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    BDKRB1 bradykinin receptor B1 [ Homo sapiens (human) ]

    Gene ID: 623, updated on 17-Jun-2024

    Summary

    Official Symbol
    BDKRB1provided by HGNC
    Official Full Name
    bradykinin receptor B1provided by HGNC
    Primary source
    HGNC:HGNC:1029
    See related
    Ensembl:ENSG00000100739 MIM:600337; AllianceGenome:HGNC:1029
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B1R; BKR1; B1BKR; BKB1R; BRADYB1
    Summary
    Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. [provided by RefSeq, Aug 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Biased expression in gall bladder (RPKM 7.4), urinary bladder (RPKM 5.2) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BDKRB1 in Genome Data Viewer
    Location:
    14q32.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (96256210..96264763)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (90487459..90496013)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96722547..96731100)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96563297-96563798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96642023-96642523 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96658061-96658668 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96659886-96660494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96660495-96661102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96661103-96661710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96661711-96662318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96664109-96664715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96670637-96671512 Neighboring gene bradykinin receptor B2 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:96697669-96697864 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96719533-96720042 Neighboring gene uncharacterized LOC124903375 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:96734992-96736191 Neighboring gene NANOG hESC enhancer GRCh37_chr14:96748657-96749197 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_38870 Neighboring gene autophagy related 2B Neighboring gene uncharacterized LOC124903430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8985 Neighboring gene Sharpr-MPRA regulatory region 11883 Neighboring gene GSK3B interacting protein Neighboring gene RNA, U2 small nuclear 33, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: BDKRB2

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables bradykinin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables bradykinin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    B1 bradykinin receptor
    Names
    BK-1 receptor
    bradykinin B1 receptor
    bradykinin receptor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000710.4NP_000701.2  B1 bradykinin receptor

      See identical proteins and their annotated locations for NP_000701.2

      Status: REVIEWED

      Source sequence(s)
      AJ238044, AL355102, CB130642
      Consensus CDS
      CCDS9943.1
      UniProtKB/Swiss-Prot
      A8K7F5, P46663, Q546S7, Q8N0Y8
      UniProtKB/TrEMBL
      A0A075E6Y0
      Related
      ENSP00000216629.6, ENST00000216629.11
      Conserved Domains (1) summary
      cd15380
      Location:38323
      7tmA_BK-1; bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001386007.1NP_001372936.1  B1 bradykinin receptor

      Status: REVIEWED

      Source sequence(s)
      AL355102
      Consensus CDS
      CCDS9943.1
      UniProtKB/Swiss-Prot
      A8K7F5, P46663, Q546S7, Q8N0Y8
      UniProtKB/TrEMBL
      A0A075E6Y0
      Related
      ENSP00000479276.1, ENST00000611804.1
      Conserved Domains (1) summary
      cd15380
      Location:38323
      7tmA_BK-1; bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      96256210..96264763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      90487459..90496013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)