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    GRK1 G protein-coupled receptor kinase 1 [ Homo sapiens (human) ]

    Gene ID: 6011, updated on 16-Oct-2021

    Summary

    Official Symbol
    GRK1provided by HGNC
    Official Full Name
    G protein-coupled receptor kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:10013
    See related
    Ensembl:ENSG00000185974 MIM:180381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RK; RHOK; GPRK1
    Summary
    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]
    Annotation information
    Note: This gene aligns across a gap in the GRCh38 reference genome assembly, and therefore, the 5' end of this gene was annotated on NT_027140.7 and the 3' end was annotated on NT_024498.13 in NCBI s Homo sapiens Annotation Release 106. [17 Jun 2014]
    Annotation category: suggests misassembly
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See GRK1 in Genome Data Viewer
    Location:
    13q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (113645771..113737736)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114321534..114440709)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene defective in cullin neddylation 1 domain containing 2 Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene transcription factor Dp-1 Neighboring gene ATPase H+/K+ transporting subunit beta Neighboring gene basic salivary proline-rich protein 4-like Neighboring gene long intergenic non-protein coding RNA 552 Neighboring gene transmembrane protein 255B Neighboring gene GAS6 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables rhodopsin kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables rhodopsin kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables rhodopsin kinase activity TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in photoreceptor disc membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    rhodopsin kinase GRK1
    NP_002920.1
    XP_016876173.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002929.3NP_002920.1  rhodopsin kinase GRK1

      See identical proteins and their annotated locations for NP_002920.1

      Status: REVIEWED

      Source sequence(s)
      AC187648, BX537316
      Consensus CDS
      CCDS81785.1
      UniProtKB/Swiss-Prot
      Q15835
      Related
      ENSP00000334876.5, ENST00000335678.7
      Conserved Domains (2) summary
      cd05608
      Location:188475
      STKc_GRK1; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1
      cl02565
      Location:42179
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      113645771..113737736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020684.1XP_016876173.1  rhodopsin kinase GRK1 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1240
      PKc_like; Protein Kinases, catalytic domain

    Reference GRCh38.p13 PATCHES

    Genomic

    1. NW_021160011.1 Reference GRCh38.p13 PATCHES

      Range
      18042..39335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p13 ALT_REF_LOCI_1

    Genomic

    1. NT_187596.1 Reference GRCh38.p13 ALT_REF_LOCI_1

      Range
      4331..11261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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