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    RPS6KA1 ribosomal protein S6 kinase A1 [ Homo sapiens (human) ]

    Gene ID: 6195, updated on 5-Sep-2021

    Summary

    Official Symbol
    RPS6KA1provided by HGNC
    Official Full Name
    ribosomal protein S6 kinase A1provided by HGNC
    Primary source
    HGNC:HGNC:10430
    See related
    Ensembl:ENSG00000117676 MIM:601684
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RSK; HU-1; RSK1; p90Rsk; MAPKAPK1; MAPKAPK1A
    Summary
    This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in small intestine (RPKM 31.6), duodenum (RPKM 29.3) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RPS6KA1 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (26529761..26575028)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26856252..26901516)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr1.3789 Neighboring gene developmental pluripotency associated 2 pseudogene 2 Neighboring gene microRNA 1976 Neighboring gene RNA, 7SL, cytoplasmic 679, pseudogene Neighboring gene uncharacterized LOC105376888

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables protein serine/threonine/tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemical synaptic transmission TAS
    Traceable Author Statement
    more info
     
    involved_in hepatocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cell growth TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of hepatic stellate cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription in response to stress TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of translation in response to stress TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ribosomal protein S6 kinase alpha-1
    Names
    90 kDa ribosomal protein S6 kinase 1
    MAP kinase-activated protein kinase 1a
    MAPK-activated protein kinase 1a
    MAPKAP kinase 1a
    MAPKAPK-1a
    RSK-1
    S6K-alpha 1
    dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)
    p90-RSK 1
    p90RSK1
    p90S6K
    ribosomal S6 kinase 1
    ribosomal protein S6 kinase, 90kDa, polypeptide 1
    NP_001006666.1
    NP_001317370.1
    NP_002944.2
    XP_024304639.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006665.2NP_001006666.1  ribosomal protein S6 kinase alpha-1 isoform b

      See identical proteins and their annotated locations for NP_001006666.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' end of the coding region compared to variant 1. These differences cause translation initiation at an in-frame AUG of an alternate exon and an isoform (b) with a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL627313
      Consensus CDS
      CCDS30649.1
      UniProtKB/Swiss-Prot
      Q15418
      Related
      ENSP00000435412.1, ENST00000531382.5
      Conserved Domains (4) summary
      smart00220
      Location:71329
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:75391
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14175
      Location:425715
      STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
      pfam00069
      Location:427684
      Pkinase; Protein kinase domain
    2. NM_001330441.2NP_001317370.1  ribosomal protein S6 kinase alpha-1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' end of the coding region compared to variant 1. These differences cause translation initiation at an in-frame AUG of an alternate exon and an isoform (c) with a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL627313
      Consensus CDS
      CCDS81286.1
      UniProtKB/Swiss-Prot
      Q15418
      Related
      ENSP00000432281.1, ENST00000530003.5
      Conserved Domains (2) summary
      cd05582
      Location:50366
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14175
      Location:400690
      STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
    3. NM_002953.4NP_002944.2  ribosomal protein S6 kinase alpha-1 isoform a

      See identical proteins and their annotated locations for NP_002944.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
      Source sequence(s)
      AL627313
      Consensus CDS
      CCDS284.1
      UniProtKB/Swiss-Prot
      Q15418
      Related
      ENSP00000363283.2, ENST00000374168.7
      Conserved Domains (2) summary
      cd05582
      Location:66382
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14175
      Location:416706
      STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      26529761..26575028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448871.1XP_024304639.1  ribosomal protein S6 kinase alpha-1 isoform X1

      Related
      ENSP00000431651.1, ENST00000526792.5
      Conserved Domains (2) summary
      cd05582
      Location:1290
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14175
      Location:324614
      STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)

    Reference GRCh38.p13 PATCHES

    Genomic

    1. NW_009646195.1 Reference GRCh38.p13 PATCHES

      Range
      17379..62643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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