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    RGS13 regulator of G protein signaling 13 [ Homo sapiens (human) ]

    Gene ID: 6003, updated on 8-Dec-2018

    Summary

    Official Symbol
    RGS13provided by HGNC
    Official Full Name
    regulator of G protein signaling 13provided by HGNC
    Primary source
    HGNC:HGNC:9995
    See related
    Ensembl:ENSG00000127074 MIM:607190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in lymph node (RPKM 52.7), appendix (RPKM 9.2) and 2 other tissues See more
    Orthologs

    Genomic context

    See RGS13 in Genome Data Viewer
    Location:
    1q31.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (192636138..192660311)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (192605268..192629441)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371664 Neighboring gene regulator of G protein signaling 1 Neighboring gene uncharacterized LOC107985241 Neighboring gene HNF1 motif-containing MPRA enhancer 26 Neighboring gene ribosomal protein S27a pseudogene 5 Neighboring gene microRNA 4426

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC17173

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    regulator of G-protein signaling 13
    Names
    regulator of G-protein signalling 13

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002927.4NP_002918.1  regulator of G-protein signaling 13

      See identical proteins and their annotated locations for NP_002918.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      BC056866, BU942880
      Consensus CDS
      CCDS1376.1
      UniProtKB/Swiss-Prot
      O14921
      UniProtKB/TrEMBL
      A0A024R989
      Related
      ENSP00000375853.2, ENST00000391995.6
      Conserved Domains (1) summary
      cd08716
      Location:35148
      RGS_RGS13; Regulator of G protein signaling (RGS) domain found in the RGS13 protein
    2. NM_144766.2NP_658912.1  regulator of G-protein signaling 13

      See identical proteins and their annotated locations for NP_658912.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      BC016667, BC056866, BU942880
      Consensus CDS
      CCDS1376.1
      UniProtKB/Swiss-Prot
      O14921
      UniProtKB/TrEMBL
      A0A024R989
      Related
      ENSP00000442837.1, ENST00000543215.5
      Conserved Domains (1) summary
      cd08716
      Location:35148
      RGS_RGS13; Regulator of G protein signaling (RGS) domain found in the RGS13 protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      192636138..192660311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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