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    RGS16 regulator of G protein signaling 16 [ Homo sapiens (human) ]

    Gene ID: 6004, updated on 27-Nov-2024

    Summary

    Official Symbol
    RGS16provided by HGNC
    Official Full Name
    regulator of G protein signaling 16provided by HGNC
    Primary source
    HGNC:HGNC:9997
    See related
    Ensembl:ENSG00000143333 MIM:602514; AllianceGenome:HGNC:9997
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RGS-R; A28-RGS14; A28-RGS14P
    Summary
    The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in thyroid (RPKM 20.2), lung (RPKM 3.6) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RGS16 in Genome Data Viewer
    Location:
    1q25.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (182598623..182604389, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (181958121..181963886, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (182567758..182573524, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:182419119-182419726 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:182443692-182444891 Neighboring gene regulator of G protein signaling like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2198 Neighboring gene ribonuclease L Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2203 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:182584000-182584897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:182584926-182585474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:182585475-182586022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2205 Neighboring gene long intergenic non-protein coding RNA 1686 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:182612621-182613820 Neighboring gene regulator of G protein signaling 8 Neighboring gene long intergenic non-protein coding RNA 1688

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
     
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    regulator of G-protein signaling 16
    Names
    hRGS-r
    regulator of G-protein signalling 16
    retinal-specific RGS
    retinally abundant regulator of G-protein signaling

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002928.4NP_002919.3  regulator of G-protein signaling 16

      See identical proteins and their annotated locations for NP_002919.3

      Status: REVIEWED

      Source sequence(s)
      AL353778, BC006243, DA060276, DC349953
      Consensus CDS
      CCDS1348.1
      UniProtKB/Swiss-Prot
      B2R4M4, O15492, Q5VYN9, Q99701
      Related
      ENSP00000356529.5, ENST00000367558.6
      Conserved Domains (1) summary
      cd08710
      Location:66179
      RGS_RGS16; Regulator of G protein signaling (RGS) domain found in the RGS16 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      182598623..182604389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448796.1XP_024304564.1  regulator of G-protein signaling 16 isoform X1

      Conserved Domains (1) summary
      cd08710
      Location:65178
      RGS_RGS16; Regulator of G protein signaling (RGS) domain found in the RGS16 protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      181958121..181963886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338046.1XP_054194021.1  regulator of G-protein signaling 16 isoform X1