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    RGS13 regulator of G protein signaling 13 [ Homo sapiens (human) ]

    Gene ID: 6003, updated on 5-Mar-2024

    Summary

    Official Symbol
    RGS13provided by HGNC
    Official Full Name
    regulator of G protein signaling 13provided by HGNC
    Primary source
    HGNC:HGNC:9995
    See related
    Ensembl:ENSG00000127074 MIM:607190; AllianceGenome:HGNC:9995
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in lymph node (RPKM 52.7), appendix (RPKM 9.2) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    1q31.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (192636147..192660311)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (191983284..192007378)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (192605277..192629441)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371664 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2263 Neighboring gene regulator of G protein signaling 1 Neighboring gene uncharacterized LOC107985241 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:192637387-192637888 Neighboring gene HNF1 motif-containing MPRA enhancer 26 Neighboring gene ribosomal protein S27a pseudogene 5 Neighboring gene microRNA 4426 Neighboring gene uncharacterized LOC105371665

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC17173

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    regulator of G-protein signaling 13
    Names
    regulator of G-protein signalling 13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002927.5NP_002918.1  regulator of G-protein signaling 13

      See identical proteins and their annotated locations for NP_002918.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AL136454, AL596119
      Consensus CDS
      CCDS1376.1
      UniProtKB/Swiss-Prot
      O14921, Q6PGR2, Q8TD63, Q9BX45
      Related
      ENSP00000375853.2, ENST00000391995.7
      Conserved Domains (1) summary
      cd08716
      Location:35148
      RGS_RGS13; Regulator of G protein signaling (RGS) domain found in the RGS13 protein
    2. NM_144766.3NP_658912.1  regulator of G-protein signaling 13

      See identical proteins and their annotated locations for NP_658912.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL136454, AL596119
      Consensus CDS
      CCDS1376.1
      UniProtKB/Swiss-Prot
      O14921, Q6PGR2, Q8TD63, Q9BX45
      Related
      ENSP00000442837.1, ENST00000543215.5
      Conserved Domains (1) summary
      cd08716
      Location:35148
      RGS_RGS13; Regulator of G protein signaling (RGS) domain found in the RGS13 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      192636147..192660311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      191983284..192007378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)