule bundle formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of microtubule polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intermediate filament	TAS Traceable Author Statement more info	PubMed
located_in kinetochore	TAS Traceable Author Statement more info	PubMed
colocalizes_with macropinosome	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
colocalizes_with microtubule plus-end	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in ruffle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CAP-Gly domain-containing linker protein 1

Names: cytoplasmic linker protein 1; cytoplasmic linker protein 170 alpha-2; cytoplasmic linker protein CLIP-170; restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030352.1 RefSeqGene

Range

4901..156101

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001247997.2 → NP_001234926.1 CAP-Gly domain-containing linker protein 1 isoform c

See identical proteins and their annotated locations for NP_001234926.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).

Source sequence(s)

AC048338, AC127002, BC126305, CB305431, M97501

Consensus CDS

CCDS58285.1

UniProtKB/Swiss-Prot

A0AVD3, P30622, Q17RS4, Q29RG0

UniProtKB/TrEMBL

J3KP58

Related

ENSP00000479322.1, ENST00000620786.5

Conserved Domains (5) summary

COG5244
Location:212 → 812

NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]

pfam01302
Location:215 → 278

CAP_GLY; CAP-Gly domain

pfam07851
Location:567 → 666

TMPIT; TMPIT-like protein

pfam10174
Location:474 → 1255

Cast; RIM-binding protein of the cytomatrix active zone

pfam16641
Location:1416 → 1432

CLIP1_ZNF; CLIP1 zinc knuckle
NM_001389291.1 → NP_001376220.1 CAP-Gly domain-containing linker protein 1 isoform d

Status: REVIEWED

Source sequence(s)

AC048338, AC079406, AC127002

Conserved Domains (4) summary

COG0419
Location:335 → 835

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:612 → 1442

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam01302
Location:214 → 278

CAP_GLY; CAP-Gly domain

pfam16641
Location:2126 → 2142

CLIP1_ZNF; CLIP1 zinc knuckle
NM_002956.3 → NP_002947.1 CAP-Gly domain-containing linker protein 1 isoform a

See identical proteins and their annotated locations for NP_002947.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c.

Source sequence(s)

AC127002, AK126990, M97501, X64838

Consensus CDS

CCDS9232.1

UniProtKB/TrEMBL

J3KP58

Related

ENSP00000351665.2, ENST00000358808.6

Conserved Domains (4) summary

TIGR04523
Location:429 → 1147

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam01302
Location:215 → 278

CAP_GLY; CAP-Gly domain

pfam07851
Location:556 → 655

TMPIT; TMPIT-like protein

pfam16641
Location:1405 → 1421

CLIP1_ZNF; CLIP1 zinc knuckle
NM_198240.3 → NP_937883.1 CAP-Gly domain-containing linker protein 1 isoform b

See identical proteins and their annotated locations for NP_937883.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two consecutive alternate in-frame exons compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform c.

Source sequence(s)

AC127002, AK126990, BM998166, M97501, X64838

Consensus CDS

CCDS9233.1

UniProtKB/TrEMBL

J3KP58

Related

ENSP00000445531.1, ENST00000537178.5

Conserved Domains (5) summary

COG1196
Location:609 → 1250

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5244
Location:212 → 866

NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]

pfam01302
Location:215 → 278

CAP_GLY; CAP-Gly domain

pfam07851
Location:521 → 620

TMPIT; TMPIT-like protein

pfam16641
Location:1370 → 1386

CLIP1_ZNF; CLIP1 zinc knuckle

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

122271469..122422956 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047429314.1 → XP_047285270.1 CAP-Gly domain-containing linker protein 1 isoform X6

UniProtKB/TrEMBL

J3KP58
XM_047429321.1 → XP_047285277.1 CAP-Gly domain-containing linker protein 1 isoform X13

UniProtKB/TrEMBL

J3KP58
XM_047429320.1 → XP_047285276.1 CAP-Gly domain-containing linker protein 1 isoform X12

UniProtKB/TrEMBL

J3KP58
XM_047429318.1 → XP_047285274.1 CAP-Gly domain-containing linker protein 1 isoform X9

UniProtKB/TrEMBL

J3KP58

Related

ENSP00000641630.1, ENST00000971571.1
XM_047429319.1 → XP_047285275.1 CAP-Gly domain-containing linker protein 1 isoform X11

UniProtKB/TrEMBL

J3KP58

Related

ENSP00000529949.1, ENST00000859890.1
XM_017019792.3 → XP_016875281.1 CAP-Gly domain-containing linker protein 1 isoform X10

UniProtKB/TrEMBL

J3KP58
XM_017019788.3 → XP_016875277.1 CAP-Gly domain-containing linker protein 1 isoform X6

UniProtKB/TrEMBL

J3KP58
XM_017019791.3 → XP_016875280.1 CAP-Gly domain-containing linker protein 1 isoform X8

UniProtKB/TrEMBL

J3KP58
XM_006719552.5 → XP_006719615.1 CAP-Gly domain-containing linker protein 1 isoform X2

UniProtKB/TrEMBL

J3KP58

Conserved Domains (4) summary

TIGR04523
Location:429 → 1147

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam01302
Location:215 → 278

CAP_GLY; CAP-Gly domain

pfam07851
Location:556 → 655

TMPIT; TMPIT-like protein

pfam16641
Location:1407 → 1423

CLIP1_ZNF; CLIP1 zinc knuckle
XM_047429313.1 → XP_047285269.1 CAP-Gly domain-containing linker protein 1 isoform X5

UniProtKB/TrEMBL

J3KP58

Related

ENSP00000529947.1, ENST00000859888.1
XM_047429312.1 → XP_047285268.1 CAP-Gly domain-containing linker protein 1 isoform X4

UniProtKB/TrEMBL

J3KP58
XM_005253593.4 → XP_005253650.1 CAP-Gly domain-containing linker protein 1 isoform X1

UniProtKB/TrEMBL

J3KP58

Conserved Domains (5) summary

COG5244
Location:212 → 812

NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]

pfam01302
Location:215 → 278

CAP_GLY; CAP-Gly domain

pfam07851
Location:567 → 666

TMPIT; TMPIT-like protein

pfam10174
Location:474 → 1255

Cast; RIM-binding protein of the cytomatrix active zone

pfam16641
Location:1418 → 1434

CLIP1_ZNF; CLIP1 zinc knuckle
XM_047429317.1 → XP_047285273.1 CAP-Gly domain-containing linker protein 1 isoform X7

UniProtKB/TrEMBL

J3KP58
XM_047429315.1 → XP_047285271.1 CAP-Gly domain-containing linker protein 1 isoform X6

UniProtKB/TrEMBL

J3KP58
XM_047429311.1 → XP_047285267.1 CAP-Gly domain-containing linker protein 1 isoform X4

UniProtKB/TrEMBL

J3KP58
XM_047429307.1 → XP_047285263.1 CAP-Gly domain-containing linker protein 1 isoform X1

UniProtKB/TrEMBL

J3KP58
XM_047429316.1 → XP_047285272.1 CAP-Gly domain-containing linker protein 1 isoform X7

UniProtKB/TrEMBL

J3KP58
XM_017019789.2 → XP_016875278.1 CAP-Gly domain-containing linker protein 1 isoform X6

UniProtKB/TrEMBL

J3KP58
XM_047429310.1 → XP_047285266.1 CAP-Gly domain-containing linker protein 1 isoform X3

UniProtKB/TrEMBL

J3KP58
XM_047429309.1 → XP_047285265.1 CAP-Gly domain-containing linker protein 1 isoform X2

UniProtKB/TrEMBL

J3KP58

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

122267259..122418870 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054372847.1 → XP_054228822.1 CAP-Gly domain-containing linker protein 1 isoform X6

UniProtKB/TrEMBL

J3KP58
XM_054372856.1 → XP_054228831.1 CAP-Gly domain-containing linker protein 1 isoform X13

UniProtKB/TrEMBL

J3KP58
XM_054372855.1 → XP_054228830.1 CAP-Gly domain-containing linker protein 1 isoform X12

UniProtKB/TrEMBL

J3KP58
XM_054372852.1 → XP_054228827.1 CAP-Gly domain-containing linker protein 1 isoform X9

UniProtKB/TrEMBL

J3KP58
XM_054372854.1 → XP_054228829.1 CAP-Gly domain-containing linker protein 1 isoform X11

UniProtKB/TrEMBL

J3KP58
XM_054372853.1 → XP_054228828.1 CAP-Gly domain-containing linker protein 1 isoform X10

UniProtKB/TrEMBL

J3KP58
XM_054372845.1 → XP_054228820.1 CAP-Gly domain-containing linker protein 1 isoform X6

UniProtKB/TrEMBL

J3KP58
XM_054372851.1 → XP_054228826.1 CAP-Gly domain-containing linker protein 1 isoform X8

UniProtKB/TrEMBL

J3KP58
XM_054372839.1 → XP_054228814.1 CAP-Gly domain-containing linker protein 1 isoform X2

UniProtKB/TrEMBL

J3KP58
XM_054372844.1 → XP_054228819.1 CAP-Gly domain-containing linker protein 1 isoform X5

UniProtKB/TrEMBL

J3KP58
XM_054372843.1 → XP_054228818.1 CAP-Gly domain-containing linker protein 1 isoform X4

UniProtKB/TrEMBL

J3KP58
XM_054372837.1 → XP_054228812.1 CAP-Gly domain-containing linker protein 1 isoform X1

UniProtKB/TrEMBL

J3KP58
XM_054372838.1 → XP_054228813.1 CAP-Gly domain-containing linker protein 1 isoform X1

UniProtKB/TrEMBL

J3KP58
XM_054372840.1 → XP_054228815.1 CAP-Gly domain-containing linker protein 1 isoform X2

UniProtKB/TrEMBL

J3KP58
XM_054372842.1 → XP_054228817.1 CAP-Gly domain-containing linker protein 1 isoform X4

UniProtKB/TrEMBL

J3KP58
XM_054372841.1 → XP_054228816.1 CAP-Gly domain-containing linker protein 1 isoform X3

UniProtKB/TrEMBL

J3KP58
XM_054372848.1 → XP_054228823.1 CAP-Gly domain-containing linker protein 1 isoform X6

UniProtKB/TrEMBL

J3KP58
XM_054372846.1 → XP_054228821.1 CAP-Gly domain-containing linker protein 1 isoform X6

UniProtKB/TrEMBL

J3KP58
XM_054372850.1 → XP_054228825.1 CAP-Gly domain-containing linker protein 1 isoform X7

UniProtKB/TrEMBL

J3KP58
XM_054372849.1 → XP_054228824.1 CAP-Gly domain-containing linker protein 1 isoform X7

UniProtKB/TrEMBL

J3KP58