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    RPL22 ribosomal protein L22 [ Homo sapiens (human) ]

    Gene ID: 6146, updated on 4-Nov-2018

    Summary

    Official Symbol
    RPL22provided by HGNC
    Official Full Name
    ribosomal protein L22provided by HGNC
    Primary source
    HGNC:HGNC:10315
    See related
    Ensembl:ENSG00000116251 MIM:180474; Vega:OTTHUMG00000000953
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EAP; L22; HBP15; HBP15/L22
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 336.6), endometrium (RPKM 190.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See RPL22 in Genome Data Viewer
    Location:
    1p36.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (6185020..6199619, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6245080..6259679, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene protein GVQW2-like Neighboring gene chromodomain helicase DNA binding protein 5 Neighboring gene uncharacterized LOC105376687 Neighboring gene uncharacterized LOC107985733 Neighboring gene uncharacterized LOC102724450 Neighboring gene ring finger protein 207 Neighboring gene isoprenylcysteine carboxyl methyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
      Cap-dependent Translation Initiation, organism-specific biosystemTranslation initiation is a complex process in which the Met-tRNAi initiator, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the start c...
    • Cytoplasmic Ribosomal Proteins, organism-specific biosystem (from WikiPathways)
      Cytoplasmic Ribosomal Proteins, organism-specific biosystemThe contents of this pathway represents the ribosomal proteins involved in translation.
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Eukaryotic Translation Elongation, organism-specific biosystem (from REACTOME)
      Eukaryotic Translation Elongation, organism-specific biosystemThe translation elongation cycle adds one amino acid at a time to a growing polypeptide according to the sequence of codons found in the mRNA. The next available codon on the mRNA is exposed in the a...
    • Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
      Eukaryotic Translation Initiation, organism-specific biosystemInitiation of translation in the majority of eukaryotic cellular mRNAs depends on the 5'-cap (m7GpppN) and involves ribosomal scanning of the 5' untranslated region (5'-UTR) for an initiating AUG sta...
    • Eukaryotic Translation Termination, organism-specific biosystem (from REACTOME)
      Eukaryotic Translation Termination, organism-specific biosystemThe arrival of any of the three stop codons (UAA, UAG and UGA) into the ribosomal A-site triggers the binding of a release factor (RF) to the ribosome and subsequent polypeptide chain release. In euk...
    • Formation of a pool of free 40S subunits, organism-specific biosystem (from REACTOME)
      Formation of a pool of free 40S subunits, organism-specific biosystemThe 80S ribosome dissociates into free 40S (small) and 60S (large) ribosomal subunits. Each ribosomal subunit is constituted by several individual ribosomal proteins and rRNA.
    • GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem (from REACTOME)
      GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystemHydrolysis of eIF2-GTP occurs after the Met-tRNAi has recognized the AUG. This reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow ...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Infectious disease, organism-specific biosystem (from REACTOME)
      Infectious disease, organism-specific biosystem
      Infectious disease
    • Influenza Infection, organism-specific biosystem (from REACTOME)
      Influenza Infection, organism-specific biosystemFor centuries influenza epidemics have plagued man, and influenza was probably the disease described by Hippocrates in 412 BC. Today it remains a major cause of morbidity and mortality worldwide with...
    • Influenza Life Cycle, organism-specific biosystem (from REACTOME)
      Influenza Life Cycle, organism-specific biosystemThe virus particle initially associates with a human host cell by binding to sialic acid-containing receptors on the host cell surface. The bound virus is endocytosed by one of four distinct mechanis...
    • Influenza Viral RNA Transcription and Replication, organism-specific biosystem (from REACTOME)
      Influenza Viral RNA Transcription and Replication, organism-specific biosystemIn the host cell nucleus, the viral negative-strand RNA (vRNA) serves as a template for the synthesis both of capped, polyadenylated viral messenger RNA and of full-length positive-strand RNA or comp...
    • L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
      L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemWhile circularization of mRNA during translation initiation is thought to contribute to an increase in the efficiency of translation, it also appears to provide a mechanism for translational silencin...
    • Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystem (from REACTOME)
      Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystemIn humans, a 47S precursor rRNA (pre-rRNA) is transcribed by RNA polymerase I from rRNA-encoding genes (rDNA) at the boundary of the fibrillar center and the dense fibrillar components of the nucleol...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
      Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
      Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystemDuring normal translation termination eRF3 associates with the ribosome and then interacts with PABP bound to the polyadenylate tail of the mRNA to release the ribosome and allow a new round of trans...
    • Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
      Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), organism-specific biosystemNonsense-mediated decay has been observed with mRNAs that do not have an exon junction complex (EJC) downstream of the termination codon (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-An...
    • Nonsense-Mediated Decay (NMD), organism-specific biosystem (from REACTOME)
      Nonsense-Mediated Decay (NMD), organism-specific biosystemThe Nonsense-Mediated Decay (NMD) pathway activates the destruction of mRNAs containing premature termination codons (PTCs) (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-Ansmant et al. ...
    • Peptide chain elongation, organism-specific biosystem (from REACTOME)
      Peptide chain elongation, organism-specific biosystemThe mechanism of a peptide bond requires the movement of three protons. First the deprotonation of the ammonium ion generates a reactive amine, allowing a nucleophilic attack on the carbonyl group. ...
    • Ribosome, organism-specific biosystem (from KEGG)
      Ribosome, organism-specific biosystem
      Ribosome
    • Ribosome, conserved biosystem (from KEGG)
      Ribosome, conserved biosystem
      Ribosome
    • Ribosome, eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome, eukaryotes, organism-specific biosystemStructural complex; Genetic information processing; Ribosome
    • Ribosome, eukaryotes, conserved biosystem (from KEGG)
      Ribosome, eukaryotes, conserved biosystemStructural complex; Genetic information processing; Ribosome
    • SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystem (from REACTOME)
      SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystemThe process for translation of a protein destined for the endoplasmic reticulum (ER) branches from the canonical cytoslic translation process at the point when a nascent polypeptide containing a hydr...
    • Selenoamino acid metabolism, organism-specific biosystem (from REACTOME)
      Selenoamino acid metabolism, organism-specific biosystemSelenium (Se) is a trace element essential for the normal function of the body. Selenoamino acids are defined as those amino acids where selenium has been substituted for sulphur. Selenium and sulp...
    • Selenocysteine synthesis, organism-specific biosystem (from REACTOME)
      Selenocysteine synthesis, organism-specific biosystemSelenocysteine, the 21st genetically encoded amino acid, is the major form of the antioxidant trace element selenium in the human body. In eukaryotes and archaea its synthesis proceeds through a phos...
    • Translation, organism-specific biosystem (from REACTOME)
      Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...
    • Viral mRNA Translation, organism-specific biosystem (from REACTOME)
      Viral mRNA Translation, organism-specific biosystemSpliced and unspliced viral mRNA in the cytoplasm are translated by host cell ribosomal translation machinery (reviewed in Kash, 2006). At least ten viral proteins are synthesized: HA, NA, PB1, PB2...
    • rRNA processing, organism-specific biosystem (from REACTOME)
      rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
    • rRNA processing in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
      rRNA processing in the nucleus and cytosol, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    SRP-dependent cotranslational protein targeting to membrane TAS
    Traceable Author Statement
    more info
     
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
    Traceable Author Statement
    more info
     
    translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    translational initiation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    cytosolic large ribosomal subunit HDA PubMed 
    cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    focal adhesion HDA PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    60S ribosomal protein L22
    Names
    EBER-associated protein
    Epstein-Barr virus small RNA-associated protein
    Epstein-Barr-encoded RNA-associated protein
    heparin-binding protein 15
    heparin-binding protein HBp15
    large ribosomal subunit protein eL22

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000983.3NP_000974.1  60S ribosomal protein L22

      See identical proteins and their annotated locations for NP_000974.1

      Status: REVIEWED

      Source sequence(s)
      AF113701, AK097075, BU927988, CA336134
      Consensus CDS
      CCDS58.1
      UniProtKB/Swiss-Prot
      P35268
      Related
      ENSP00000346088.3, OTTHUMP00000001141, ENST00000234875.8, OTTHUMT00000002830
      Conserved Domains (1) summary
      pfam01776
      Location:21119
      Ribosomal_L22e; Ribosomal L22e protein family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      6185020..6199619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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